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Cord Blood Transplant in Adults With Blood Cancers

for
Acute Myelogenous Leukemia (AML),
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 21 - 65

Code: NCT05884333

Phase2, Recruiting

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

for
Acute Leukemia, Acute Lymphoblastic Leukemia,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 0+

Code: NCT04195633

Phase2, Recruiting

MDS-CAN: A Prospective National MDS Clinical Database and Local Tissue Bank

for
Myelodysplastic Syndrome (MDS)
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 19+

Code: NCT02537990

Recruiting

Investigation of the Genetics of Hematologic Diseases

for
Bone Marrow Failure Syndromes, Erythrocyte Disorder,
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0+

Code: NCT02720679

Recruiting

SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

for
Acute Myeloid Leukemia, Myelodysplastic Syndrome,
Location: Boston MA, Houston TX, Duarte CA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT03113643

Phase1, Recruiting

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Effects of Antithymocyte Globulin in Adults With Myelodysplastic Syndrome

for
Myelodysplastic Syndrome
Location: Hershey PA, Tampa FL, Cleveland OH
Sponsor: Office of Rare Diseases (ORD)

Sex: All

Age: 18+

Code: NCT00466843

Phase2, Recruiting

A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes

for
Higher-risk Myelodysplastic Syndromes
Location: New Haven CT, Bronx NY, Columbia MD, Bethesda MD,
Sponsor: Akeso

Sex: All

Age: 18+

Code: NCT06196203

Phase2, Recruiting

CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

for
Acute Myeloid Leukemia With Gene Mutations,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04493164

Phase2, Recruiting

Venetoclax Plus Intensive Chemotherapy in AML and Advanced MDS

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Location: The Bronx NY
Sponsor: Montefiore Medical Center

Sex: All

Age: 18 - 70+

Code: NCT05342584

Phase1, Recruiting

A Study of CTX-712 in Relapsed/Refractory Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndromes

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Location: Charlottesville VA, Rochester NY, Jacksonville FL,
Sponsor: Chordia Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05732103

Phase1, Phase2, Recruiting

Study of R289 in Patients With Lower-risk Myelodysplastic Syndromes (LR MDS)

for
Low Risk Myelodysplastic Syndromes
Location: New York NY, Hackensack NJ, Durham NC, Miami FL,
Sponsor: Rigel Pharmaceuticals

Sex: All

Age: 18+

Code: NCT05308264

Phase1, Phase2, Recruiting

Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell Transplant

for
Acute Leukemia, Myelodysplastic Syndrome,
Location: Birmingham AL
Sponsor: University of Alabama at Birmingham

Sex: All

Age: 18 - 70+

Code: NCT06265584

Phase2, Recruiting

A Phase Ib Study of Rezatapopt in Combination With Azacitidine in Patients With TP53Y220C Mutant Myeloid Malignancies (Acute Myeloid Leukemia or Myelodysplastic Syndrome)

for
Myelodysplastic Syndrome, Acute Myeloid Leukemia
Location: Tampa FL, Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06616636

Phase1, Recruiting

BXCL701 Phase 1 R/R Acute Myeloid Leukemia or Myelodysplastic Syndrome

for
Acute Myeloid Leukemia,
Location: Boston MA
Sponsor: Eric Stephen Winer, MD

Sex: All

Age: 18+

Code: NCT05703542

Phase1, Recruiting

A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.

for
Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia,
Location: Miami FL, Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06566742

Phase2, Recruiting

Umbilical Cord Blood Transplantation From Unrelated Donors

for
Acute Leukemia, Immune Deficiency Disorder,
Location: Rochester NY
Sponsor: University of Rochester

Sex: All

Age: 0 - 70+

Code: NCT03016806

Recruiting

Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes,
Location: Rochester NY
Sponsor: Omar Aljitawi

Sex: All

Age: 18 - 70+

Code: NCT03964506

Early_phase1, Recruiting

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)

for
Myelodysplastic Syndromes, Cytopenia
Location: Shirley NY, Hackensack NJ, Bethesda MD, Miami FL,
Sponsor: Takeda

Sex: All

Age: 18+

Code: NCT04419649

Phase2, Recruiting

Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

for
Acute Myeloid Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04047641

Phase1, Phase2, Recruiting

Revisiting the Universal Donor: Does Exposure to O Blood Products Affect Patient Outcomes?

for
Myelodysplastic Syndrome
Location: Hamilton
Sponsor: McMaster University

Sex: All

Age: 18 - 70+

Code: NCT04859218

Recruiting