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EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer

for
Non Small Cell Lung Cancer
Location: Ann Arbor MI, Houston TX, San Diego CA
Sponsor: VA Office of Research and Development

Sex: All

Age: 18+

Code: NCT05467748

Phase1, Phase2, Recruiting

An External Control Arm Study in Non-Small Cell Lung Cancer

for
Non Small Cell Lung Cancer
Location: Milford DE, Dover DE, Elk Grove IL, Rolling Meadows IL,
Sponsor: N-Power Medicine

Sex: All

Age: 18+

Code: NCT07174388

Recruiting

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

for
Cancer, Immunotherapy, Advanced Solid Tumors Cancer,
Location: Frederick MD, St Louis MO, Springfield MO,
Sponsor: Elephas

Sex: All

Age: 18+

Code: NCT07327489

Recruiting

A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies

for
Advanced Solid Malignancies, Non-small Cell Lung Cancer (NSCLC),
Location: Baltimore MD, Fairfax VA, Toronto, San Antonio TX,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT07223047

Phase1, Phase2, Recruiting

Promoting Immunotherapy Efficacy With Low-Dose Liver RT

for
Low-Dose Liver Radiation (LD-LRT), Non Small Cell Lung Cancer,
Location: Cincinnati OH
Sponsor: Jordan Kharofa

Sex: All

Age: 18+

Code: NCT07225036

Recruiting

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A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

for
Colorectal Cancer, Pancreatic Cancer,
Location: Boston MA, Fairfax VA, San Antonio TX,
Sponsor: PAQ Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07300150

Phase1, Recruiting

Study of NXP900 With Osimertinib in Subjects With Advanced, EGFR-Mutated Non-Small Cell Lung Cancer

for
EGFR Mutation Positive Non-small Cell Lung Cancer,
Location: Calverton MD, Fairfax VA, Pittsburgh PA, Houston TX,
Sponsor: Nuvectis Pharma, Inc.

Sex: All

Age: 18+

Code: NCT07315113

Phase1, Recruiting

Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

for
Non-small Cell Lung Cancer
Location: Stony Brook NY, Lake Success NY, Rego Park NY,
Sponsor: Canadian Cancer Trials Group

Sex: All

Age: 18+

Code: NCT06686771

Phase3, Recruiting

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

for
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC),
Location: Boston MA, New Haven CT, New York NY, Baltimore MD,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT07349537

Phase1, Recruiting

A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease

for
NSCLC, NSCLC, Stage I, NSCLC Stage II,
Location: Commack NY, Uniondale NY, East White Plains NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07323732

Phase2, Recruiting

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

for
Head and Neck Squamous Cell Carcinoma HNSCC,
Location: Boston MA, New York NY, Washington D.C. DC, Fairfax VA,
Sponsor: Sutro Biopharma, Inc.

Sex: All

Age: 18+

Code: NCT07227168

Phase1, Recruiting

DRP-104 in Patients With NFE2L2/KEAP1-altered Non-Small Cell Lung Cancer

for
Non Small Cell Lung Cancer
Location: New York NY
Sponsor: NYU Langone Health

Sex: All

Age: 18+

Code: NCT07249372

Phase2, Recruiting

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

for
Non-Small Cell Lung Cancer
Location: Boston MA, Mineola NY, New York NY, Philadelphia PA,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT07100080

Phase2, Phase3, Recruiting

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

for
Renal Cell Carcinoma, Non Small Cell Lung Cancer, Melanoma,
Location: Pittsburgh PA
Sponsor: Diwakar Davar

Sex: All

Age: 18+

Code: NCT07223424

Phase2, Recruiting

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

for
Solid Tumor, Adult, Non-small Cell Lung Cancer, Melanoma
Location: New York NY, New Brunswick NJ, Morristown NJ,
Sponsor: Pierre Fabre Medicament

Sex: All

Age: 18+

Code: NCT04913285

Phase1, Recruiting

A Phase 2 Platform Study of Immunomodulatory Compounds in ICI-refractory Non-small Cell Lung Cancer

for
Non-Small Cell Lung Cancer, ICI-refractory
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT07133425

Phase2, Recruiting

Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations

for
Non-Small-Cell Lung Cancer,
Location: Lake Success NY, New York NY, Philadelphia PA, Ottawa,
Sponsor: ArriVent BioPharma, Inc.

Sex: All

Age: 18+

Code: NCT07185997

Phase3, Recruiting

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

for
Non-small Cell Lung Cancer
Location: Westbrook ME, Farmington CT, Stamford CT, Hackensack NJ,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07190248

Phase3, Recruiting

Dyadic Yoga Program for Patients Undergoing Thoracic Radiotherapy and Their Family Caregivers: The Testing of a Mobile Application Delivery

for
Non-Small Cell Lung Cancer
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06919874

Recruiting

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

for
Non-Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer,
Location: Philadelphia PA, Minneapolis MN, Houston TX,
Sponsor: Fate Therapeutics

Sex: All

Age: 18+

Code: NCT07216105

Phase1, Recruiting