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Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV

for
HIV, Immunodeficiencies, Infectious Diseases
Location: Bethesda MD
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All

Age: 18 - 70+

Code: NCT00001281

Recruiting

Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy

for
HIV-1-infection, Hepatitis C, Chronic, Methadone Dependence,
Location: Regina
Sponsor: Saskatchewan Health Authority - Regina Area

Sex: All

Age: 18+

Code: NCT03549312

Recruiting

A Long-term Extension Study of PCI-32765 (Ibrutinib)

for
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma,
Location: Columbus OH, Sioux Falls SD, Orange CA, Eugene OR
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT01804686

Phase3, Recruiting

Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases

for
Focal Segmental Glomerulosclerosis, Minimal Change Disease,
Location: New Hyde Park NY, Neptune City NJ, Hackensack NJ,
Sponsor: Travere Therapeutics, Inc.

Sex: All

Age: 1 - 17

Code: NCT05003986

Phase2, Recruiting

Study of the ITK Inhibitor Soquelitinib to Reduce Lymphoproliferation and Improve Cytopenias in Autoimmune Lymphoproliferative Syndrome (ALPS)-FAS Patients

for
Autoimmune Lymphoproliferative Syndrome
Location: Philadelphia PA, Bethesda MD, Houston TX
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All

Age: 16 - 70+

Code: NCT06730126

Phase2, Recruiting

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Metformin for HIV Inflammation

for
HIV, Coronary Artery Disease
Location: Honolulu HI
Sponsor: University of Hawaii

Sex: All

Age: 45+

Code: NCT02383563

Phase2, Recruiting

Observational Pharmaco-Epidemiology Research & Analysis

for
Chronic Disease, HIV/AIDS, Liver Diseases,
Location: Durham NC
Sponsor: Epividian

Sex: All

Age: 0+

Code: NCT03813862

Recruiting

Extension Study of Two Doses of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)

for
Thyroid Eye Disease, Graves Orbitopathy,
Location: Miami FL, Morgantown WV
Sponsor: Sling Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06112340

Phase2, Phase3, Recruiting

IS-free Treg HaploHCT

for
Stem Cell Transplant Complications, Graft Vs Host Disease,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18 - 70+

Code: NCT04678401

Phase1, Recruiting

A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

for
Graves' Disease
Location: Boston MA, Monroe NY, Pottstown PA, Newark DE,
Sponsor: Immunovant Sciences GmbH

Sex: All

Age: 18 - 70+

Code: NCT06727604

Phase2, Recruiting

Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease

for
Human Immunodeficiency Virus, Castleman's Disease,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT03300830

Recruiting

A Study of Treatment of Inflammation Before Stem Cell Transplant in People With a Primary Immune Regulatory Disorder (PIRD) and/or an Autoinflammatory Condition

for
Primary Immune Regulatory Disorder,
Location: New York NY, Philadelphia PA, Atlanta GA, Milwaukee WI,
Sponsor: Joseph Oved

Sex: All

Age: 0+

Code: NCT05787574

Phase2, Recruiting

Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention

for
HIV Infections, Sexually Transmitted Diseases
Location: Washington DC, Miami FL, San Francisco CA
Sponsor: Public Health Foundation Enterprises, Inc.

Sex: All

Age: 15+

Code: NCT04855773

Recruiting

Evaluation of Patients With Immune Function Abnormalities

for
Chronic Granulomatous Disease (CGD),
Location: Bethesda MD
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All

Age: 0+

Code: NCT00128973

Recruiting

Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)

for
Dyslipidemias, Cardiovascular Diseases, HIV Infections,
Location: Houston TX, Los Angeles CA, San Francisco CA
Sponsor: Priscilla Hsue, MD

Sex: All

Age: 40+

Code: NCT05488431

Phase2, Recruiting

A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier Homeostasis

for
Inflammatory Bowel Disease
Location: Charleston SC, Chicago IL
Sponsor: Rush University Medical Center

Sex: All

Age: 18+

Code: NCT05579392

Recruiting

Duloxetine in Inflammatory Bowel Diseases

for
Inflammatory Bowel Diseases
Location: Philadelphia PA
Sponsor: University of Pennsylvania

Sex: All

Age: 24+

Code: NCT07431606

Phase2, Recruiting

A Study to Evaluate the Use of Resmetirom in Participants With MASLD and HIV

for
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease,
Location: Baltimore MD, West Palm Beach FL, Indianapolis IN,
Sponsor: Naga P. Chalasani

Sex: All

Age: 18+

Code: NCT07143968

Phase2, Recruiting

Cord Blood Transplantation in Children and Young Adults With Blood Cancer

for
Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia,
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 0 - 26

Code: NCT07566377

Phase2, Recruiting

COMPARE - Pediatric Inflammatory Bowel Disease (PIBD)

for
Ulcerative Colitis, Pediatric, Inflammatory Bowel Diseases,
Location: Durham NC, Chapel Hill NC, Pittsburgh PA, Charlotte NC
Sponsor: University of North Carolina, Chapel Hill

Sex: All

Age: 1 - 18

Code: NCT07198113

Recruiting