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Local Consolidative Therapy and Durvalumab for Oligoprogressive and Polyprogressive Stage III NSCLC After Chemoradiation and Anti-PD-L1 Therapy

for
Stage III Lung Cancer AJCC v8,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04892953

Phase2, Recruiting

Confocal Laser Endomicroscopy VERification

for
Lung Cancer, Lung Neoplasm Malignant,
Location: New York NY
Sponsor: Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)

Sex: All

Age: 18+

Code: NCT06079970

Recruiting

Split Course Adaptive Radiation Therapy With Pembrolizumab With/Without Chemotherapy for Treating Stage IV Lung Cancer

for
Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8,
Location: Nashville TN
Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All

Age: 18+

Code: NCT05501665

Phase1, Phase2, Recruiting

A Study of Sofe-M in Participants With Selected Advanced Solid Tumors

for
Ovarian Neoplasms, Endometrial Neoplasms,
Location: Mineola NY, New York NY, Columbus OH, Grand Rapids MI,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06400472

Phase1, Recruiting

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

for
Anatomic Stage III Breast Cancer AJCC v8,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 16+

Code: NCT05269381

Phase1, Phase2, Recruiting

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Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Commack NY, Uniondale NY, Mineola NY, Harrison NY,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT06500481

Phase3, Recruiting

The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors

for
Non-Small-Cell Lung Carcinoma, Malignant Melanoma,
Location: Elizabethtown KY
Sponsor: VastBiome

Sex: All

Age: 18+

Code: NCT05037825

Recruiting

Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

for
Advanced Biliary Tract Carcinoma,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT07405086

Recruiting

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

for
Non-Small-Cell Lung, Esophageal Cancer, Cutaneous Melanoma
Location: New Haven CT, Trumbull CT, Fairfax VA, Nashville TN,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07519655

Phase1, Recruiting

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

for
Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma,
Location: Boston MA, New York NY, Fairfax VA, Durham NC,
Sponsor: Plexium, Inc.

Sex: All

Age: 18+

Code: NCT07284186

Phase1, Recruiting

Intratumoral N17350 in Advanced Solid Tumors

for
Neoplasms, Solid Tumor, Breast Neoplasms, Triple-Negative,
Location: Buffalo NY
Sponsor: Onchilles Pharma Inc

Sex: All

Age: 18+

Code: NCT07339176

Phase1, Phase2, Recruiting

Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer

for
Clinical Stage 0 Cutaneous Melanoma AJCC v8,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03819296

Phase1, Recruiting

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for
Breast Carcinoma, Colorectal Carcinoma,
Location: Rockport ME, Belfast ME, Brunswick ME, Augusta ME,
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18+

Code: NCT06418204

Recruiting

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

for
Early Stage Triple-Negative Breast Carcinoma,
Location: Jacksonville FL, Rochester MN, Phoenix AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06349642

Recruiting

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

for
Advanced Esophageal Squamous Cell Carcinoma,
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06265285

Phase2, Recruiting

A Study of PHN-012 in Patients With Advanced Solid Tumors

for
Colon Cancer, Pancreatic Cancer, Lung Cancer (NSCLC),
Location: Boston MA, Washington D.C. DC, Fairfax VA, Durham NC,
Sponsor: Pheon Therapeutics

Sex: All

Age: 18+

Code: NCT07127874

Phase1, Recruiting

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

for
Solid Tumors, Advanced Cancer, Renal Cancer, Gastric Cancer,
Location: Montreal, Hershey PA, Chapel Hill NC, Toronto,
Sponsor: Apollomics Inc.

Sex: All

Age: 18+

Code: NCT03175224

Phase2, Recruiting

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

for
Advanced/Metastatic Solid Tumors, Colorectal Cancer,
Location: Boston MA, New York NY, Philadelphia PA, Syracuse NY,
Sponsor: Merus B.V.

Sex: All

Age: 18+

Code: NCT03526835

Phase1, Phase2, Recruiting

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

for
HNSCC, ESCC, Esophageal Adenocarcinoma, Gastric Adenocarcinoma,
Location: Boston MA, New Haven CT, Hackensack NJ, Philadelphia PA,
Sponsor: Normunity AccelCo, Inc.

Sex: All

Age: 18+

Code: NCT07182149

Phase1, Recruiting

A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

for
Solid Tumor, Melanoma, HNSCC, Sarcoma, Squamous Cell Carcinoma,
Location: Boston MA, Fairfax VA, Pittsburgh PA, Dallas TX
Sponsor: ImmVira Pharma Co. Ltd

Sex: All

Age: 18+

Code: NCT04370587

Phase1, Phase2, Recruiting