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Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

for
Barrett Esophagus, Esophageal Adenocarcinoma
Location: Eau Claire WI, Rochester MN, Austin MN
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 70+

Code: NCT03961945

Recruiting

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

for
Gastric Cancer, Gastroesophageal Junction Cancer
Location: Boston MA, The Bronx NY, New York NY, Hershey PA,
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT06731478

Phase3, Recruiting

A Phase 1 Study of the Safety and Tolerability of CTX-10726

for
Gastroesophageal Cancer (GC), Hepatocellular Carcinoma (HCC),
Location: Lake Success NY, Pittsburgh PA, Greenville SC,
Sponsor: Compass Therapeutics

Sex: All

Age: 18+

Code: NCT07419841

Phase1, Recruiting

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

for
Melanoma, Non-small Cell Lung Cancer,
Location: Fairfax VA, Pittsburgh PA, Grand Rapids MI, St Louis MO,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07115043

Phase1, Phase2, Recruiting

Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors

for
Clinical Stage III Gastric Cancer AJCC v8,
Location: Houston TX
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06364410

Phase1, Recruiting

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Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

for
Solid Tumor, Advanced Cancer, Metastatic Cancer, Gastric Cancer,
Location: Boston MA, Goodyear AZ, Duarte CA
Sponsor: I-Mab Biopharma US Limited

Sex: All

Age: 18+

Code: NCT07432295

Phase2, Recruiting

RAPA-201 Therapy of Solid Tumors

for
Solid Tumor, Small Cell and Non-small Cell Lung Cancer,
Location: Hackensack NJ
Sponsor: Rapa Therapeutics LLC

Sex: All

Age: 18+

Code: NCT05144698

Phase1, Phase2, Recruiting

Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma

for
Esophageal Adenocarcinoma, Gastric Adenocarcinoma,
Location: New York NY, Philadelphia PA
Sponsor: Weill Medical College of Cornell University

Sex: All

Age: 18+

Code: NCT06340711

Phase2, Recruiting

Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or ICI, for the Treatment of Patients With Advanced Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)

for
Gastric or Gastroesophageal Junction Adenocarcinoma,
Location: Fairfax VA, Durham NC, Pittsburgh PA, Louisville KY,
Sponsor: Phanes Therapeutics

Sex: All

Age: 18+

Code: NCT05482893

Phase1, Phase2, Recruiting

Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples

for
Barrett Esophagus, Barretts Esophagus With Dysplasia,
Location: Jacksonville FL, Rochester MN, Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 70+

Code: NCT06071845

Recruiting

Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma

for
Clinical Stage I Esophageal Adenocarcinoma AJCC v8,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06078709

Phase2, Recruiting

A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer

for
Gastric Adenocarcinoma, Gastric Cancer,
Location: Plano TX, Dallas TX, Grapevine TX, Arlington TX,
Sponsor: Toray Industries, Inc

Sex: All

Age: 18+

Code: NCT06038578

Phase2, Recruiting

A Phase 1/1b Study of IAM1363 in HER2 Cancers

for
HER2 Mutation-Related Tumors, HER2, HER2-positive Breast Cancer,
Location: Boston MA, Lebanon NH, New York NY, New Brunswick NJ,
Sponsor: Iambic Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06253871

Phase1, Recruiting

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

for
Carcinoma, Non-Small Cell Lung,
Location: Boston MA, Newton MA, Shirley NY, Riverhead NY,
Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All

Age: 18+

Code: NCT04389632

Phase1, Recruiting

Advanced Endo-therapeutic Procedure : Registry-based Observational Study

for
Zenker Diverticulum, Polyp of Colon, Colo-rectal Cancer
Location: Montreal
Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All

Age: 18+

Code: NCT04117100

Recruiting

Trans-Pacific Multicenter Collaborative Study of Minimally Invasive Proximal Versus Total Gastrectomy for Proximal Gastric and Gastroesophageal Junction Cancers

for
Gastrostomy, Gastric, GastroEsophageal Cancer
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05205343

Recruiting

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

for
Cancer Pain, Visceral Pain, Gastrointestinal Neoplasms,
Location: Los Angeles CA
Sponsor: Cedars-Sinai Medical Center

Sex: All

Age: 18 - 70+

Code: NCT04907643

Recruiting

A Phase â…¢ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer

for
Gastroesophageal-junction Cancer, Monoclonal Antibody,
Location: Sayre PA, West Palm Beach FL, Pompano Beach FL,
Sponsor: Shanghai Henlius Biotech

Sex: All

Age: 18+

Code: NCT06532006

Phase3, Recruiting

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

for
Solid Tumors, Advanced Cancer, Renal Cancer, Gastric Cancer,
Location: Montreal, Hershey PA, Chapel Hill NC, Toronto,
Sponsor: Apollomics Inc.

Sex: All

Age: 18+

Code: NCT03175224

Phase2, Recruiting

Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

for
Barretts Esophagus With Dysplasia, Barrett Esophagus,
Location: Boston MA, Lebanon NH, Manhasset NY, New York NY,
Sponsor: University of Colorado, Denver

Sex: All

Age: 18 - 70+

Code: NCT05753748

Recruiting