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Optimizing Brain Excitability in Depression

for
Major Depressive Disorder
Location: Iowa City CA, Stanford CA
Sponsor: Stanford University

Sex: All

Age: 18 - 65

Code: NCT07242105

Recruiting

ACT_for Alcohol Use Disorder and Depression

for
Depression - Major Depressive Disorder, Alcohol Use Disorder
Location: Montreal
Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All

Age: 18 - 70

Code: NCT06620276

Recruiting

Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans

for
Major Depressive Disorder, Epilepsy
Location: Stanford CA
Sponsor: Stanford University

Sex: All

Age: 18 - 65

Code: NCT05996900

Recruiting

Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

for
Major Depressive Disorder, Apathy
Location: Orlando FL
Sponsor: AdventHealth

Sex: All

Age: 60+

Code: NCT05877885

Recruiting

Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation

for
Major Depressive Disorder (MDD), Suicidal Ideation,
Location: Cincinnati OH
Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All

Age: 14 - 18

Code: NCT07217444

Recruiting

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Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study

for
Treatment Resistant Depression (TRD),
Location: San Diego CA
Sponsor: University of California, San Diego

Sex: All

Age: 18 - 70+

Code: NCT07217223

Recruiting

A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for
Major Depressive Disorder
Location: Sherbrooke, Glen Oaks NY, Kingston, Miami Gardens FL,
Sponsor: Neurocrine Biosciences

Sex: All

Age: 18+

Code: NCT07196501

Phase3, Recruiting

The Effect of PROSE or Scleral Lenses on Mental Health

for
Depression - Major Depressive Disorder
Location: Needham MA
Sponsor: Boston Sight

Sex: All

Age: 0+

Code: NCT07195721

Recruiting

Stress Dynamics and Familial Risk for Depression in Female Adolescents

for
Major Depressive Disorder
Location: Belmont MA
Sponsor: Mclean Hospital

Sex: Female

Age: 13 - 15

Code: NCT06816329

Recruiting

Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial

for
Suicide Risk, Major Depressive Disorder (MDD)
Location: The Bronx NY
Sponsor: Marianne Goodman

Sex: All

Age: 18 - 70

Code: NCT06854224

Phase2, Recruiting

Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression

for
Depression - Major Depressive Disorder,
Location: Stanford CA
Sponsor: Stanford University

Sex: All

Age: 65+

Code: NCT07188623

Recruiting

A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

for
Schizophrenia, Schizoaffective Disorder, Bipolar Disorder,
Location: Richmond VA, Miami FL, Hialeah FL, Orange City FL,
Sponsor: Neurocrine Biosciences

Sex: All

Age: 18+

Code: NCT07105111

Recruiting

JAK Signaling in Depression

for
Major Depressive Disorder
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 25 - 55

Code: NCT07003997

Phase2, Recruiting

Enhancing Slow Wave Sleep in Depression

for
Depression - Major Depressive Disorder
Location: Winston-Salem NC
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 40 - 70+

Code: NCT07143838

Recruiting

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

for
Major Depressive Episode (MDE), Major Depressive Disorder (MDD),
Location: Orlando FL, New Orleans LA
Sponsor: Tonix Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT07621237

Phase2, Recruiting

Digital Intervention for Physical Activity

for
Depression - Major Depressive Disorder, Anxiety, Stress
Location: Auburn AL
Sponsor: Auburn University

Sex: All

Age: 19 - 40

Code: NCT07130734

Recruiting

Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments

for
Depression, Major Depressive Disorder
Location: Pittsburgh PA
Sponsor: Marta Peciña, MD PhD

Sex: All

Age: 18 - 55

Code: NCT06976840

Recruiting

Mechanisms Of Orbitofrontal Stimulation in Depression

for
Major Depressive Disorder (MDD)
Location: Boston MA
Sponsor: Subha Subramanian

Sex: All

Age: 18 - 65

Code: NCT07230990

Recruiting

Psilocybin to Treat Depression in Spinal Cord Injury

for
Spinal Cord Injury, Depression - Major Depressive Disorder,
Location: The Bronx NY
Sponsor: James J. Peters Veterans Affairs Medical Center

Sex: All

Age: 22+

Code: NCT07251491

Phase1, Phase2, Recruiting

Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

for
Major Depressive Disorder (MDD)
Location: Philadelphia PA
Sponsor: University of Pennsylvania

Sex: All

Age: 25 - 65

Code: NCT06788249

Early_phase1, Recruiting