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The Role of mGluR5 in CBT-I

for
Major Depressive Disorder (MDD)
Location: Stony Brook NY
Sponsor: Stony Brook University

Sex: All

Age: 18+

Code: NCT07076342

Recruiting

PET Imaging Using the Tracer [18F]VAT to Assess the Antidepressant Effect of Nicotine.

for
Major Depressive Disorder (MDD)
Location: Stony Brook NY
Sponsor: Stony Brook University

Sex: All

Age: 18 - 65

Code: NCT07095205

Recruiting

Accelerated TMS for Perinatal Depression

for
Perinatal Depression, Post Partum Depression,
Location: Boston MA
Sponsor: Brigham and Women's Hospital

Sex: Female

Age: 18 - 55

Code: NCT06968390

Recruiting

Feasibility and Acceptability of an E-learning Dialectical Behavior Therapy Skills Course

for
Depression - Major Depressive Disorder, Anxiety, Depression,
Location: Windsor
Sponsor: University of Windsor

Sex: All

Age: 18+

Code: NCT07088939

Recruiting

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

for
Healthy Volunteer, Major Depressive Disorder, Depression
Location: Bethesda MD
Sponsor: National Institute of Mental Health (NIMH)

Sex: All

Age: 18 - 65

Code: NCT03065335

Phase1, Recruiting

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NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for
Major Depressive Disorder
Location: Cedarhurst NY, New York NY, Verdun, Miami FL,
Sponsor: Neurocrine Biosciences

Sex: All

Age: 18+

Code: NCT06963021

Phase3, Recruiting

Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits

for
Major Depressive Disorder (MDD), Cognitive Dysfunction
Location: Portland OR
Sponsor: Portland VA Medical Center

Sex: All

Age: 18+

Code: NCT06728774

Recruiting

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

for
Major Depressive Disorder, Suicidal Ideas, Suicide, Attempted,
Location: Huntsville AL, Birmingham AL
Sponsor: University of Alabama at Birmingham

Sex: All

Age: 10 - 24

Code: NCT05437588

Recruiting

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

for
Major Depressive Disorder (MDD),
Location: Russells Mills MA, Boston MA, Cromwell CT,
Sponsor: Seaport Therapeutics

Sex: All

Age: 18 - 65

Code: NCT07065240

Phase2, Recruiting

Theta-Burst Stimulation to Treat Depression

for
Major Depressive Disorder (MDD)
Location: Toronto
Sponsor: Centre for Addiction and Mental Health

Sex: All

Age: 18 - 50

Code: NCT07033780

Phase1, Recruiting

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

for
Major Depressive Disorder
Location: Boston MA, Watertown MA, Methuen MA, Worcester MA,
Sponsor: Xenon Pharmaceuticals Inc.

Sex: All

Age: 18 - 70+

Code: NCT07076407

Phase3, Recruiting

Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking

for
Stroke, Depression - Major Depressive Disorder,
Location: Durham NC, Charleston SC
Sponsor: Medical University of South Carolina

Sex: All

Age: 21+

Code: NCT07050355

Recruiting

Neutralizing Interleukin (IL)-6

for
Major Depressive Disorder
Location: New York NY
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All

Age: 18 - 70

Code: NCT07493317

Phase2, Recruiting

Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains

for
Depression - Major Depressive Disorder
Location: Mason OH
Sponsor: University of Cincinnati

Sex: All

Age: 18 - 60

Code: NCT06795451

Phase1, Phase2, Recruiting

A Randomized Neuroimaging Trial of Psilocybin in Depression

for
Depressive Disorder, Major Depressive Disorder
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18 - 64

Code: NCT06072898

Phase2, Recruiting

Decoding and Modulating Affective Brain States

for
Rumination, Major Depressive Disorder, Anxiety
Location: Philadelphia PA
Sponsor: University of Pennsylvania

Sex: All

Age: 18 - 65

Code: NCT05437705

Recruiting

Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression

for
Major Depressive Disorder
Location: Chapel Hill NC
Sponsor: University of North Carolina, Chapel Hill

Sex: Female

Age: 18 - 45

Code: NCT06610305

Recruiting

Interleaved TMS-fMRI in Ultra-treatment Resistant Depression

for
Major Depressive Disorder
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 20 - 65

Code: NCT05813093

Recruiting

DBS for Depression

for
Major Depressive Disorder
Location: Dallas TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 22 - 70

Code: NCT03437928

Recruiting

5-HTP and Creatine for Depression R33 Phase

for
Major Depressive Disorder
Location: Salt Lake City UT
Sponsor: University of Utah

Sex: All

Age: 18 - 65

Code: NCT05895747

Phase2, Recruiting