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Leflunomide in Combination With Decitabine for Treatment of Relapsed or Refractory Myelodysplastic Syndromes

for
Myelodysplastic Syndromes
Location: Morgantown WV
Sponsor: West Virginia University

Sex: All

Age: 18+

Code: NCT06923488

Phase1, Phase2, Recruiting

Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants

for
Germline Mutation, Myelodysplastic Syndromes,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 0 - 70+

Code: NCT07019155

Recruiting

Collection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples From Healthy Volunteers Used for Comparative Analysis of Myeloid Malignancies

for
Myelodysplastic Syndromes
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT05588154

Recruiting

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

for
Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS),
Location: Boston MA, New York NY, Chapel Hill NC, Columbus OH,
Sponsor: Institut de Recherches Internationales Servier

Sex: All

Age: 18+

Code: NCT06465953

Phase3, Recruiting

A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

for
AML (Acute Myelogenous Leukemia), Acute Lymphoid Leukemia (ALL),
Location: Boston MA, New York NY, Charlottesville VA,
Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All

Age: 18 - 66

Code: NCT06859424

Phase2, Recruiting

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Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse

for
Acute Myeloid Leukemia, Acute Undifferentiated Leukemia,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT06928662

Phase1, Phase2, Recruiting

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

for
B-Cell Lymphoma, Myelodysplastic Syndromes (MDS),
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 12 - 70+

Code: NCT05092451

Phase1, Phase2, Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Renal Impairment

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Location: Houston TX
Sponsor: Taiho Oncology, Inc.

Sex: All

Age: 18+

Code: NCT04953897

Phase1, Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Hepatic Impairment

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Location: Houston TX
Sponsor: Taiho Oncology, Inc.

Sex: All

Age: 18+

Code: NCT04953910

Phase1, Recruiting

A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for
Myelodysplastic Syndrome, Anemia
Location: Tamarac FL, Atlanta GA, Nashville TN, Skokie IL,
Sponsor: Takeda

Sex: All

Age: 18+

Code: NCT07422480

Phase3, Recruiting

ICP-248 in Combination With Azacitidine for the Treatment in Patients With Myeloid Malignancies

for
Acute Myelogenous Leukemia, Myelodysplastic Syndromes (MDS)
Location: New Haven CT, New York NY, Chapel Hill NC, Tampa FL,
Sponsor: Beijing InnoCare Pharma Tech Co., Ltd.

Sex: All

Age: 18+

Code: NCT06656494

Phase1, Recruiting

Iadademstat With Hypomethylating Agent in Patients With Myelodysplastic Syndrome

for
Myelodysplastic Syndromes
Location: Milwaukee WI
Sponsor: Medical College of Wisconsin

Sex: All

Age: 18+

Code: NCT06502145

Phase1, Recruiting

Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation

for
Acute Myeloid Leukemia, Leukemia, Leukemia, Myeloid,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT06138587

Phase1, Recruiting

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

for
Acute Myeloid Leukemia, Essential Thrombocythemia,
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 18+

Code: NCT04282187

Phase2, Recruiting

Collection of Samples From Patients With MDS

for
Myelodysplastic Syndromes(MDS)
Location: La Jolla CA, Irvine CA
Sponsor: PersImmune, Inc

Sex: All

Age: 18+

Code: NCT03072498

Recruiting

Collection of Tissue Samples for Cancer Research

for
Neoplasms, Lymphomas, Multiple Myeloma,
Location: Baltimore MD, Bethesda MD, Buffalo NY, Pittsburgh PA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 0+

Code: NCT00900198

Recruiting

A Telehealth Advance Care Planning Intervention

for
Myeloid Malignancy, Acute Myeloid Leukemia,
Location: Rochester NY
Sponsor: University of Rochester

Sex: All

Age: 60+

Code: NCT05875805

Recruiting

Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies

for
Haematological Malignancy, Acute Myeloid Leukemia,
Location: Philadelphia PA, Bethesda MD, Atlanta GA,
Sponsor: CellCentric Ltd.

Sex: All

Age: 18+

Code: NCT04068597

Phase1, Phase2, Recruiting

Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors

for
Lymphoblastic Leukemia, Cancer Survivors, Aplastic Anemia,
Location: Philadelphia PA, Memphis TN, Duarte CA
Sponsor: Children's Hospital of Philadelphia

Sex: All

Age: 10 - 30

Code: NCT05194397

Phase2, Recruiting

Allo HSCT Using RIC and PTCy for Hematological Diseases

for
Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 0 - 70+

Code: NCT05805605

Phase2, Recruiting