Recruiting

Financial Incentive

Sponsor:

University of Oklahoma

Code:

NCT07080788

Conditions

Smoking Cessation Intervention

Pain

Smoking (Tobacco) Addiction

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Smoking Cessation

Study Details

Brief summary:

The goal of this pilot study is to assess whether 4-weeks of verified smoking abstinence following financial incentive treatment for smoking cessation improves physiological markers of chronic pain risk in adult Native American smokers.

The main aims to answer are:

1. Determine study feasibility.
2. Obtain effect sizes for changes in pain amplification and pain inhibition in abstinent vs non-abstinent Native Americans.
3. Obtain effect sizes for variables in the conceptual model of the Native American smoking-pain relationship.

Conditions

Smoking Cessation Intervention

Pain

Smoking (Tobacco) Addiction

Study ID

NCT07080788

Start date

Sep 1, 2025

Status verified date

Feb, 2026

Completion date

Jun, 2028

Anticipated

Primary completion date

Jun, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Self-identify as Native American/American Indian
  • Currently daily smoker
  • Own a smartphone with a data plan
  • Ability to speak and read English

Exclusion Criteria:

  • >18 years of age
  • Currently pregnant
  • Self-reported history of heart disease or heart attack
  • Angina, arrhythmias, hypertension, heart disease
  • Current chronic pain
  • Pepper allergy
  • Inability to speak English
  • Current psychosis (assessed by Psychosis Screening Questionnaire)
  • Serious cognitive impairment (assessed by <20 score on the Montreal Cognitive Assessment \[MoCA\])

Study Design

Enrollment

150 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Smoking Cessation

Interventions

Smoking Cessation

Investigators will provide financial incentives for biochemically verified abstinence at 4 weeks following treatment. This incentive is consistent with recent research using macro-level financial incentives and incorporates both short-term and long-term incentives to shape behavior.

Primary outcome measure

  • Pain inhibition [ Time Frame: Baseline (1 day prior to smoking cessation treatment allocation) and Post-Treatment (following 4 weeks of treatment + 4 weeks of verified smoking abstinence) ]
  • Inhibition of pain-related spinal reflex [ Time Frame: Baseline (1 day prior to smoking cessation treatment allocation) and Post-Treatment (following 4 weeks of treatment + 4 weeks of verified smoking abstinence) ]
  • Allostatic load [ Time Frame: Baseline (1 day prior to smoking cessation treatment allocation) and Post-Treatment (following 4 weeks of treatment + 4 weeks of verified smoking abstinence) ]
  • Pain amplification [ Time Frame: Baseline (1 day prior to smoking cessation treatment allocation) and Post-Treatment (following 4 weeks of treatment + 4 weeks of verified smoking abstinence) ]

Central Contacts and Locations

Central contacts

PLAN Lab

918-660-3048tulsa.plan@gmail.com

Jamie L Rhudy, PhD

918-660-3050jamie-rhudy@ouhsc.edu

Locations

University of Oklahoma - Schusterman Center

Recruiting

Tulsa, Oklahoma, United States, 74135

Contacts

PLAN Lab

918-660-3048oksnap4cessation@gmail.com

Jamie L Rhudy, PhD

918-660-3050jamie-rhudy@ouhsc.edu

Principal Investigator:

Jamie L Rhudy, PhD

More Information

Sponsor

University of Oklahoma

Last update posted

Mar 2, 2026

Last verified

Feb, 2026

Keywords

  • Smoking cessation
  • Quantitative sensory testing

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-11. This information was provided to ClinicalTrials.gov by University of Oklahoma on 2026-03-02.