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A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

for
Carcinoma, Non-Small-Cell Lung
Location: Baltimore MD, Pittsburgh PA, Lexington KY
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06780085

Phase2, Recruiting

Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

for
Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8,
Location: Newnan GA, Zion IL, Goodyear AZ, Upland CA, Corona CA,
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07288034

Phase2, Recruiting

Diclofenac for the Treatment of Patients With Metastatic Non-small Cell Lung Cancer on Single Agent Immunotherapy

for
Advanced Lung Non-Small Cell Carcinoma,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT06731270

Phase2, Recruiting

Exercise Training for the Improvement of Immune Activity and Treatment Outcomes During Immunotherapy for Non-small Cell Lung Cancer, BOOST Trial

for
Lung Non-Small Cell Carcinoma
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT06983899

Recruiting

Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

for
PDAC, PDAC - Pancreatic Ductal Adenocarcinoma, NSCLC,
Location: Boston MA, New York NY, Washington D.C. DC, Fairfax VA,
Sponsor: Tango Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06922591

Phase1, Phase2, Recruiting

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Thoracic Radiotherapy and Inhibition of PD-1 and LAG-3 for Locally Advanced Non-Small Cell Lung Cancer

for
NSCLC, Locally Advanced
Location: The Bronx NY
Sponsor: Montefiore Medical Center

Sex: All

Age: 18+

Code: NCT06865339

Phase2, Recruiting

GT103 in Combination With Pembrolizumab for the Treatment of Advanced or Metastatic STK11 Mutant Non-Small Cell Lung Cancer

for
Advanced Lung Non-Small Cell Carcinoma,
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 18+

Code: NCT07017829

Phase2, Recruiting

The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer

for
Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8,
Location: Abington PA, Philadelphia PA, Willow Grove PA
Sponsor: Thomas Jefferson University

Sex: All

Age: 18+

Code: NCT05502523

Recruiting

Testing Tumor Tissue and Blood to Help Select Personalized Treatments for Patients With Suspected Lung Cancers

for
NSCLC
Location: Boston MA, Lebanon NH, New York NY, Fairfax VA,
Sponsor: Lung Cancer Mutation Consortium

Sex: All

Age: 0+

Code: NCT04712877

Recruiting

MYLUNG Consortium Part 3: Observational Study

for
Carcinoma, Non-Small-Cell Lung
Location: Albany NY, Newport News VA, Palm Bay FL, Blacksburg VA,
Sponsor: US Oncology Research

Sex: All

Age: 18+

Code: NCT05885698

Recruiting

A Study of Navlimetostat (BMS-986504) in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion (MountainTAP-9)

for
Carcinoma, Non-Small-Cell Lung
Location: Boston MA, New York NY, Canton OH, Detroit MI,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT06855771

Phase2, Recruiting

A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

for
Carcinoma, Non-small-Cell Lung
Location: Boston MA, Hackensack NJ, New Brunswick NJ,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT05498428

Phase2, Recruiting

Predictive Biomarkers for Pneumonitis After Chemoradiotherapy and Immunotherapy in Patients With Non-small Cell Lung Cancer

for
Lung Non-Small Cell Carcinoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 0+

Code: NCT04913311

Recruiting

Quaratusugene Ozeplasmid (Reqorsa) and Osimertinib in Patients With Advanced Lung Cancer Who Progressed on Osimertinib

for
Carcinoma, Non-Small Cell Lung
Location: Paramus NJ, Norfolk VA, Fairfax VA, Canton OH,
Sponsor: Genprex, Inc.

Sex: All

Age: 18+

Code: NCT04486833

Phase1, Phase2, Recruiting

A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

for
Carcinoma, Non-Small Cell Lung
Location: Westbury NY, Fresh Meadows NY, Philadelphia PA,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT06868277

Phase3, Recruiting

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for
Carcinoma, Non-Small-Cell Lung
Location: Westbrook ME, Worcester MA, Hartford CT, New York NY,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06890598

Phase3, Recruiting

PBF-1129 and Nivolumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

for
Metastatic Lung Non-Small Cell Carcinoma,
Location: Columbus OH
Sponsor: Dwight Owen

Sex: All

Age: 18+

Code: NCT05234307

Phase1, Recruiting

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for
Recurrent Lung Non-Small Cell Carcinoma,
Location: Brewer ME, Manchester NH, Worcester MA, Concord NH,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 0+

Code: NCT06031688

Phase2, Recruiting

Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation

for
Locally Advanced Lung Non-Small Cell Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05010109

Recruiting

Grid Radiation Therapy for the Treatment of Stage IV Non-Small Cell Lung Cancer

for
Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06660407

Phase2, Recruiting