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Vaccine Responses in Patients With B Cell Malignancies

for
Lymphoma
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 18 - 70+

Code: NCT05170399

Recruiting

Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA With High Risk T-Cell ALL & Lymphoma

for
T-cell Acute Lymphoblastic Leukemia,
Location: Boston MA, Vallhala NY, Philadelphia PA, Gainsville FL,
Sponsor: New York Medical College

Sex: All

Age: 0 - 39

Code: NCT04972942

Phase1, Recruiting

Umbilical Cord Blood Transplantation From Unrelated Donors

for
Acute Leukemia, Immune Deficiency Disorder,
Location: Rochester NY
Sponsor: University of Rochester

Sex: All

Age: 0 - 70+

Code: NCT03016806

Recruiting

Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)

for
Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors
Location: Montreal, Ottawa, Kingston, Toronto, London, Regina,
Sponsor: Canadian Cancer Trials Group

Sex: All

Age: 18+

Code: NCT03297606

Phase2, Recruiting

Autologous HuCART19 T Cells Manufactured Using the CliniMACS Prodigy Platform for Pediatric B-ALL (huCART19 Prodigy)

for
B Cell Acute Lymphoblastic Leukemia (B-ALL),
Location: Philadelphia PA
Sponsor: Stephan Grupp MD PhD

Sex: All

Age: 0 - 29

Code: NCT05480449

Phase1, Phase2, Recruiting

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Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

for
Relapsed Classic Hodgkin Lymphoma
Location: Boston MA, Hackensack NJ, Nashville TN, Chicago IL,
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT04561206

Phase2, Recruiting

Loncastuximab Tesirine and Rituximab Following Stereotactic Radiosurgery in Patients With Central Nervous System Lymphomas (SOLAR)

for
Central Nervous System Lymphoma
Location: Providence RI, Philadelphia PA, Salt Lake City UT
Sponsor: University of Utah

Sex: All

Age: 18+

Code: NCT06607549

Phase1, Recruiting

Brentuximab Vedotin in Early Stage Hodgkin Lymphoma

for
Hodgkin Lymphoma
Location: Halifax, Saint John, New York NY, Ottawa, Miami FL,
Sponsor: University College, London

Sex: All

Age: 16 - 69

Code: NCT04685616

Phase3, Recruiting

A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma

for
Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06736613

Phase2, Recruiting

A Study Evaluating APG-115 as a Single Agent or in Combination With APG-2575 in Subjects With R/R T-PLL and NHL

for
T-Prolymphocytic Leukemia, Non-Hodgkins Lymphoma
Location: Houston TX
Sponsor: Ascentage Pharma Group Inc.

Sex: All

Age: 18+

Code: NCT04496349

Phase2, Recruiting

Integrated Molecular and Clinical Profiling to Improve Disease Characterization and Outcome Prediction in Nodal Marginal Zone Lymphoma

for
Nodal Marginal Zone Lymphoma
Location: New York NY, Miami FL, Toronto, Columbus OH,
Sponsor: International Extranodal Lymphoma Study Group (IELSG)

Sex: All

Age: 18+

Code: NCT05700149

Recruiting

Epcoritamab Plus Ibrutinib for the Treatment of Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphoma

for
Recurrent Diffuse Large B-Cell Lymphoma,
Location: Richmond VA, Columbus OH, Minneapolis MN
Sponsor: Yazeed Sawalha

Sex: All

Age: 18+

Code: NCT06536049

Phase1, Phase2, Recruiting

Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer

for
HIV, Kaposi's Sarcoma, Lymphomas,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT00006518

Recruiting

A Phase II Study of Loncastuximab Tesirine as Consolidation Strategy in Patients With LBCL in PR After CAR T-cell Therapy

for
Large B-cell Lymphoma, Lymphoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05464719

Phase2, Recruiting

A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

for
Advanced Solid Tumor, Refractory Non-Hodgkin Lymphoma
Location: Port Saint Lucie FL, Huntersville NC, Greenville SC,
Sponsor: FBD Biologics Limited

Sex: All

Age: 18+

Code: NCT05892718

Phase1, Recruiting

Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell Lymphoma

for
Mantle Cell Lymphoma
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT06572618

Phase2, Recruiting

A Study of Glofitamab-based Treatment in People With Diffuse Large B-cell Lymphoma

for
Diffuse Large B Cell Lymphoma (DLBCL),
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 65 - 70+

Code: NCT06765317

Phase2, Recruiting

Acalabrutinib Maintenance for the Treatment of Patients With Large B-cell Lymphoma

for
Diffuse Large B-Cell Lymphoma, High-grade B-cell Lymphoma,
Location: Los Angeles CA, Sacramento CA
Sponsor: Jonsson Comprehensive Cancer Center

Sex: All

Age: 18 - 70

Code: NCT05256641

Phase1, Phase2, Recruiting

Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

for
T-cell Acute Lymphoblastic Leukemia, T-cell Lymphoma,
Location: Charlotte NC, Memphis TN, Tulsa OK, San Diego CA
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 1 - 18

Code: NCT06390319

Phase2, Recruiting

A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)

for
Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia,
Location: New York NY, Philadelphia PA, San Antonio TX,
Sponsor: Autolus Limited

Sex: All

Age: 0 - 18

Code: NCT06173518

Phase1, Recruiting