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Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

for
Advanced Biliary Tract Carcinoma,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT07405086

Recruiting

Lorlatinib Plus Local Consolidation Therapy In ALK Positive Advanced Non-Small Cell Lung Cancer

for
Advanced Non-Small Cell Lung Cancer
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT07415005

Phase2, Recruiting

A Study of Ivonescimab in Combination With Dato-DXd or Osimertinib in People With Non-Small Cell Lung Cancer

for
Non-Small Cell Lung Cancer
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07535437

Phase1, Phase2, Recruiting

A Study of Ivonescimab, Chemotherapy, and Stereotactic Radiosurgery for People With Non-Small Cell Lung Cancer

for
Non-Small Cell Lung Cancer
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07535463

Phase1, Phase2, Recruiting

CARE Tool Study Aim 3

for
Gynecologic Cancer, Prostate Cancer, Lung Cancer,
Location: Alton IL, St Louis MO, Rolla MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT07296887

Recruiting

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MOnaliZumab in Combination With durvAlumab (MEDI4736) for tRreatmenT of Small Cell Lung Cancer

for
Small Cell Lung Cancer, SCLC,
Location: Charlottesville VA, Detroit MI, Indianapolis IN,
Sponsor: Hirva Mamdani

Sex: All

Age: 18+

Code: NCT05903092

Phase2, Recruiting

Pilot Study of Bone Mineral Density Changes During Anti-PD-1 Immunotherapy

for
Breast Cancer (Triple Negative Breast Cancer (TNBC)),
Location: Nashville TN
Sponsor: Jessica Mezzanotte Sharpe

Sex: All

Age: 18+

Code: NCT07555210

Recruiting

A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

for
Non-Small Cell Lung Cancer
Location: Fairfax VA, Atlanta GA, Santa Monica CA
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07098338

Phase2, Recruiting

Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

for
Non-small Cell Lung Cancer (NSCLC)
Location: Halifax, Moncton, South Portland ME, Boston MA,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07291037

Phase3, Recruiting

Rural Illinois Lung Cancer Screening Initiative

for
Lung Cancer
Location: Springfield IL
Sponsor: Southern Illinois University

Sex: All

Age: 50 - 70+

Code: NCT06084078

Recruiting

Hyperpolarized Xenon-129 Magnetic Resonance Imaging in Lung Cancer Patients Receiving Radiation Therapy for Investigating Radiation-response and Toxicity

for
Lung Cancer
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06909201

Recruiting

Clinical Trial of CD40L-Augmented TIL for Patients With EGFR, ALK, ROS1 or HER2-Driven NSCLC

for
Non Small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer,
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT05681780

Phase1, Recruiting

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

for
Non-small Cell Lung Cancer (NSCLC)
Location: Quebec, Westbury NY, New York NY, Montreal, Norfolk VA,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT07361497

Phase3, Recruiting

A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

for
Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer,
Location: Baltimore MD, Washington D.C. DC, Jacksonville FL,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07154290

Phase2, Recruiting

A Phase 1/2 Study of TRI-611 in ALK-Positive NSCLC

for
ALK-positive NSCLC, ALK-Positive Lung Cancer,
Location: Boston MA, New York NY, Fairfax VA, Durham NC,
Sponsor: TRIANA Biomedicines, Inc.

Sex: All

Age: 18+

Code: NCT07491497

Phase1, Phase2, Recruiting

A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

for
KRAS-mutant Non-small Cell Lung Cancer (NSCLC),
Location: Boston MA, Philadelphia PA, Fairfax VA, Tampa FL,
Sponsor: Kestrel Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07458347

Phase1, Recruiting

Identification and Validation of Blood-Based Biomarkers for Early Detection of Asymptomatic Lung Cancer in High-Risk Heavy Smokers

for
Lung Cancers
Location: Oklahoma City OK
Sponsor: Everest Detection, Inc.

Sex: All

Age: 30 - 70+

Code: NCT06816121

Recruiting

LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI)

for
Lung Cancer Screening
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 50 - 70+

Code: NCT07408531

Recruiting

Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)

for
Breast Cancer, Lung Cancer, Melanoma, Gynecologic Cancer,
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT07524114

Recruiting

Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors

for
Solid Tumor, Small Cell Lung Cancer (SCLC),
Location: Fort Worth TX, West Valley City UT, Los Angeles CA
Sponsor: Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT07517198

Phase1, Recruiting