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Teclistamab in Combination With Daratumumab for High-Risk Smoldering Myeloma: A Clinical and Correlative Phase 2 Immuno-Oncology Study (the REVIVE Study)

for
Multiple Myeloma
Location: Miami FL
Sponsor: Carl Ola Landgren, MD, PhD

Sex: All

Age: 18+

Code: NCT06100237

Phase2, Recruiting
Active & Responsive

Microelectrode Recordings From the Vagus Nerve in Awake Humans

for
Epilepsy
Location: Minneapolis MN
Sponsor: University of Minnesota

Sex: All

Age: 18 - 40

Code: NCT06016686

Phase1, Recruiting
Featured

A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations

for
Multiple Myeloma
Location: New York NY, Chapel Hill NC, Winston-Salem NC,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT06892522

Phase1, Phase2, Recruiting

Iberdomide, Daratumumab, Carfilzomib, and Dexamethasone (Iber-KDd) in Patients With Relapsed/Refractory Multiple Myeloma

for
Refractory Multiple Myeloma, Relapsed Multiple Myeloma
Location: Miami FL
Sponsor: Benjamin T Diamond, MD

Sex: All

Age: 18 - 70+

Code: NCT05896228

Phase2, Recruiting
Featured

Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma

for
Multiple Myeloma
Location: New York NY, New Brunswick NJ, Montreal,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT06896916

Phase1, Recruiting

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Featured

A Study to Evaluate Adverse Events, Change in Disease Activity, Tolerability, and How Intravenous ABBV-438 Moves Through the Body in Adult Participants With Multiple Myeloma (MM)

for
Multiple Myeloma
Location: Tampa FL, Newnan GA, Grand Rapids MI, Denver CO,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT07409246

Phase1, Recruiting

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

for
Coronavirus Infection (COVID-19),
Location: Montreal, Durham NC, Cincinnati OH, Austin TX,
Sponsor: Duke University

Sex: All

Age: 0 - 20

Code: NCT04278404

Recruiting

Beta Glucan's Effect on Pembrolizumab Immunologic Response in Stage III-IV Melanoma

for
Melanoma Stage III, Melanoma Stage IV
Location: Louisville KY
Sponsor: Kelly McMasters

Sex: All

Age: 18+

Code: NCT04513028

Recruiting

Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function

for
Traumatic Brain Injury, Stroke, Brain Disease,
Location: Pittsburgh PA
Sponsor: Jorge Gonzalez-Martinez

Sex: All

Age: 18 - 70+

Code: NCT07056348

Recruiting

Q702 for the Treatment of Patients With Hematologic Malignancies

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Rochester MN, Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06712810

Phase1, Recruiting

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

for
Diffuse Midline Glioma, H3 K27-Altered,
Location: Boston MA, Valhalla NY, New York NY, Philadelphia PA,
Sponsor: Children's Oncology Group

Sex: All

Age: 1 - 21

Code: NCT04870944

Phase1, Phase2, Recruiting

Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot Study

for
Solid Tumor Malignancies, Brain Metastasases,
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18+

Code: NCT07476781

Recruiting

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

for
Recurrent Glioblastoma,
Location: Bethesda MD
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All

Age: 18 - 70+

Code: NCT07416188

Phase1, Phase2, Recruiting

Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).

for
Diffuse Intrinsic Pontine Glioma, DIPG, Brain Tumor, CNS Tumor,
Location: Seattle WA
Sponsor: BrainChild Bio, Inc

Sex: All

Age: 1 - 26

Code: NCT07680439

Phase2, Recruiting

Lymphatic Anomalies Registry for the Assessment of Outcome Data

for
Lymphatic Malformation, Generalized Lymphatic Anomaly (GLA),
Location: Boston MA
Sponsor: Boston Children's Hospital

Sex: All

Age: 0+

Code: NCT02399527

Recruiting

Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy

for
Breast Carcinoma, Esophageal Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT00991094

Recruiting

Cancer Genetic Testing in Ethnic Populations

for
Breast Carcinoma, Carcinoma of Unknown Primary,
Location: Jacksonville FL, Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT04475640

Recruiting

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04771520

Phase2, Recruiting

Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)

for
Spinal Cord Injuries, Spinal Cord Diseases,
Location: West Orange NJ
Sponsor: Kessler Foundation

Sex: All

Age: 18 - 70+

Code: NCT05731986

Recruiting

Lentiviral Gene Therapy (Zamtocabtagene Autoleucel) LTFU

for
Non Hodgkin Lymphoma,
Location: Boston MA, New Haven CT, Durham NC, Chicago IL,
Sponsor: Miltenyi Biomedicine GmbH

Sex: All

Age: 18+

Code: NCT06116110

Recruiting