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A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs

for
Lung Cancer, Non-small Cell, Lung Cancer Metastatic,
Location: Weston FL, Canton OH, Cleveland OH, Detroit MI,
Sponsor: Krystal Biotech, Inc.

Sex: All

Age: 18+

Code: NCT06228326

Phase1, Phase2, Recruiting

A Phase 2 Trial to Assess Safety and Efficacy of Tofacitinib 2% Cream in the Treatment of Cutaneous T-cell Lymphoma (CTCL), Stages IA, IB, and IIA

for
Cutaneous T-Cell Lymphoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06698822

Phase2, Recruiting

A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors

for
Metastatic Castration-Resistant Prostate Cancer (mCRPC),
Location: Boston MA, Providence RI, New Haven CT, New York NY,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT03972657

Phase1, Phase2, Recruiting

A Phase II, Single-center, Single-arm Study Evaluating the Safety and Efficacy of Golidocitinib in the Management of Newly Diagnosed Peripheral T Cell Lymphoma Patients (GOLDEN Study) and Correlative Study

for
Peripheral T Cell Lymphoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06630091

Phase2, Recruiting

A Phase 1/2, Open-label, Multicenter, FIH Study to Evaluate Safety, Tolerability, PK and Anti-tumor Activity of YH42946

for
NSCLC (Non-small Cell Lung Cancer), Solid Tumor
Location: Fairfax VA
Sponsor: Yuhan Corporation

Sex: All

Age: 18+

Code: NCT06616766

Phase1, Phase2, Recruiting

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Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

for
Advanced Lung Non-Small Cell Carcinoma,
Location: Brewer ME, South Weymouth MA, Boston MA, Brighton MA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 70+

Code: NCT06096844

Phase3, Recruiting

Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer

for
Non-small Cell Lung Cancer
Location: Baltimore MD, Pinehurst NC, Athens GA, Glendale CA
Sponsor: Teligene US

Sex: All

Age: 18+

Code: NCT05168566

Phase2, Recruiting

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

for
Advanced Solid Tumor, Metastatic Cancer, Cutaneous Melanoma,
Location: Morristown NJ, Miami FL, Huntersville NC,
Sponsor: Aulos Bioscience, Inc.

Sex: All

Age: 18+

Code: NCT05267626

Phase1, Phase2, Recruiting

A First-in-human Study of PRTH-101 Monotherapy +/- Pembrolizumab in Subjects With Advanced Malignancies

for
Advanced or Metastatic Solid Tumors, Non Small Cell Lung Cancer,
Location: Boston MA, New Haven CT, Fairfax VA, Nashville TN,
Sponsor: Incendia Therapeutics

Sex: All

Age: 18+

Code: NCT05753722

Phase1, Recruiting

Phase 2 Study of Fingolimod in Lung Cancers

for
Non Small Cell Lung Cancer, Small-cell Lung Cancer
Location: Charleston SC
Sponsor: Medical University of South Carolina

Sex: All

Age: 18+

Code: NCT06424067

Phase2, Recruiting

A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

for
Well Differentiated Liposarcoma, Dedifferentiated Liposarcoma,
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06843967

Phase1, Phase2, Recruiting

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

for
Advanced Lung Non-Squamous Non-Small Cell Carcinoma,
Location: Worcester MA, Waterford CT, Guilford CT, Glastonbury CT,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT04181060

Phase3, Recruiting

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

for
Lung Non-Small Cell Carcinoma
Location: Brewer ME, Gloucester MA, Beverly MA, Peabody MA,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT06116682

Phase2, Recruiting

A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)

for
Non Small Cell Lung Cancer,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05657873

Phase2, Recruiting

Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer

for
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Columbus OH
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT06323460

Phase2, Recruiting

Incentive Spirometry to Improve Outcomes in Lung Cancer Patients Undergoing Concurrent Chemotherapy and Radiation Therapy

for
Lung Cancer, Pneumonitis, Radiation-Induced Lung Injury,
Location: Camden NJ
Sponsor: The Cooper Health System

Sex: All

Age: 18+

Code: NCT06688422

Recruiting

A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC)

for
HPV, Oropharynx Cancer, HPV-Related Carcinoma,
Location: Commack NY, Rockville Centre NY, East White Plains NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05307939

Phase2, Recruiting

A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

for
Non-small Cell Lung Cancer
Location: New York NY, Lancaster PA, Greenville NC, Syracuse NY,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT06561386

Phase3, Recruiting

Using ctDNA to Determine Therapies for Lung Cancer

for
Non Small Cell Lung Cancer, Complete Surgical Resection,
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT04966663

Phase2, Recruiting

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

for
Metastatic Malignant Neoplasm in the Liver,
Location: Westerly RI, Waterford CT, Guilford CT, Glastonbury CT,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT05040360

Phase2, Recruiting