A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia
for
Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Location: Columbus OH, Rochester MN, Salt Lake City UT
Sponsor: Hoffmann-La Roche
Sex: All
Age: 18+
Code: NCT05091424
Phase1, Recruiting
Active & ResponsiveNew
Venetoclax Plus Zanubrutinib for the Treatment of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
for
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Location: Columbus OH
Sponsor: Kerry Rogers
Sex: All
Age: 18+
Code: NCT07734038
Phase2, Recruiting
Active & Responsive
Tafasitamab, Acalabrutinib, and Obinutuzumab for the Treatment of Previously Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
for
Chronic Lymphocytic Leukemia
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute
Sex: All
Age: 18+
Code: NCT05943496
Phase1, Recruiting
Active & Responsive
Zanubrutinib and Lisocabtagene Maraleucel for the Treatment of Richter's Syndrome
Location: New York NY, Columbus OH, Salt Lake City UT
Sponsor: Aseel Alsouqi
Sex: All
Age: 18+
Code: NCT05873712
Phase2, Recruiting
Active & Responsive
A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants With Chronic Lymphocytic Leukemia (CLL) and Other B-cell Malignancies
for
Chronic Lymphocytic Leukemia, B-cell Malignancies
Location: Florham Park NJ, Miami Beach FL, Pittsburgh PA,
Sponsor: Curis, Inc.
Sex: All
Age: 18+
Code: NCT07271667
Phase2, Recruiting
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Active & Responsive
Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV)
for
Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated IGHV,
Location: Toronto, Calgary
Sponsor: AstraZeneca
Sex: All
Age: 18
Code: NCT07509151
Phase3, Recruiting
Active & Responsive
A Study of Lonitoclax (ZE50-0134) in Relapsed or Refractory B-cell Malignancies
for
CLL / SLL, CLL (Chronic Lymphocytic Leukemia),
Location: Chapel Hill NC, Columbus OH, Cincinnati OH,
Sponsor: Lomond Therapeutics Holdings, Inc.
Sex: All
Age: 18+
Code: NCT06708897
Phase1, Recruiting
Active & Responsive
Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib
for
Chronic Lymphocytic Leukemia (CLL),
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Sex: All
Age: 18 - 70+
Code: NCT07428707
Early_phase1, Recruiting
Active & Responsive
Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
for
CLL/SLL
Location: Boston MA, Charlotte NC, Jacksonville FL, Canton OH,
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).
for
Leukemia, Lymphocytic, Chronic, B-Cell,
Location: Moncton, Sherbrooke, Albany NY, Greenfield Park,
Sponsor: Merck Sharp & Dohme LLC
Sex: All
Age: 18+
Code: NCT05947851
Phase3, Recruiting
A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma
Study of NX-5948 in Combination With Other Agents in Adults With B-cell Malignancies
for
B-cell Lymphoma, Chronic Lymphocytic Leukemia,
Location: Nashville TN, Aurora CO, Eugene OR
Sponsor: Nurix Therapeutics, Inc.
Sex: All
Age: 18+
Code: NCT07520006
Phase1, Phase2, Recruiting
New
Study of NX-5948 Versus Pirtobrutinib in R/R CLL/SLL
for
B-cell Lymphoma, Chronic Lymphocytic Leukemia,
Location: Fairfax VA, Macon GA, Fort Wayne IN, Indianapolis IN,
Sponsor: Nurix Therapeutics, Inc.
Sex: All
Age: 18+
Code: NCT07516093
Phase3, Recruiting
Acalabrutinib and Venetoclax With or Without Early Obinutuzumab for the Treatment of High Risk, Recurrent, or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma