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Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

for
Solid Tumor, Adult, Metastatic Solid Tumor, Refractory Cancer,
Location: Fairfax VA, Canton OH, Detroit MI, St Louis MO
Sponsor: Sairopa B.V.

Sex: All

Age: 18+

Code: NCT05856981

Phase1, Recruiting

Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations

for
Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma,
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18 - 70+

Code: NCT03786796

Phase2, Recruiting

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

for
High Grade Epithelial Ovarian Cancer,
Location: Boston MA, Providence RI, Camden NJ, Doylestown PA,
Sponsor: Genmab

Sex: All

Age: 18+

Code: NCT05579366

Phase1, Phase2, Recruiting

Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

for
Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation,
Location: Baltimore MD, Winston-Salem NC, Columbus OH,
Sponsor: National Cancer Institute (NCI)

Sex: Male

Age: 18+

Code: NCT05691465

Phase2, Recruiting

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

for
Cervical Cancer, Throat Cancer, Oropharynx Cancer, Anal Cancer,
Location: New Brunswick NJ, Bethesda MD
Sponsor: Christian Hinrichs

Sex: All

Age: 18+

Code: NCT05686226

Phase2, Recruiting

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A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

for
Solid Tumor, Advanced Solid Tumor, Solid Tumor, Adult,
Location: Boston MA, Hackensack NJ, Philadelphia PA, Fairfax VA,
Sponsor: NiKang Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06586957

Phase1, Recruiting

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

for
Solid Tumours, Sarcoma, HNSCC, Non Small Cell Lung Cancer,
Location: Houston TX, Beverly Hills CA, Santa Monica CA
Sponsor: Epkin

Sex: All

Age: 18+

Code: NCT06789172

Phase1, Recruiting

A Study of Abemaciclib and Cabozantinib in People With Clear Cell Renal Cell Carcinoma (ccRCC)

for
Metastatic Renal Cell Carcinoma,
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06835972

Phase1, Phase2, Recruiting

Trial of an Alternative Cabozantinib Dosing Schedule in Metastatic Renal Cell Carcinoma and Neuroendocrine Tumors

for
Metastatic Renal Cell Carcinoma,
Location: Philadelphia PA
Sponsor: Fox Chase Cancer Center

Sex: All

Age: 18+

Code: NCT05263050

Phase2, Recruiting

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

for
Anatomic Stage III Breast Cancer AJCC v8,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 16+

Code: NCT05269381

Phase1, Phase2, Recruiting

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

for
Advanced Endometrial Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05039801

Phase1, Recruiting

Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT05098210

Phase1, Recruiting

Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Cancer of Variant Histology

for
Bladder Squamous Cell Carcinoma,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT05756569

Phase2, Recruiting

Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

for
Advanced Ovarian Carcinoma,
Location: Boston MA, Mineola NY, New York NY, Bethlehem PA,
Sponsor: M.D. Anderson Cancer Center

Sex: Female

Age: 18+

Code: NCT04575935

Phase3, Recruiting

A Beta-only IL-2 ImmunoTherapY Study

for
Advanced Solid Tumor, Unresectable Solid Tumor,
Location: Boca Raton FL, Toronto, Detroit MI, Atlanta GA,
Sponsor: Medicenna Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05086692

Phase1, Phase2, Recruiting

Genetic Testing to Select Therapy for the Treatment of Advanced or Metastatic Kidney Cancer, OPTIC RCC Study

for
Advanced Clear Cell Renal Cell Carcinoma,
Location: Cleveland OH, Nashville TN, Dallas TX, Duarte CA,
Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All

Age: 18+

Code: NCT05361720

Phase2, Recruiting

Folate Receptor Alpha Dendritic Cells (FRαDCs) or Placebo for the Treatment of Patients With Stage III or IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer, FAROUT Trial

for
Advanced Fallopian Tube Carcinoma,
Location: Jacksonville FL, Rochester MN, Scottsdale AZ
Sponsor: Mayo Clinic

Sex: Female

Age: 18+

Code: NCT06639074

Phase2, Recruiting

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

for
Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma,
Location: Jacksonville FL, Grand Forks ND
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05969860

Phase2, Recruiting

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

for
Advanced Breast Carcinoma, Advanced Endometrial Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05092373

Phase1, Recruiting

Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors

for
Metastatic Chondrosarcoma, Locally Advanced Chondrosarcoma,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06176989

Phase2, Recruiting