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Safety of Pentoxifylline and Vitamin E With Stereotactic Ablative Radiotherapy (SABR) in Non-small Cell Lung Cancers

for
Non-small Cell Lung Cancers
Location: Louisville KY
Sponsor: University of Louisville

Sex: All

Age: 18+

Code: NCT01871454

Phase2, Recruiting

A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Non-Squamous NSCLC

for
Non-squamous Non-small Cell Lung Cancer
Location: Saint John, South Portland ME, West Haven CT,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT06627647

Phase3, Recruiting

Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor

for
Patients With Non-Small Cell Lung Cancer
Location: Rimouski, Worcester MA, Norwich CT, Patchogue NY,
Sponsor: OSE Immunotherapeutics

Sex: All

Age: 18+

Code: NCT06472245

Phase3, Recruiting

A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

for
Advanced Non-small Cell Lung Cancer, HER2 Mutation
Location: Montreal, Fort Lauderdale FL, Toronto, Pittsburgh PA,
Sponsor: Bayer

Sex: All

Age: 18+

Code: NCT06452277

Phase3, Recruiting

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

for
Non-small Cell Lung Cancer
Location: Philadelphia PA, Baltimore MD, Lexington KY, Fargo ND,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06731907

Phase2, Recruiting

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Liver SBRT in Combination With Immune Checkpoint Inhibition in Patients With Metastatic Non-small Cell Lung Cancer

for
Liver Metastases, Non-small Cell Lung Cancer
Location: Ann Arbor MI
Sponsor: VA Ann Arbor Healthcare System

Sex: All

Age: 18+

Code: NCT05430009

Phase1, Recruiting

A Study of IBI363 in Subjects with Advanced Solid Malignancies

for
Melanoma, Non-small Cell Lung Cancer, Colorectal Cancer,
Location: Plantation FL, Ocala FL, Dearborn MI, Troy MI,
Sponsor: Innovent Biologics (Suzhou) Co. Ltd.

Sex: All

Age: 18+

Code: NCT06281678

Phase2, Recruiting

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

for
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC),
Location: Boston MA, New York NY, Baltimore MD, Fairfax VA,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT05379985

Phase1, Phase2, Recruiting

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

for
Non-Small Cell Lung Cancer (NSCLC)
Location: Halifax, Worcester MA, Montreal, Media PA, Newark DE,
Sponsor: Amgen

Sex: All

Age: 18 - 70+

Code: NCT05920356

Phase3, Recruiting

Neoadjuvant Dupilumab and Cemiplimab in Patients With Early-stage Resectable NSCLC

for
Non-Small Cell Lung Cancer
Location: New York NY
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All

Age: 18+

Code: NCT06088771

Phase1, Phase2, Recruiting

Safety and Immunogenicity of Recombinant DNA and Adenovirus Expressing L523S Protein in Early Stage Non-Small Cell Lung Cancer

for
Non-Small Cell Lung Cancer
Location: Ocoee FL, Tyler TX, Dallas TX, Spokane WA, Seattle WA
Sponsor: Corixa Corporation

Sex: All

Age: 18+

Code: NCT00062907

Phase1, Recruiting

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor, Melanoma, Head and Neck Cancer,
Location: New Haven CT, New York NY, Baltimore MD, Buffalo NY,
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT06172478

Phase2, Recruiting

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

for
Non-small Cell Lung Cancer, Anaplastic Lymphoma Kinase-positive
Location: Boston MA, Westbury NY, New York NY, Sellersville PA,
Sponsor: Nuvalent Inc.

Sex: All

Age: 18+

Code: NCT06765109

Phase3, Recruiting

Chest Lymph Node Sampling in Patients With Advanced Lung Cancer to be Treated With Curative-intent Radiation Treatment

for
Non-Small Cell Lung Cancer
Location: Toronto, London
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All

Age: 18+

Code: NCT04852588

Recruiting

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

for
Non-small Cell Lung Cancer (NSCLC)
Location: Westbrook ME, Mississauga, Brampton, Jacksonville FL,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06170788

Phase3, Recruiting

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

for
Advanced Solid Tumor, High Grade Serous Adenocarcinoma of Ovary,
Location: Providence RI, New Haven CT, New York NY, Baltimore MD,
Sponsor: Volastra Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05902988

Phase1, Phase2, Recruiting

A Phase 1/1b Study of IAM1363 in HER2 Cancers

for
HER2 Mutation-Related Tumors, HER2, HER2-positive Breast Cancer,
Location: Boston MA, Lebanon NH, New York NY, New Brunswick NJ,
Sponsor: Iambic Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06253871

Phase1, Recruiting

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for
Advanced Solid Tumors With KRAS G12C Mutations,
Location: Boston MA, Philadelphia PA, Fairfax VA, Detroit MI,
Sponsor: Frontier Medicines Corporation

Sex: All

Age: 18+

Code: NCT06244771

Phase1, Phase2, Recruiting

A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

for
Metastatic Solid Tumor, Advanced Solid Tumor,
Location: Boston MA, New York NY, Fairfax VA, Miami FL,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06561685

Phase1, Recruiting

Imaging of T-cell Activation With [18F]F-AraG in Advanced Non Small Cell Lung Cancer

for
Non Small Cell Lung Cancer
Location: Stony Brook NY, Sacramento CA, Palo Alto CA
Sponsor: CellSight Technologies, Inc.

Sex: All

Age: 18+

Code: NCT04726215

Phase2, Recruiting