Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)
Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
Study of QUAIL-100 in Pediatric and Young Adult Participants With High-Risk Hematologic Malignancies Who Have Received a Hematopoietic Stem Cell Transplantation
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CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
A Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation (ALLOHA)
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
What stem cell therapy clinical trials are studying now
Transplants for blood cancers and blood disorders. Hematopoietic stem cell transplant replaces a person's blood forming system with their own stored cells or a donor's. Trials test safer conditioning, better donor matching, including half matched family donors for sickle cell disease, and ways to prevent graft versus host disease.
Transplants for autoimmune disease. Resetting the immune system with a person's own stem cells is being tested against the best available drugs in relapsing multiple sclerosis, in a Phase 3 trial funded by the National Institutes of Health at more than 20 US sites.
Mesenchymal stromal cells. Cells from bone marrow or fat that calm inflammation, tested for Crohn's disease, graft versus host disease, and hard to heal wounds. The first one was approved in 2024 after decades of trials.
Cells made from stem cells. Lab grown dopamine neurons for Parkinson's disease and insulin producing islet cells for type 1 diabetes, both now in or entering late stage trials.
Gene corrected stem cells. A person's own blood stem cells are edited to fix a mutation and returned. Two such therapies for sickle cell disease were approved in 2023; see gene therapy clinical trials. Immune cell therapies such as CAR T are a different technology, covered on our CAR T cell therapy page.
Stem cell transplants are part of care for leukemia, lymphoma, and multiple myeloma; each page lists its own studies.
New to research? Read how informed consent works.
Who can participate in stem cell therapy clinical trials?
Transplant trials enroll people with a specific diagnosis who are already candidates for transplant, which means good enough organ function to tolerate it and, for donor transplants, a suitable donor. The multiple sclerosis trial enrolls adults 18 to 55 with relapsing disease that keeps progressing despite treatment. Mesenchymal cell trials enroll people with the condition being tested, such as active Crohn's disease or a chronic wound. Trials of lab grown cells for Parkinson's or diabetes are small and usually at a few centers, with strict rules. Healthy volunteers are rarely needed, except as stem cell donors in some studies. Eligibility always varies by study.
Is stem cell therapy safe?
Approved transplants carry real risks, including infection and graft versus host disease, and are done in specialized centers. Unapproved clinic injections have caused serious harm in reported cases. In a clinical trial, risks are explained during informed consent and you are monitored throughout.
How long does stem cell therapy last?
A successful transplant rebuilds the blood system permanently. For newer therapies, how long the effect lasts is exactly what trials measure, often over years of follow up.
Do stem cell trial participants get paid?
Some studies offer compensation for time and travel, and the study cell therapy and study visits are typically provided at no cost to participants; the hospital care around a transplant is usually billed as normal care. Exactly what is covered is described during the informed consent process before you agree to anything.
Curious whether clinical trials pay participants? Here's how compensation actually works.
How to enroll in a stem cell clinical trial
Enrolling in a stem cell clinical trial through our platform is a straightforward and user-friendly process. Here's how to get started:
- Identify Your Trial: Use our search function or filters to find clinical trials that match your medical condition and interest in stem cell therapy. This first step simplifies the process of finding relevant research studies tailored to your needs.
- Select Your Preferred Location: To find trials conveniently located near you, simply input your preferred location into the dedicated filter bar on the left-hand side of the page.
- Explore Study Details: For in-depth information about each study, simply click the “Learn More” button. This will provide you with comprehensive details about the trial, including objectives, procedures, and eligibility criteria.
- Complete the Health Profile: After clicking on the “Get started” button you will be taken to our efficient 5-step application process to provide important health information. This helps us match you with the clinical trial that best fits your needs.
- Submit the Application: After completing the application, send it in. A clinical trial coordinator will review it and contact you regarding the possibility of participation.