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Active & Responsive

A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

for
Non-small Cell Lung Cancer
Location: Boston MA, New Haven CT, New York NY,
Sponsor: BioNTech SE

Sex: All

Age: 18+

Code: NCT07111520

Phase1, Phase2, Recruiting
Active & Responsive

A Study of Tolododekin Alfa (ANK-101) in Combination With an Anti-PD-1/PD-L1 Antibody in Participants With Advanced Non-Small Cell Lung Cancer

for
Non Small Cell Lung Cancer
Location: New York NY, Philadelphia PA, Coral Gables FL,
Sponsor: Ankyra Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT07027514

Phase1, Recruiting
Active & Responsive

A 2-part Phase 1/2 Open-label Trial on ODM-212

for
Mesothelioma, Pancreatic Cancer,
Location: Fairfax VA, Irving TX
Sponsor: Orion Corporation, Orion Pharma

Sex: All

Age: 18+

Code: NCT07563738

Phase1, Phase2, Recruiting
Active & Responsive

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

for
Solid Tumor Malignancies, Colorectal Carcinoma,
Location: Philadelphia PA, Fairfax VA, Orlando FL,
Sponsor: Tasca Therapeutics

Sex: All

Age: 18+

Code: NCT07030257

Phase1, Phase2, Recruiting
Active & Responsive

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

for
Solid Tumor, Non-Small-Cell Lung Cancer,
Location: New York NY, Hackensack NJ, Fairfax VA, Buffalo NY,
Sponsor: Astellas Pharma Inc

Sex: All

Age: 18+

Code: NCT07094204

Phase1, Recruiting

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Active & Responsive

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

for
Triple Negative Breast Cancer, HER2-negative Breast Cancer,
Location: Fairfax VA, Orlando FL, Huntersville NC, Sarasota FL,
Sponsor: Dren Bio

Sex: All

Age: 18+

Code: NCT06999187

Phase1, Recruiting
Active & Responsive

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

for
Head and Neck Carcinoma, Adenoid Cystic Carcinoma, Lung Cancer,
Location: Hartford CT, New York NY, Englewood NJ, Florham Park NJ,
Sponsor: VM Oncology, LLC

Sex: All

Age: 18 - 70+

Code: NCT03556228

Phase1, Phase2, Recruiting
Active & Responsive

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

for
Non-small Cell Lung Cancer, NSCLC
Location: Hackensack NJ, Trois-Rivieres, Pennington NJ, Montreal,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06422143

Phase3, Recruiting
Active & Responsive

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

for
Non-small Cell Lung Cancer, Histiocytic Neoplasm, Histiocytosis,
Location: Boston MA, New Haven CT, New York NY, Fairfax VA,
Sponsor: Institut de Recherches Internationales Servier

Sex: All

Age: 18+

Code: NCT05786924

Phase1, Phase2, Recruiting
Active & Responsive

Response of Bony Metastasis to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancers With Actionable Driver Mutations.

for
Carcinoma, Non-Small-Cell Lung
Location: Aurora CO, Lone Tree CO
Sponsor: University of Colorado, Denver

Sex: All

Age: 18 - 70+

Code: NCT03958565

Recruiting
Active & Responsive

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

for
Carcinoma, Non-Small-Cell Lung
Location: Halifax, Boston MA, Norwich CT, New Haven CT, Quebec,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06623422

Phase3, Recruiting
Active & Responsive

A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving Pembrolizumab

for
Metastatic Lung Non-Small Cell Carcinoma,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07619599

Phase1, Recruiting
Active & Responsive

A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment

for
Lung Non-Small Cell Carcinoma
Location: Bath ME, Brunswick ME, Portland ME, Scarborough ME,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 18+

Code: NCT07293247

Phase2, Recruiting
Active & Responsive

A Study of DM005 in Patients With Advanced Solid Tumors

for
Carcinoma, Non-Small-Cell Lung,
Location: Fairfax VA, Detroit MI, Dallas TX
Sponsor: Doma Biopharmaceutical（Suzhou）Co., Ltd.

Sex: All

Age: 18+

Code: NCT06515990

Phase1, Phase2, Recruiting
Active & Responsive

Using Microbiome to Predict Durvalumab Toxicity in Post- Concurrent Chemoradiation Therapy (CCRT) NSCLC Patients

for
NSCLC, Stage III, Locally Advanced Lung Carcinoma
Location: Kansas City KS
Sponsor: Jun Zhang, MD, PhD

Sex: All

Age: 18+

Code: NCT04680377

Recruiting
Active & Responsive

Durvalumab and Tremelimumab in Combination With Chemotherapy in HIV-infected Patients With Non-small Cell Lung Cancer

for
Carcinoma, Non-Small Cell Lung
Location: Baltimore MD, Washington D.C. DC
Sponsor: Georgetown University

Sex: All

Age: 18+

Code: NCT04499053

Phase2, Recruiting
Active & Responsive

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

for
Carcinoma, Non-Small-Cell Lung
Location: Lebanon NH, Philadelphia PA, Columbus OH, Houston TX,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT04165798

Recruiting
Active & Responsive

Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung Cancer

for
Advanced Lung Adenocarcinoma, Refractory Lung Adenocarcinoma,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT06495125

Phase2, Recruiting
Active & Responsive

An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.

for
Stomatitis
Location: Wynnewood PA, East Syracuse NY, Wilson NC, Athens GA,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07357597

Recruiting
Active & Responsive

A Study Comparing TAK-928 With Docetaxel in Adults With Non-Small Cell Lung Cancer

for
IO-resistant sqNSCLC
Location: Margate FL, Tamarac FL, Jonesboro AR, Houston TX,
Sponsor: Takeda

Sex: All

Age: 18+

Code: NCT07217301

Phase3, Recruiting