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ALS Clinical Trials

Browse 127 ALS clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

for
Moderately to Severely Active Ulcerative Colitis
Location: Providence RI, Lebanon NH, North Massapequa NY,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 16 - 70+

Code: NCT06588855

Phase3, Recruiting
Active & Responsive

Multicenter ALS Imaging Study

for
Amyotrophic Lateral Sclerosis, ALS
Location: Gainesville FL, Evanston IL, Minneapolis MN
Sponsor: University of Minnesota

Sex: All

Age: 18+

Code: NCT06735014

Recruiting
Active & Responsive

Healing ALS Registry Observational Study (HAROS)

for
Amyotrophic Lateral Sclerosis (ALS), Motor Neuron Disease (MND),
Location: Park City UT
Sponsor: Healing Advocates Registry and Ministry

Sex: All

Age: 18 - 70+

Code: NCT07233148

Recruiting
Active & Responsive

Retinal Imaging in Neurodegenerative Disease

for
Alzheimer's Disease, Mild Cognitive Impairment,
Location: Durham NC
Sponsor: Duke University

Sex: All

Age: 18+

Code: NCT03233646

Recruiting
Active & ResponsiveNew

Biofluid Research on Age-Related or Inherited Neurodegeneration

for
Frontotemporal Degeneration (FTD),
Location: Philadelphia PA
Sponsor: University of Pennsylvania

Sex: All

Age: 18+

Code: NCT07798700

Recruiting

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ALS/MND Natural History Study Data Repository

for
ALS, PLS, MND (Motor Neurone DIsease), Kennedy Disease,
Location: Burlington MA, Philadelphia PA, Richmond VA,
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18 - 70+

Code: NCT05966038

Recruiting
Active & Responsive

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for
Frontotemporal Lobar Degeneration (FTLD),
Location: Boston MA, New York NY, Philadelphia PA, Baltimore MD,
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT04363684

Recruiting
Active & Responsive

Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)

for
Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS),
Location: Baltimore MD
Sponsor: Johns Hopkins University

Sex: All

Age: 18 - 70+

Code: NCT07521930

Recruiting
Active & Responsive

PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS

for
Amyotrophic Lateral Sclerosis (ALS)
Location: New York NY, Jacksonville FL, Scottsdale AZ,
Sponsor: PhenoNet, Inc.

Sex: All

Age: 18 - 70+

Code: NCT07142291

Phase2, Recruiting
Active & Responsive

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

for
Amyotrophic Lateral Sclerosis
Location: Boston MA, New York NY, Montreal, Philadelphia PA,
Sponsor: Prilenia

Sex: All

Age: 18 - 70+

Code: NCT07322003

Phase3, Recruiting
Active & Responsive

Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

for
Amyotrophic Lateral Sclerosis, Movement Disorders,
Location: Boston MA, New York NY, Georgetown DC, Jacksonville FL,
Sponsor: Target ALS Foundation, Inc.

Sex: All

Age: 18+

Code: NCT05137665

Recruiting
Active & Responsive

FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases

for
Alpha-Thalassemia, Beta-Thalassemia, Amyloidosis,
Location: Los Altos CA
Sponsor: xCures

Sex: All

Age: 0+

Code: NCT06539169

Recruiting
Active & Responsive

ASSESS ALL ALS Study

for
Amyotrophic Lateral Sclerosis
Location: Boston MA, New Britain CT, Lebanon NH, New York NY,
Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All

Age: 18+

Code: NCT06578195

Recruiting
Active & Responsive

Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Amisodin in Healthy Adult Subjects With Amyotrophic Lateral Sclerosis

for
Amyotrophic Lateral Sclerosis
Location: Baltimore MD
Sponsor: PRG Science & Technology Co., Ltd.

Sex: All

Age: 18 - 55

Code: NCT07221240

Phase1, Recruiting
Active & Responsive

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

for
Rare Disorders, Undiagnosed Disorders,
Location: Sioux Falls SD
Sponsor: Sanford Health

Sex: All

Age: 0+

Code: NCT01793168

Recruiting
Active & Responsive

A Study to Evaluate the Performance of a Diagnostic Test in ALS

for
Amyotrophic Lateral Sclerosis (ALS)
Location: Cleveland OH
Sponsor: Iron Horse Diagnostics, Inc.

Sex: All

Age: 21 - 70+

Code: NCT02759913

Recruiting
Active & Responsive

Intermuscular Coherence as a Biomarker for ALS

for
Amyotrophic Lateral Sclerosis
Location: Boston MA, Miami FL, St Louis MO
Sponsor: University of Chicago

Sex: All

Age: 20 - 70+

Code: NCT05104710

Recruiting
Active & Responsive

Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth

for
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Location: Salisbury MD
Sponsor: TidalHealth, Inc.

Sex: All

Age: 18+

Code: NCT07491484

Recruiting
Active & Responsive

A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)

for
Amyotrophic Lateral Sclerosis
Location: Worcester MA, Philadelphia PA, Baltimore MD,
Sponsor: Insmed Gene Therapy LLC

Sex: All

Age: 18 - 70+

Code: NCT07290062

Phase1, Recruiting
Active & Responsive

Zanubrutinib and Lisocabtagene Maraleucel for the Treatment of Richter's Syndrome

for
Recurrent Transformed Chronic Lymphocytic Leukemia,
Location: New York NY, Columbus OH, Salt Lake City UT
Sponsor: Aseel Alsouqi

Sex: All

Age: 18+

Code: NCT05873712

Phase2, Recruiting

What are ALS clinical trials?

Amyotrophic Lateral Sclerosis (ALS) clinical trials are research studies conducted to explore and evaluate new treatments, therapies, and diagnostic tools for ALS, commonly known as Lou Gehrig’s disease. These trials are crucial in the search for effective ways to slow the progression of the disease, manage symptoms, and ultimately find a cure for ALS.

The importance of clinical trials in ALS research

Clinical trials are essential in ALS research as they are the primary method for testing new treatments and interventions. They help in understanding the effectiveness and safety of these treatments in humans. Through these trials, researchers can uncover new insights into the disease, leading to improved care, symptom management, and potentially life-extending therapies for those affected by ALS.

Types of ALS clinical trials

Innovations in ALS treatment through clinical trials

Who can participate in ALS clinical trials?

How to enroll in an ALS clinical trial