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Active & Responsive

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

for
Myelofibrosis; Anemia, Anemia, Myelofibrosis,
Location: New York NY, Philadelphia PA, Miami FL,
Sponsor: Disc Medicine, Inc

Sex: All

Age: 18+

Code: NCT05320198

Phase1, Phase2, Recruiting
Active & Responsive

Reparixin in Patients With Myelofibrosis Myeloproliferative Neoplasms Research Consortium (MPN-RC 120)

for
Myelofibrosis (PMF),
Location: New York NY, Buffalo NY, Winston-Salem NC, Tampa FL,
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All

Age: 18+

Code: NCT05835466

Phase2, Recruiting
Active & Responsive

A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)

for
Primary Myelofibrosis (PMF),
Location: New Haven CT, Albany NY, Berkeley Heights NJ,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07357727

Phase3, Recruiting

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis

for
Primary Myelofibrosis,
Location: New York NY, Toronto, Montreal, Ann Arbor MI,
Sponsor: GlaxoSmithKline

Sex: All

Age: 18+

Code: NCT06517875

Phase2, Recruiting

Myeloproliferative Neoplasms (MPNs) Patient Registry

for
Primary Myelofibrosis, Polycythemia Vera,
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 0+

Code: NCT02760238

Recruiting

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MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)

for
Polycythemia Vera, ET (Essential Thrombocythemia),
Location: New York NY, Chicago IL
Sponsor: MPN Research Foundation

Sex: All

Age: 18+

Code: NCT07362225

Recruiting

MethoTRExATE in MyelOpRolifErative Neoplasms (TREATMORE) Trial

for
Polycythemia Vera (PV), Essential Thrombocythemia (ET),
Location: New York NY
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All

Age: 18+

Code: NCT06541249

Phase2, Recruiting

Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms

for
Clonal Cytopenia of Undetermined Significance,
Location: Los Angeles CA
Sponsor: University of Southern California

Sex: All

Age: 18+

Code: NCT06063486

Phase2, Recruiting

Study of KRT-232 or TL-895 in Janus Associated Kinase Inhibitor Treatment-Naïve Myelofibrosis

for
Primary Myelofibrosis (PMF),
Location: Canton OH, Houston TX, Whittier CA, Glendale CA
Sponsor: Kartos Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT04878003

Phase2, Recruiting

KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment

for
Primary Myelofibrosis (PMF),
Location: Brooklyn NY, New York NY, Canton OH, Nashville TN,
Sponsor: Kartos Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT03662126

Phase2, Phase3, Recruiting

An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms

for
Myeloproliferative Neoplasm, MPN, Essential Thrombocythemia,
Location: Irvine CA
Sponsor: University of California, Irvine

Sex: All

Age: 18+

Code: NCT05123365

Phase1, Phase2, Recruiting

A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

for
Thrombocythemia, Essential, Primary Myelofibrosis,
Location: Durham NC, Pittsburgh PA, Columbus OH, Ann Arbor MI
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06351631

Phase3, Recruiting

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

for
Accelerated Phase Myeloproliferative Neoplasm,
Location: New York NY, Richmond VA, North Miami FL,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06661915

Phase2, Recruiting

A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms

for
Polycythemia Vera (PV), Myelofibrosis (MF),
Location: Philadelphia PA, Coral Springs FL, Tampa FL,
Sponsor: Prelude Therapeutics

Sex: All

Age: 18+

Code: NCT07469891

Phase1, Recruiting

Two Step Haplo With Radiation Conditioning

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Philadephia PA
Sponsor: Thomas Jefferson University

Sex: All

Age: 18+

Code: NCT05031897

Phase2, Recruiting

A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia

for
Essential Thrombocythemia
Location: Greenbrae CA
Sponsor: Incyte Corporation

Sex: All

Age: 18+

Code: NCT07623200

Phase3, Recruiting

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

for
Acute Myeloid Leukemia, Essential Thrombocythemia,
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 18+

Code: NCT04282187

Phase2, Recruiting

A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)

for
Primary Myelofibrosis,
Location: Boston MA, New York NY, Charlotte NC, Tampa FL,
Sponsor: Ajax Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06343805

Phase1, Recruiting

Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm

for
Myelofibrosis, Essential Thrombocythemia, MPN
Location: New York NY
Sponsor: Marina Kremyanskaya

Sex: All

Age: 18+

Code: NCT05025488

Phase1, Recruiting

Ruxolitinib in Thrombocythemia and Polycythemia Vera

for
Essential Thrombocythemia, Polycythemia Vera
Location: Danvers MA, Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT04644211

Phase2, Recruiting