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Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases

for
Non Small Cell Lung Cancer, NSCLC, KRAS G12C
Location: Richmond VA, Charlottesville VA, Columbus OH
Sponsor: Ryan Gentzler, MD

Sex: All

Age: 18+

Code: NCT06248606

Phase2, Recruiting

A Study of KK2269 in Adult Participants With Solid Tumors

for
Advanced Solid Tumor, Metastatic Solid Tumor,
Location: Jacksonville FL, St Louis MO, Dallas TX, Scottsdale AZ,
Sponsor: Kyowa Kirin Co., Ltd.

Sex: All

Age: 18+

Code: NCT06266299

Phase1, Recruiting

BI-1910 as a Single Agent and in Combination With Pembrolizumab for the Treatment of Advanced Solid Tumors

for
Solid Tumors, Non Small Cell Lung Cancer,
Location: New Haven CT
Sponsor: BioInvent International AB

Sex: All

Age: 18+

Code: NCT06205706

Phase1, Phase2, Recruiting

T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer

for
Advanced Non-Small Cell Lung Cancer, Squamous Cell Carcinoma,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT02133196

Phase2, Recruiting

Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

for
Brain Metastases, Nonsmall Cell Lung Cancer Stage III
Location: Winston-Salem NC
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18+

Code: NCT05692635

Phase2, Recruiting

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An Adjuvant Study to Evaluate SMS001 (Paclitaxel) in Non-Small Cell Lung Cancer

for
Carcinoma, Non-Small-Cell Lung Cancer (NSCLC)
Location: Toronto, Rochester MN
Sponsor: ToLymph Inc.

Sex: All

Age: 18 - 70+

Code: NCT06693336

Phase2, Recruiting

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for
Non-small Cell Lung Cancer,
Location: Boston MA, New York NY, New Brunswick NJ, Pittsburgh PA,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT05877599

Phase1, Recruiting

Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)

for
Non-Small Cell Lung Cancer, NSCLC,
Location: Tappahannock VA, Richmond VA
Sponsor: Virginia Commonwealth University

Sex: All

Age: 18+

Code: NCT06731413

Phase2, Recruiting

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

for
Tumor Skin, Metastatic Melanoma, Melanoma, Lung Cancer,
Location: New York NY, Pittsburgh PA, Orlando FL, Louisville KY,
Sponsor: Obsidian Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06060613

Phase1, Phase2, Recruiting

Pembrolizumab for Advanced NSCLC and PS 2-3

for
Non-Small Cell Lung Cancer (NSCLC)
Location: New York NY
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All

Age: 18+

Code: NCT05589818

Phase2, Recruiting

Dietary Intervention for NSCLC Patients Treated With ICI

for
Non Small Cell Lung Cancer
Location: Montreal
Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All

Age: 18+

Code: NCT05805319

Recruiting

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

for
Locally Advanced Alveolar Soft Part Sarcoma,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06066138

Phase1, Recruiting

A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.

for
High-grade Serous Ovarian Carcinoma (HGSOC),
Location: Hackensack NJ, Montreal, Toronto, Vancouver,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT06476808

Phase1, Recruiting

Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

for
Non-small Cell Lung Cancer
Location: Boston MA, New Haven CT, Montreal, Baltimore MD,
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT05061550

Phase2, Recruiting

Study to Evaluate LB-LR1109, Administered Alone for the Treatment of Solid Tumor and in Combination With Atezolizumab for the Treatment of NSCLC

for
Non-small Cell Lung Cancer(NSCLC),
Location: Fairfax VA
Sponsor: LG Chem

Sex: All

Age: 18+

Code: NCT06332755

Phase1, Recruiting

Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

for
Advanced Solid Tumor, Cutaneous Tumor, Subcutaneous Tumor,
Location: Boston MA, Bethesda MD, Toronto, Pittsburgh PA,
Sponsor: Ankyra Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06171750

Phase1, Recruiting

Patient-centered, Optimal Integration of Survivorship and Palliative Care

for
Stage IV Non-small Cell Lung Cancer, Targeted Therapy,
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT04900935

Recruiting

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

for
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC),
Location: Boston MA, New Haven CT, New York NY, Baltimore MD,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT06040541

Phase1, Recruiting

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

for
Solid Tumor, Adult, Metastatic Solid Tumor, Refractory Cancer,
Location: Fairfax VA, Canton OH, Detroit MI, St Louis MO
Sponsor: Sairopa B.V.

Sex: All

Age: 18+

Code: NCT05856981

Phase1, Recruiting

Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

for
Brain Tumor, Non Small Cell Lung Cancer
Location: Providence RI, Baltimore MD, Fort Lauderdale FL,
Sponsor: InSightec

Sex: All

Age: 18 - 70+

Code: NCT05317858

Phase3, Recruiting