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Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

for
Non-small Cell Lung Cancer
Location: Boston MA, New York NY, Fairfax VA, Orange City FL,
Sponsor: Boehringer Ingelheim

Sex: All

Age: 18+

Code: NCT07195695

Phase3, Recruiting

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

for
Non-small Cell Carcinoma, Non-Small Cell Lung Cancer Metastatic,
Location: Quebec, White Plains NY, The Bronx NY, Belleville NJ,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07144280

Phase3, Recruiting

Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

for
Advanced/Metastatic Non-Small Cell Lung Cancer,
Location: Neptune City NJ, The Bronx NY, Teaneck NJ,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07227298

Phase1, Phase2, Recruiting

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

for
Mesothelioma, Non Small Cell Lung Cancer,
Location: Brookline MA, Port Jefferson Station NY, Mineola NY,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT05245500

Phase1, Recruiting

RAPA-201 Therapy of Solid Tumors

for
Solid Tumor, Small Cell and Non-small Cell Lung Cancer,
Location: Hackensack NJ
Sponsor: Rapa Therapeutics LLC

Sex: All

Age: 18+

Code: NCT05144698

Phase1, Phase2, Recruiting

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Hyperthermia/Thermal Therapy With Chemotherapy to Treat Inoperable or Metastatic Tumors

for
Neuroendocrine Cancer, Small Cell Lung Cancer,
Location: Houston TX
Sponsor: The University of Texas Health Science Center, Houston

Sex: All

Age: 18+

Code: NCT00178698

Phase2, Recruiting

GI-101/GI-101A as a Single Agent or in Combination With Pembrolizumab or Lenvatinib in Advanced Solid Tumors

for
Advanced Solid Tumor, Metastatic Solid Tumor, Cervical Cancer,
Location: New York NY, Huntersville NC
Sponsor: GI Innovation, Inc.

Sex: All

Age: 18+

Code: NCT04977453

Phase1, Phase2, Recruiting

Beating Lung Cancer in Ohio Protocol in Improving Survival in Patients With Stage IV Non-Small Cell Lung Cancer

for
Cigarette Smoker, Current Smoker, Lung Adenocarcinoma,
Location: Columbus OH
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT03199651

Recruiting

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

for
Endocrine Tumors, Non-Small Cell Lung Cancer, Ovarian Cancer,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT03412877

Phase2, Recruiting

Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer

for
Lung Cancer, Lung Cancer Metastatic, Brain Metastases,
Location: Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT05452005

Phase1, Recruiting

Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC

for
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Location: Montreal, Baltimore MD, Fairfax VA, Houston TX,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT04686305

Phase1, Recruiting

FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC

for
Ovarian Cancer, Non-small Cell Lung Cancer
Location: New York NY, East Brunswick NJ, Fairfax VA, Columbus OH,
Sponsor: Tubulis GmbH

Sex: All

Age: 18+

Code: NCT06303505

Phase1, Phase2, Recruiting

This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors

for
Non Small Cell Lung Cancer,
Location: Boston MA, Austin, TX 78758 TX, San Antonio TX
Sponsor: Zumutor Biologics Inc.

Sex: All

Age: 18+

Code: NCT06451497

Phase1, Recruiting

Prospective Collection of Whole Blood From Active Non-Small Cell Lung Cancer Patients for Supplemental Research

for
Non Small Cell Lung Cancer
Location: Waltham MA
Sponsor: Sanguine Biosciences

Sex: All

Age: 18 - 70+

Code: NCT05669105

Recruiting

Phase I/IIa Study of H002 in NSCLC With Active EGFR Mutation

for
Non-small Cell Lung Cancer
Location: Boston MA, New York NY, Fairfax VA, Los Angeles CA
Sponsor: RedCloud Bio

Sex: All

Age: 18+

Code: NCT05519293

Phase1, Phase2, Recruiting

Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer

for
Non-small Cell Lung Cancer
Location: New Haven CT, Brooklyn NY, New York NY, Montreal,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT06350097

Phase3, Recruiting

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

for
Non-Small Cell Lung Cancer
Location: St. John's, Rimouski, Boston MA, Levis, Stony Brook NY,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT06357533

Phase3, Recruiting

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

for
Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer,
Location: Boston MA, New York NY, Fairfax VA, Pittsburgh PA,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT06128551

Phase1, Phase2, Recruiting

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

for
Breast Cancer, Gastric Cancer, Esophageal Cancer,
Location: New York NY, Nashville TN, Houston TX, Dallas TX,
Sponsor: Jazz Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06695845

Phase2, Recruiting

Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors

for
Advanced or Metastatic ER+ HER2- Breast Cancer (mBC),
Location: Boston MA, Sarasota FL, Grand Rapids MI, Nashville TN,
Sponsor: Olema Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT06784193

Phase1, Recruiting