Recruiting

N1 Dental Implants

Sponsor:

Louisiana State University Health Sciences Center in New Orleans

Code:

NCT07280260

Conditions

Tooth Loss

Dental Implant

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Nobel N1 implant

Study Details

Brief summary:

The purpose of the study is to evaluate whether N1 dental implants are successful when a final crown is placed on them at 6 weeks from implant placement surgery.

Conditions

Tooth Loss

Dental Implant

Study ID

NCT07280260

Start date

Dec 15, 2025

Status verified date

Aug, 2026

Completion date

Jan 30, 2028

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Males and females, age 18 or older

  • Can provide an Informed Consent in English.
  • Absence of a single posterior tooth in mandible or maxilla with presence of natural neighboring teeth (except for second molar which only requires presence of first molar)
  • Presence of antagonist teeth
  • Possibility and will for an immediate restoration.
  • Systemic health recorded as an American Society of Anesthesiologists (ASA) I or II

Exclusion Criteria:

  • · Unavailability to attend the follow-up visits.

  • A systemic contraindication for oral surgical procedures; ASA III or IV.
  • Pregnancy or nursing on screening or before the surgical procedure.
  • Diseases that could alter healing or bone metabolism (uncontrolled diabetes, diagnostic osteoporosis, etc.),
  • Taking medications that are altering healing or bone metabolism (bisphosphonates, long-time corticosteroids intake, RANK inhibitors, etc.)
  • Alcohol or drug abuse.
  • Current heavy smoking behavior (≥10 cigarettes/day).
  • Radiation therapy to the head or neck region.
  • Pathology in the implant planned sites that prevent implant placement.
  • Current diagnosis of Diabetes, which is uncontrolled (>7 HbA1C).
  • Need for sinus lift or vertical bone augmentation
  • Previously failed implant site

Study Design

Enrollment

50 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Early loading

Delivery of the final crowns 6 weeks after the implant placement.

other: Delayed loading

Delivery of the final crowns 12 weeks after the implant placement.

Interventions

Nobel N1 implant

A Nobel N1 implant will be placed and restored with a On 1 base

Primary outcome measure

  • Implant survival [ Time Frame: 6 months, 1 year ]
  • Misch implant success criteria [ Time Frame: 6 months, 1 year ]

Central Contacts and Locations

Central contacts

Amir Nejat

504-981-8283anejat@lsuhsc.edu

Jeanne St Germain

504-941-8276jstge1@lsuhsc.edu

Locations

LSU School of Dentistry

Recruiting

New Orleans, Louisiana, United States, 70119

Contacts

Amir Nejat

504-981-8283anejat@lsuhsc.edu

Jeanne St Germain

504-941-8276jstge1@lsuhsc.edu

More Information

Sponsor

Louisiana State University Health Sciences Center in New Orleans

Last update posted

Aug 27, 2026

Last verified

Aug, 2026

Keywords

  • Tooth loss
  • Edentulous
  • Dental implants

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Louisiana State University Health Sciences Center in New Orleans on 2026-08-27.