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A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

for
Non-Small Cell Lung Cancer
Location: Fairfax VA, Atlanta GA, Santa Monica CA
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07098338

Phase2, Recruiting

Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

for
Non-small Cell Lung Cancer (NSCLC)
Location: Halifax, Moncton, South Portland ME, Boston MA,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07291037

Phase3, Recruiting

Clinical Trial of CD40L-Augmented TIL for Patients With EGFR, ALK, ROS1 or HER2-Driven NSCLC

for
Non Small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer,
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT05681780

Phase1, Recruiting

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

for
Non-small Cell Lung Cancer (NSCLC)
Location: Quebec, Westbury NY, New York NY, Montreal, Norfolk VA,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT07361497

Phase3, Recruiting

A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

for
Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer,
Location: Baltimore MD, Washington D.C. DC, Jacksonville FL,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07154290

Phase2, Recruiting

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A Phase 1/2 Study of TRI-611 in ALK-Positive NSCLC

for
ALK-positive NSCLC, ALK-Positive Lung Cancer,
Location: Boston MA, New York NY, Fairfax VA, Durham NC,
Sponsor: TRIANA Biomedicines, Inc.

Sex: All

Age: 18+

Code: NCT07491497

Phase1, Phase2, Recruiting

A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

for
KRAS-mutant Non-small Cell Lung Cancer (NSCLC),
Location: Boston MA, Philadelphia PA, Fairfax VA, Tampa FL,
Sponsor: Kestrel Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07458347

Phase1, Recruiting

Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors

for
Solid Tumor, Small Cell Lung Cancer (SCLC),
Location: Fort Worth TX, West Valley City UT, Los Angeles CA
Sponsor: Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT07517198

Phase1, Recruiting

DK222 Study at Hopkins

for
Non-Small Cell Lung Cancer, Urothelial Cancer
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT07140315

Phase1, Recruiting

A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types

for
Esophageal Squamous Cell Carcinoma,
Location: Lake Success NY, Fairfax VA, Sarasota FL, Detroit MI,
Sponsor: IDEAYA Biosciences

Sex: All

Age: 18+

Code: NCT07503808

Phase1, Recruiting

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

for
Non-Small Cell Lung Cancer (NSCLC)
Location: Westbury NY, New York NY, Lancaster PA, York PA,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT07361510

Phase3, Recruiting

Trial Investigating Visugromab and Nivolumab With or Without Docetaxel in 2L Treatment of Participants With Metastatic NSCLC

for
Metastatic Non-Squamous Non-Small Cell Lung Cancer,
Location: Mineola NY, New York NY, Durham NC, Birmingham AL,
Sponsor: CatalYm GmbH

Sex: All

Age: 18+

Code: NCT07246863

Phase2, Recruiting

Trial Investigating Visugromab in Combination With Immunochemotherapy in 1L Treatment of Participants With Metastatic NSCLC

for
Metastatic Non-Squamous Non-Small Cell Lung Cancer,
Location: New Haven CT, New York NY, Durham NC, Charleston SC,
Sponsor: CatalYm GmbH

Sex: All

Age: 18+

Code: NCT07098988

Phase2, Recruiting

A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer

for
Non-Small Cell Lung Cancer, Non-small Cell Lung Cancer Stage II,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07428044

Phase2, Recruiting

Post-operative Radiotherapy After Neodjuvant Chemo-immunotherapy and Surgery in Stage III NSCLC

for
Non Small Cell Lung Cancer, Stage III Lung Cancer
Location: Montreal
Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All

Age: 18+

Code: NCT06878274

Phase2, Recruiting

Study of Pembrolizumab and Single Agent Chemotherapy as First Line Treatment for Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer With Eastern Cooperative Oncology Group (ECOG) Performance Status of 2

for
Non-small Cell Lung Cancer
Location: Rochester NY
Sponsor: University of Rochester

Sex: All

Age: 18+

Code: NCT04297605

Phase1, Recruiting

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

for
Renal Cell Carcinoma (RCC),
Location: Boston MA, New Haven CT, New York NY, Hackensack NJ,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT05176483

Phase1, Recruiting

A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)

for
Squamous Non-small Cell Lung Cancer
Location: Paramus NJ, Albany NY, Fairfax VA, Tampa FL,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07221474

Phase2, Recruiting

Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

for
Seizures, Primary Motor Cortex,
Location: Boston MA
Sponsor: Ayal A. Aizer, MD

Sex: All

Age: 18+

Code: NCT07130786

Phase2, Recruiting

Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction

for
Brain Metastases, Adult, Brain Tumor - Metastatic,
Location: Boston MA
Sponsor: Ayal A. Aizer, MD

Sex: All

Age: 18+

Code: NCT07132190

Phase2, Recruiting