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Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

for
Gastroesophageal Junction, Gastroesophageal Adenocarcinoma,
Location: East Syracuse NY, Pittsburgh PA, Grand Rapids MI,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06469944

Phase1, Phase2, Recruiting

Liquid Nitrogen Spray Cryotherapy Prior to Neoadjuvant Systemic Therapy in Esophageal Adenocarcinoma

for
Esophageal Adenocarcinoma, Esophageal Cancer
Location: Weston FL
Sponsor: Case Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT07222657

Phase2, Recruiting

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

for
Non-Small-Cell Lung, Esophageal Cancer, Cutaneous Melanoma
Location: New Haven CT, Trumbull CT, Fairfax VA, Nashville TN,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07519655

Phase1, Recruiting

Distance-Based Exercise to Preserve Function and Prevent Disability

for
Localized Malignant Solid Neoplasm, Anal Cancer,
Location: Boston MA, Indiana PA, Kernersville NC,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 18+

Code: NCT07059884

Recruiting

Volume Outcome Relationships and Effects

for
Esophageal Cancer
Location: Richardson TX
Sponsor: Methodist Health System

Sex: All

Age: 18+

Code: NCT06343597

Recruiting

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma,
Location: Moncton, Quebec, New York NY, East Brunswick NJ,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07431281

Phase3, Recruiting

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors

for
Lung Cancer (NSCLC), Prostate Cancer, Esophageal Cancer,
Location: Orlando FL, Nashville TN, Houston TX
Sponsor: Phrontline Biopharma

Sex: All

Age: 18+

Code: NCT07181473

Phase1, Recruiting

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

for
Esophageal Cancer, Gastric Cancer (GC),
Location: Boston MA, Worcester MA, New York NY, Philadelphia PA,
Sponsor: SOFIE

Sex: All

Age: 18+

Code: NCT07217704

Phase3, Recruiting

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

for
Head and Neck Squamous Cell Carcinoma HNSCC,
Location: Boston MA, New York NY, Washington D.C. DC, Fairfax VA,
Sponsor: Sutro Biopharma, Inc.

Sex: All

Age: 18+

Code: NCT07227168

Phase1, Recruiting

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

for
Renal Cell Carcinoma, Non Small Cell Lung Cancer, Melanoma,
Location: Pittsburgh PA
Sponsor: Diwakar Davar

Sex: All

Age: 18+

Code: NCT07223424

Phase2, Recruiting

DESTINY-PANTUMOUR04

for
Adenocarcinoma (NOS), Anal Cancer, Bladder Cancer,
Location: Philadelphia PA, Wilson NC, Durham NC,
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT07124000

Recruiting

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

for
Advanced/Metastatic Solid Tumors, Bladder Cancer,
Location: Boston MA, Newton MA, New Haven CT, Trumbull CT,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07090499

Phase1, Recruiting

Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow

for
Non Small Cell Lung Cancer, Esophageal Cancer, Gastric Cancer,
Location: Columbia MO
Sponsor: University of Missouri-Columbia

Sex: All

Age: 18+

Code: NCT03551951

Recruiting

Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)

for
Gastrointestinal Cancer, Gastric Cancer, Esophageal Cancer,
Location: Los Angeles CA
Sponsor: Cedars-Sinai Medical Center

Sex: All

Age: 18+

Code: NCT07124351

Recruiting

A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

for
Colorectal Cancer, Non-Small Cell Lung Cancer, Breast Cancer,
Location: Boston MA, New Haven CT, Sarasota FL, Irving TX
Sponsor: Immunome, Inc.

Sex: All

Age: 18+

Code: NCT07578571

Phase1, Recruiting

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

for
Metastatic Solid Tumor, Recurrent Solid Tumor,
Location: Boston MA, New York NY, Cleveland OH, Grand Rapids MI,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06465069

Phase1, Recruiting

Intra-tumoral (IT) Injection of vvDD-hIL2-2-RG-1 for Metastatic Gastrointestinal and Peritoneal Tumors

for
Gastric Neoplasms, Esophageal Cancer, Liver Cancer,
Location: Pittsburgh PA
Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Sex: All

Age: 18 - 69

Code: NCT07001592

Phase1, Recruiting

Impact of Prehabilitation in Oncology Via Exercise- Esophageal (IMPROVE-Esophageal)

for
Esophageal Cancer, Esophageal Carcinoma
Location: Pittsburgh PA
Sponsor: University of Pittsburgh

Sex: All

Age: 18+

Code: NCT06872515

Recruiting

Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux

for
Obese Patients, Tobacco Use, Veterans,
Location: Cleveland OH
Sponsor: Cleveland VA Medical Research and Education Foundation

Sex: All

Age: 40 - 70+

Code: NCT06746623

Recruiting

PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer

for
Esophageal Cancer, Oesophageal Cancer, GastroEsophageal Cancer
Location: Milwaukee WI
Sponsor: Medical College of Wisconsin

Sex: All

Age: 18+

Code: NCT06906887

Phase2, Recruiting