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KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

for
Carcinoma, Non-Small-Cell Lung
Location: Lebanon NH, Philadelphia PA, Columbus OH, Houston TX,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT04165070

Phase1, Phase2, Recruiting

Microbiome in Immunotherapy naïve NSCLC Patients Receiving PD-1/L1 Blockade (MIP_NSCLC)

for
NSCLC Stage IV, NSCLC, Recurrent
Location: Kansas City KS, Fairway KS
Sponsor: Jun Zhang, MD, PhD

Sex: All

Age: 18+

Code: NCT04636775

Recruiting

A Tool for Improving the Shared Decision-making Process in Patients With Non-small Cell Lung Cancer

for
Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06122064

Recruiting

A Study Evaluating the Safety and Efficacy of HB0036 in Subjects With Advanced Solid Tumors

for
Advanced Solid Tumor, NSCLC
Location: Lafayette IN, San Antonio TX, Spokane WA
Sponsor: Shanghai Huaota Biopharmaceutical Co., Ltd.

Sex: All

Age: 18+

Code: NCT05417321

Phase1, Phase2, Recruiting

Thoracic Radiotherapy for Patients With Metastatic (Stage IV) Non-Small Cell Lung Cancer at High Risk of Symptomatic Progression Within the Thorax

for
Stage 4 NSCLC, Radiotherapy
Location: Rochester NY
Sponsor: University of Rochester

Sex: All

Age: 18+

Code: NCT06262321

Phase2, Recruiting

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Quality of Life Intervention to Inform Patient Decision-Making in Early-Stage Lung Cancer

for
Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8,
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 18+

Code: NCT05292521

Recruiting

Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

for
Solid Tumor, Adult, Mesothelioma, NSCLC
Location: Boston MA, New York NY, Arlington VA, Chicago IL,
Sponsor: Vivace Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT04665206

Phase1, Phase2, Recruiting

MRX-2843 and Osimertinib for the Treatment of Advanced EGFR Mutant Non-small Cell Lung Cancer

for
Advanced Lung Non-Small Cell Carcinoma,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT04762199

Phase1, Recruiting

A Pilot Phase II Study of Maintenance Cabozantinib Plus Pembrolizumab for Patients With Metastatic Squamous Non-Small Cell Lung Cancer (sqNSCLC)

for
Metastatic Squamous Non-Small Cell Lung Carcinoma
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 18+

Code: NCT05613413

Phase2, Recruiting

Lorlatinib Combinations in Lung Cancer

for
Lung Cancer, Anaplastic Lymphoma Kinase Gene Translocation,
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT04292119

Phase1, Phase2, Recruiting

Tocilizumab and Atezolizumab in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Refractory to 1st Line Immune Checkpoint Inhibitor-Based Therapy

for
Lung Cancer, Nonsmall Cell
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 18+

Code: NCT04691817

Phase1, Phase2, Recruiting

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

for
Melanoma, NSCLC, Hepatocellular Carcinoma, Urothelial Cancer,
Location: Pittsburgh PA
Sponsor: Dan Zandberg

Sex: All

Age: 18+

Code: NCT04114136

Phase2, Recruiting

Phase II Trial of Lung Chemoemobolization

for
Lung Non-Small Cell Carcinoma, Mediastinal Neoplasm,
Location: New York NY, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT05672108

Phase2, Recruiting

Adjuvant Pembrolizumab vs Observation Following Curative Resection for Stage I Non-small Cell Lung Cancer (NSCLC) With Primary Tumors Between 1-4 cm

for
NSCLC, Stage I
Location: New Brunswick NJ, Hershey PA, Richmond VA,
Sponsor: Greg Durm, MD

Sex: All

Age: 18+

Code: NCT04317534

Phase2, Recruiting

Peptide Vaccine To Prevent Acquired Resistance In Patients With Advanced ALK+ NSCLC

for
NSCLC Stage IV, ALK Fusion Protein Expression
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT05950139

Phase1, Phase2, Recruiting

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

for
Carcinoma, Non-Small-Cell Lung
Location: Boston MA, Farmington CT, New Haven CT, New York NY,
Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All

Age: 18+

Code: NCT06667908

Phase2, Recruiting

Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

for
Lung Non-Small Cell Carcinoma, Malignant Solid Neoplasm,
Location: Irvine CA, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT05830058

Phase2, Recruiting

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

for
Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8,
Location: Augusta ME, Scarborough ME, South Portland ME,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06498635

Phase3, Recruiting

Low-Dose Interleukin-2 and Pembrolizumab for the Treatment of Stage IV Non-Small Cell Lung Cancer

for
Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT05493566

Early_phase1, Recruiting

Combination of Atezolizumab and Pirfenidone in Second-line and Beyond NSCLC

for
NSCLC Stage IV, NSCLC, Recurrent
Location: Kansas City KS
Sponsor: University of Kansas Medical Center

Sex: All

Age: 18+

Code: NCT04467723

Phase1, Phase2, Recruiting