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ASTX727, Venetoclax, and Gilteritinib for the Treatment of Newly Diagnosed, Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

for
Acute Myeloid Leukemia, Myelodysplastic Syndrome,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05010122

Phase1, Phase2, Recruiting

Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

for
Acute Myeloid Leukemia,
Location: Boston MA, Cleveland OH, Houston TX, Portland OR
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03471260

Phase1, Phase2, Recruiting

CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia

for
Recurrent Acute Myeloid Leukemia,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT04375631

Phase1, Recruiting

Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy

for
Acute Myeloid Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 1+

Code: NCT03630991

Phase1, Recruiting

Quizartinib, Decitabine, and Venetoclax in Treating Participants With Untreated or Relapsed Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

for
Acute Myeloid Leukemia, Myelodysplastic Syndrome,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03661307

Phase1, Phase2, Recruiting

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Ruxolitinib in Combination With Venetoclax With and Without Azacitidine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

for
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome,
Location: Portland OR
Sponsor: Jennifer Saultz

Sex: All

Age: 18+

Code: NCT03874052

Phase1, Recruiting

HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

for
Juvenile Myelomonocytic Leukemia,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 0 - 70+

Code: NCT03326921

Phase1, Recruiting

Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse

for
Acute Myeloid Leukemia, Acute Undifferentiated Leukemia,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT06928662

Phase1, Phase2, Recruiting

Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation

for
Acute Bilineal Leukemia, Acute Biphenotypic Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03683433

Phase2, Recruiting

Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

for
Acute Myeloid Leukemia, Myelodysplastic Syndrome,
Location: Boston MA, New Haven CT, Commack NY, Uniondale NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06484062

Phase1, Recruiting

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

for
Acute Lymphoblastic Leukemia in Remission,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18 - 70+

Code: NCT03670966

Phase1, Phase2, Recruiting

Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT

for
Leukemia, High Risk Acute Lymphoblastic Leukemia,
Location: Philadelphia PA
Sponsor: Children's Hospital of Philadelphia

Sex: All

Age: 0 - 25

Code: NCT06839456

Phase1, Phase2, Recruiting

MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing

for
Leukemia, Acute Myeloid Leukemia in Remission, Myelodysplasia,
Location: Milwaukee WI
Sponsor: Medical College of Wisconsin

Sex: All

Age: 0 - 25

Code: NCT05794880

Recruiting

Venetoclax Basket Trial for High Risk Hematologic Malignancies

for
Myelodysplastic Syndromes, de Novo,
Location: Boston MA, Atlanta GA, Chicago IL, Aurora CO,
Sponsor: Andrew E. Place, MD

Sex: All

Age: 1 - 40

Code: NCT05292664

Phase1, Recruiting

Allo HSCT Using RIC and PTCy for Hematological Diseases

for
Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 0 - 70+

Code: NCT05805605

Phase2, Recruiting

Clinical Study of ARD103 CAR-T Therapy for Patients With R/R AML or MDS

for
Acute Myeloid Leukemia, in Relapse,
Location: Winston-Salem NC, Charlotte NC, Houston TX
Sponsor: ARCE Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06680752

Phase1, Phase2, Recruiting
New

Total Marrow and Lymphoid Irradiation in Combination With Fludarabine and Melphalan as Conditioning for Allogeneic Peripheral Blood Stem Cell Hematopoietic Cell Transplant in Older Patients With Refractory and Relapsed Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome

for
Acute Myeloid Leukemia With Complex Karyotype,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07582172

Phase2, Recruiting