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Paid Clinical Trials Springfield

Discover 196 paid clinical trials in Springfield, Illinois. Search by condition or phase to find a research study near you that matches your needs across various therapeutic areas.

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Featured

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

for
Crohn's Disease
Location: Springfield IL, Peoria IL, St Louis MO, Columbia MO,
Sponsor: AbbVie

Sex: All

Age: 18 - 70+

Code: NCT06548542

Phase 2, Recruiting
Featured

Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

for
Neovascular Age-related Macular Degeneration
Location: Springfield IL, St Louis MO, Oak Lawn IL, Carmel IN,
Sponsor: AbbVie

Sex: All

Age: 50+

Code: NCT07007065

Phase 3, Recruiting
Featured

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

for
Breast Cancer
Location: Springfield IL, Urbana IL, O'Fallon IL, Zion IL,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT06790693

Phase 3, Recruiting
Featured

A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

for
Non-Small Cell Lung Cancer, c-MET
Location: Springfield IL, Chicago IL, Niles IL, Nashville TN,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT06568939

Phase 2, Recruiting
Featured

A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer

for
Small Cell Lung Cancer
Location: Springfield IL, Peoria IL, Chicago IL, Indianapolis IN,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT07365241

Phase 3, Recruiting

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Featured

Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema

for
Diabetic Retinopathy
Location: Springfield IL, Oak Forest IL, Chicago IL, Lenexa KS,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT07592273

Phase 2, Phase 3, Recruiting
Active & Responsive

Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for
Anatomic Stage I Breast Cancer AJCC v8,
Location: Springfield IL, Decatur IL, Pekin IL, Canton IL,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT05929768

Phase 3, Recruiting
Active & Responsive

Safety and Efficacy Study of ICXP007 With Compression Bandaging for the Treatment of Non-Infected Venous Leg Ulcers

for
Leg Ulcer
Location: Springfield IL, Niles IL, North Chicago IL, Columbus OH,
Sponsor: Intercytex

Sex: All

Age: 18+

Code: NCT00232973

Phase 3, Recruiting
Active & Responsive

THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension

for
Hypertension
Location: Springfield IL, Elk Grove Village IL, Kansas City MO,
Sponsor: SoniVie Inc.

Sex: All

Age: 22 - 70+

Code: NCT06559891

Recruiting
Active & Responsive

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

for
Atherosclerotic Cardiovascular Disease, Overweight, Obesity
Location: Springfield IL, St Louis MO, City of Saint Peters MO,
Sponsor: Amgen

Sex: All

Age: 45 - 70+

Code: NCT07037433

Phase 3, Recruiting
Active & Responsive

Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

for
Obesity or Overweight
Location: Springfield IL, Skokie IL, Troy MI, Pelham AL,
Sponsor: Amgen

Sex: All

Age: 18 - 70+

Code: NCT07575399

Phase 3, Recruiting
Active & Responsive

Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG

for
Hypertension, Pulmonary,
Location: Springfield IL, O'Fallon IL, Norfolk VA
Sponsor: Eko Devices, Inc.

Sex: All

Age: 18+

Code: NCT07087613

Recruiting
Active & Responsive

Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease

for
Chronic Granulomatous Disease (CGD)
Location: Springfield IL, Jefferson City MO, Indianapolis IN,
Sponsor: Ensoma

Sex: All

Age: 0+

Code: NCT06605378

Recruiting
Active & Responsive

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

for
Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma
Location: Springfield IL, Decatur IL, Normal IL, Peoria IL,
Sponsor: National Cancer Institute (NCI)

Sex: Female

Age: 18+

Code: NCT07198074

Phase 3, Recruiting
Active & Responsive

A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA)

for
Geographic Atrophy Secondary to Age-related Macular Degeneration,
Location: Springfield IL, Oak Forest IL, La Crosse WI, Dallas TX,
Sponsor: Complement Therapeutics

Sex: All

Age: 55+

Code: NCT07144137

Recruiting
Active & Responsive

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

for
Metastatic Dedifferentiated Liposarcoma,
Location: Springfield IL, Decatur IL, Pekin IL, Canton IL,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06422806

Phase 3, Recruiting
Active & Responsive

Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial

for
Advanced Esophageal Adenocarcinoma,
Location: Springfield IL, Decatur IL, Effingham IL, Mattoon IL,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06203600

Phase 2, Phase 3, Recruiting
Active & Responsive

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

for
Clinical Stage III Cutaneous Melanoma AJCC v8,
Location: Springfield IL, Decatur IL, Pekin IL, Canton IL,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05136196

Phase 2, Recruiting
Active & Responsive

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

for
Recurrent Head and Neck Squamous Cell Carcinoma,
Location: Springfield IL, Decatur IL, Effingham IL, Mattoon IL,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT04671667

Phase 2, Recruiting
Active & Responsive

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

for
Metastatic Head and Neck Squamous Cell Carcinoma,
Location: Springfield IL, Decatur IL, Normal IL, Peoria IL,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06589804

Phase 3, Recruiting