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Sickle Cell Clinical Trials

Browse 133 sickle cell clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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Active & Responsive

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

for
Sickle Cell Disease
Location: The Bronx NY, Philadelphia PA, Easton PA, Baltimore MD,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 12 - 70+

Code: NCT06439082

Phase3, Recruiting
Active & Responsive

FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases

for
Alpha-Thalassemia, Beta-Thalassemia, Amyloidosis,
Location: Los Altos CA
Sponsor: xCures

Sex: All

Age: 0+

Code: NCT06539169

Recruiting
Active & Responsive

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

for
Anemia, Sickle Cell, Healthy Volunteers
Location: Boston MA, New Haven CT, Philadelphia PA, Richmond VA,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT06481306

Phase1, Phase2, Recruiting
Active & Responsive

Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease

for
Sickle Cell Disease
Location: New York NY, Columbus OH, St Louis MO, Los Angeles CA,
Sponsor: Kamau Therapeutics

Sex: All

Age: 12 - 50

Code: NCT04819841

Phase1, Phase2, Recruiting
Active & Responsive

Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease

for
Sickle Cell Disease
Location: Los Angeles CA, Oakland CA
Sponsor: Mark Walters, MD

Sex: All

Age: 12 - 35

Code: NCT04774536

Phase1, Phase2, Recruiting

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Active & Responsive

Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease

for
Sickle Cell Disease
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 16 - 60

Code: NCT03121001

Phase2, Recruiting
Active & Responsive

Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

for
Sickle Cell Disease
Location: Philadelphia PA, Augusta GA, Cleveland OH,
Sponsor: RTI International

Sex: All

Age: 18+

Code: NCT06385886

Recruiting
Active & Responsive

A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)

for
Sickle Cell Disease
Location: Grand Rapids MI, Indianapolis IN, Flowood MS
Sponsor: Agios Pharmaceuticals, Inc.

Sex: All

Age: 12+

Code: NCT07656415

Phase3, Recruiting
Active & Responsive

Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin

for
Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0), Albuminuria
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 18 - 60

Code: NCT07175051

Phase2, Recruiting
Active & Responsive

Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease

for
Sickle Cell Disease, Hematopoetic Stem Cell Transplant,
Location: Atlanta GA
Sponsor: Arkansas Children's Hospital Research Institute

Sex: All

Age: 12 - 45

Code: NCT07252050

Phase1, Phase2, Recruiting
Active & Responsive

Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease

for
Sickle Cell Disease
Location: Valhalla NY, Gainesville FL, Milwaukee WI,
Sponsor: New York Medical College

Sex: All

Age: 0 - 21

Code: NCT02675959

Phase2, Recruiting
Active & Responsive

Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory Problems

for
Mild Cognitive Impairment (MCI),
Location: Toronto
Sponsor: Rotman Research Institute at Baycrest

Sex: All

Age: 55 - 70+

Code: NCT07212504

Recruiting
Active & Responsive

High Frequency Stimulation to Improve Cognition, Mobility, and Affect in Individuals With and Without Subjective Cognitive Decline

for
Subjective Cognitive Decline (SCD), Healthy Subjects
Location: Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 65 - 70+

Code: NCT07395609

Recruiting
Active & Responsive

FACE Phase II (a Stage II Trial)

for
MCI, Subjective Cognitive Decline (SCD),
Location: Palo Alto CA
Sponsor: Stanford University

Sex: All

Age: 60 - 70+

Code: NCT07130669

Phase1, Phase2, Recruiting
Active & Responsive

Comprehensive Assessment of Neurodegeneration and Dementia

for
Dementia, Mild Cognitive Impairment (MCI),
Location: Halifax, Quebec, Montreal, Toronto, Hamilton, London,
Sponsor: McGill University

Sex: All

Age: 50 - 70+

Code: NCT03402919

Recruiting

Measures of Respiratory Health (MRH)

for
Cystic Fibrosis, Asthma, Sickle Cell Anemia,
Location: Toronto
Sponsor: The Hospital for Sick Children

Sex: All

Age: 2 - 30

Code: NCT02657837

Recruiting

Virtual Reality As Adjunct Therapy for Vaso-Occlusive Pain

for
Sickle Cell Disease, Vaso-occlusive Pain Episodes
Location: New Orleans LA
Sponsor: Louisiana State University Health Sciences Center in New Orleans

Sex: All

Age: 8 - 21

Code: NCT06773715

Recruiting

A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

for
Sickle Cell Disease
Location: Boston MA, Providence RI, Philadelphia PA,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 12 - 55

Code: NCT06546670

Phase1, Phase2, Recruiting

Let's Get REAL: Family Health Communication Tool in Pediatric Stem Cell Transplant and Cellular Therapy

for
Hematologic Malignancy, Solid Tumor, Sickle Cell Disease,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 8+

Code: NCT06689800

Recruiting

Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell Antibody

for
Sickle Cell Disease
Location: Washington D.C. DC
Sponsor: Children's National Research Institute

Sex: All

Age: 2 - 25

Code: NCT06358638

Phase2, Recruiting