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Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial

for
Recurrent Castration-Sensitive Prostate Carcinoma,
Location: Jacksonville FL, Rochester MN, Phoenix AZ
Sponsor: Mayo Clinic

Sex: Male

Age: 18+

Code: NCT06378866

Phase2, Recruiting

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

for
Metastatic Castration-resistant Prostate Cancer (mCRPC),
Location: New Haven CT, Quebec, New Brunswick NJ, Montreal,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06136650

Phase3, Recruiting

Study of TVB-2640 in Men With Metastatic Castration-Resistant Prostate Cancer

for
Prostatic Neoplasms, Castration-Resistant
Location: New York NY
Sponsor: Weill Medical College of Cornell University

Sex: Male

Age: 18+

Code: NCT05743621

Phase1, Recruiting

Low PSMA SUV Boost (LPS-Boost): Intensified 177Lu-PSMA-617 Treatment for Patients With Metastatic Castrate-Resistant Prostate Cancer With Low PSMA Expressing Disease

for
Metastatic Castration-Resistant Prostate Carcinoma,
Location: Seattle WA, San Francisco CA
Sponsor: University of Washington

Sex: Male

Age: 18+

Code: NCT06526299

Phase2, Recruiting

Cabozantinib and Atezolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer

for
Castration-Resistant Prostate Carcinoma,
Location: Salt Lake City UT
Sponsor: University of Utah

Sex: Male

Age: 18+

Code: NCT05168618

Phase2, Recruiting

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Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer

for
Castration-Resistant Prostate Carcinoma,
Location: Baltimore MD, Madison WI, Seattle WA
Sponsor: University of Washington

Sex: Male

Age: 18+

Code: NCT04489719

Recruiting

Ruxolitinib and Enzalutamide for the Treatment of Metastatic Castration-Resistant Prostate Cancer

for
Castration-Resistant Prostate Carcinoma,
Location: Ann Arbor MI
Sponsor: University of Michigan Rogel Cancer Center

Sex: Male

Age: 18+

Code: NCT06616155

Phase1, Phase2, Recruiting

Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)

for
Prostatic Neoplasms, Castration-Resistant
Location: Quebec, Montreal, Miami FL, Cleveland OH, Milwaukee WI,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06353386

Phase1, Phase2, Recruiting

Cell Therapy (STEAP1 CART) With Enzalutamide for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer

for
Metastatic Castration-Resistant Prostate Carcinoma,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: Male

Age: 18+

Code: NCT06236139

Phase1, Phase2, Recruiting

64Cu-SAR-bisPSMA and 67Cu-SAR-bisPSMA for Identification and Treatment of PSMA-expressing Metastatic Castrate Resistant Prostate Cancer (SECuRE)

for
Prostatic Neoplasms, Castration-Resistant
Location: New York NY, Grand Rapids MI, River Ridge LA,
Sponsor: Clarity Pharmaceuticals Ltd

Sex: Male

Age: 18+

Code: NCT04868604

Phase1, Phase2, Recruiting

A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

for
Prostatic Neoplasms, Castration-Resistant
Location: Quebec, Mineola NY, The Bronx NY, New York NY,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT07225946

Phase3, Recruiting

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

for
Metastatic Castration-Resistant Prostate Carcinoma,
Location: Commack NY, Uniondale NY, Harrison NY, The Bronx NY,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: Male

Age: 18+

Code: NCT07200830

Phase3, Recruiting

An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01)

for
Progressive Metastatic Castrate Resistant Prostate Cancer
Location: Halifax, Boston MA, Durham NC, Cleveland OH, Atlanta GA,
Sponsor: Novartis Pharmaceuticals

Sex: Male

Age: 18+

Code: NCT07206056

Phase1, Phase2, Recruiting

Personalized vs. Fixed-Activity 177Lu-PSMA-617 Radiopharmaceutical Therapy (PRODIGY-2)

for
Metastatic Castrate Resistant Prostate Cancer (mCRPC)
Location: Quebec
Sponsor: Jean-Mathieu Beauregard

Sex: Male

Age: 18+

Code: NCT06943495

Phase1, Recruiting

SPECT/CT Imaging for Dosimetry in 177Lu-PSMA-617 (Pluvicto) Therapy

for
Metastatic Castration-Resistant Prostate Carcinoma
Location: Ann Arbor MI
Sponsor: University of Michigan Rogel Cancer Center

Sex: Male

Age: 18+

Code: NCT07096999

Recruiting

Imaging of Solid Tumors Using 18F-TRX

for
Solid Tumor, Solid Carcinoma,
Location: San Francisco CA
Sponsor: Rahul Aggarwal

Sex: All

Age: 18+

Code: NCT06942104

Phase1, Recruiting

Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer

for
Hormone-refractory Prostate Cancer
Location: Fairfax VA, Houston TX, Seattle WA, Orange CA,
Sponsor: Astellas Pharma Global Development, Inc.

Sex: Male

Age: 18+

Code: NCT05997615

Phase1, Recruiting

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

for
Castration-Resistant Prostate Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04693377

Recruiting

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

for
Castration-Resistant Prostate Carcinoma,
Location: South Weymouth MA, Foxborough MA, Methuen MA,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 18+

Code: NCT06632977

Phase2, Recruiting

Supraphysiological Androgen to Enhance Treatment Activity in Metastatic Castration-Resistant Prostate Cancer, SPECTRA Study

for
Castration-Resistant Prostate Carcinoma,
Location: Seattle WA
Sponsor: University of Washington

Sex: Male

Age: 18+

Code: NCT06039371

Phase2, Recruiting