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Study of Aerosolized Antibiotics and Pembrolizumab in Advanced Non-small Cell Lung Cancer

for
Advanced Non Small Cell Lung Cancer
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT05777603

Phase1, Recruiting

Genomic Investigation of Unusual Responders

for
Cancer, Breast Cancer, Non-small Cell Lung Cancer,
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT03740503

Recruiting

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Portland ME, Scarborough ME, Sanford ME, Stony Brook NY,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT06500455

Phase3, Recruiting

Multimodal Prehabilitation for Lung Cancer Surgery

for
Lung Cancer, Surgery
Location: Montreal
Sponsor: Stéphanie Chevalier

Sex: All

Age: 45+

Code: NCT05955248

Recruiting

Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and in Patients With Other Advanced Solid Tumors

for
Advanced HR+/HER2- Breast Cancer,
Location: Boston MA, New York NY, Montreal, Toronto,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18 - 70+

Code: NCT06726148

Phase1, Phase2, Recruiting

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APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

for
Solid Tumors, Advanced Cancer, Renal Cancer, Gastric Cancer,
Location: Montreal, Hershey PA, Chapel Hill NC, Toronto,
Sponsor: Apollomics Inc.

Sex: All

Age: 18+

Code: NCT03175224

Phase2, Recruiting

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

for
Advanced Non-Small Cell Lung Cancer,
Location: South Weymouth MA, Boston MA, Brighton MA,
Sponsor: Mirati Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT04613596

Phase2, Phase3, Recruiting

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

for
Locally Advanced Lung Non-Small Cell Carcinoma,
Location: Portland ME, Scarborough ME, South Portland ME,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT05624996

Phase3, Recruiting

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

for
Recurrent Lung Non-Small Cell Carcinoma,
Location: Brewer ME, Westerly RI, Manchester NH, Worcester MA,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT05642572

Phase2, Recruiting

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

for
Invasive Ductal Breast Carcinoma,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05837767

Recruiting

Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer

for
Locally Advanced Lung Non-Small Cell Carcinoma,
Location: Columbus OH, Duarte CA
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT05136846

Phase1, Recruiting

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

for
Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung,
Location: Fairhaven MA, Portland ME, Scarborough ME,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT06758401

Phase3, Recruiting

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

for
Advanced Lung Cancer
Location: New York NY, Hackensack NJ, Belleville NJ, Fairfax VA,
Sponsor: BioNTech SE

Sex: All

Age: 18+

Code: NCT06892548

Phase1, Phase2, Recruiting

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

for
Advanced Lung Non-Small Cell Carcinoma,
Location: Brewer ME, South Weymouth MA, Boston MA, Brighton MA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 70+

Code: NCT06096844

Phase3, Recruiting

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

for
Metastatic Lung Small Cell Carcinoma,
Location: Quebec, Camden NJ, Easton MD, Wilkes-Barre PA,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT04804644

Phase3, Recruiting

Chiauranib for Advanced Solid Malignant Tumors and Relapsed/Refractory SCLC.

for
Small Cell Lung Cancer, Advanced Solid Malignant Tumor
Location: Boston MA, Fairfax VA, Canton OH, Detroit MI,
Sponsor: Chipscreen Biosciences, Ltd.

Sex: All

Age: 18+

Code: NCT05271292

Phase1, Phase2, Recruiting

Phase 2 Study of Fingolimod in Lung Cancers

for
Non Small Cell Lung Cancer, Small-cell Lung Cancer
Location: Charleston SC
Sponsor: Medical University of South Carolina

Sex: All

Age: 18+

Code: NCT06424067

Phase2, Recruiting

Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

for
Advanced Cancer, Anal Carcinoma, Anal Cancer, Biliary Cancer,
Location: New Brunswick NJ
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT02628067

Phase2, Recruiting

Thoracic Specimen Registry

for
Thoracic Diseases, Lung Cancer, Lung Transplant
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT04118660

Recruiting

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

for
Advanced Lung Non-Squamous Non-Small Cell Carcinoma,
Location: Worcester MA, Waterford CT, Guilford CT, Glastonbury CT,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT04181060

Phase3, Recruiting