Sarcoidosis Clinical Trials

Since 1952, essentially nothing new has reached the market specifically for sarcoidosis, leaving steroids as the default option despite their long-term downsides. A large Phase 3 trial of a non-steroid approach wrapped up in 2025, the most advanced attempt in over 70 years. Whether it or anything like it eventually reaches patients depends on trials like the ones listed here continuing to enroll.

Eligibility depends heavily on which organs are involved and how you've responded to prior treatment, since a trial for lung-focused disease looks very different from one built around cardiac or neurological involvement. Many studies specifically recruit people who haven't improved on steroids alone or who can't tolerate long-term steroid use. Eligibility always varies by study.

Trials generally fall into a few groups. Some test non-steroid medicines aimed at calming the underlying inflammation, others study ways to reduce steroid side effects while keeping symptoms controlled, and some are purely observational, tracking how the disease behaves over time in different organs and populations.

No, though the lungs are involved in the large majority of cases. In a recent patient survey, skin was affected in about 30% of people, the heart in about 25%, and the eyes in about 25%. Heart involvement in particular can lead to serious complications and sometimes overlaps with symptoms of heart failure, which is part of why cardiac screening is common after diagnosis.

Yes, in a form called neurosarcoidosis, which can cause nerve pain, weakness, or vision changes depending on where the granulomas form. It's less common than lung involvement, but doctors watch for nerve related symptoms since neurosarcoidosis can be harder to diagnose than the pulmonary form.

Some studies offer compensation for time and travel, and study related care is typically provided at no cost to participants. Compensation varies by trial and is always described during the informed consent process before you agree to anything.

Curious whether clinical trials pay participants? Here's how compensation actually works.

How Much do Clinical Trials Pay? Everything You Need to Know About Getting Paid For Clinical Trials

Every study is reviewed by an independent ethics board before enrollment opens, and the risks specific to that study, whether it's an observational study or one testing a new approach, are explained to you during informed consent.

Worried about the risks of participating in a clinical trial? Delve into our comprehensive guide to gain insights into the potential outcomes of participating. Learn about potential risks, benefits, and safety considerations to make an informed decision about your participation in a clinical trial.

Clinical Trial Benefits, Risks & Safety Considerations