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A Study to Compare the Efficacy and Safety of BMS-986489 (Atigotatug+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

for
Extensive-Stage Small Cell Lung Cancer
Location: Durham NC, Roanoke VA, Orange City FL, Fort Myers FL,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT06646276

Phase3, Recruiting

Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Cancer of Variant Histology

for
Bladder Squamous Cell Carcinoma,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT05756569

Phase2, Recruiting

Locally ablatiVe therApy in oLigO-pRogressive sOlid tUmorS (VALOROUS)

for
Breast Cancer, Oligoprogressive, Head and Neck Cancer, Sarcoma,
Location: Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT06103669

Recruiting

DALY II USA/ MB-CART2019.1 for DLBCL

for
Refractory Diffuse Large B Cell Lymphoma (DLBCL),
Location: Boston MA, New Haven CT, New York NY, Baltimore MD,
Sponsor: Miltenyi Biomedicine GmbH

Sex: All

Age: 18+

Code: NCT04792489

Phase2, Recruiting

Adaptive Radiation in Anal Cancer

for
Anal Squamous Cell Carcinoma
Location: New York NY
Sponsor: Columbia University

Sex: All

Age: 18+

Code: NCT05838391

Recruiting

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Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

for
Bladder Adenocarcinoma, Bladder Clear Cell Adenocarcinoma,
Location: Peabody MA, Burlington MA, Commack NY, Uniondale NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT03866382

Phase2, Recruiting

Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors

for
Ovarian Cancer, Lung Adenocarcinoma, Endometrial Cancer,
Location: Boston MA, Providence RI, Montreal, Fairfax VA, Toronto,
Sponsor: AstraZeneca

Sex: All

Age: 18 - 70+

Code: NCT05797168

Phase1, Phase2, Recruiting

GEMINI-NSCLC: NSCLC Biomarker Study

for
Non-Small Cell Lung Cancer
Location: Norwich CT, White Plains NY, New York NY, Belleville NJ,
Sponsor: Tempus AI

Sex: All

Age: 18+

Code: NCT05236114

Recruiting

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

for
Non-Small Cell Lung Cancer
Location: Milford MA, Weymouth MA, Brighton MA, Boston MA,
Sponsor: Summit Therapeutics

Sex: All

Age: 18+

Code: NCT06767514

Phase3, Recruiting

Study Evaluating UCART20x22 in B-Cell Non-Hodgkin Lymphoma

for
B-cell Non-Hodgkin Lymphoma (B-NHL)
Location: Boston MA, New Brunswick NJ, Chicago IL, Austin TX
Sponsor: Cellectis S.A.

Sex: All

Age: 18 - 70+

Code: NCT05607420

Phase1, Phase2, Recruiting

Anti-CD7 CAR-T Cells in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia or Lymphoma

for
T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Location: Philadelphia PA
Sponsor: Stephan Grupp MD PhD

Sex: All

Age: 0 - 29

Code: NCT06934382

Phase1, Recruiting

AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

for
Acute Leukemia, Severe Aplastic Anemia, Non-hodgkin Lymphoma,
Location: Valhalla NY
Sponsor: Mitchell Cairo

Sex: All

Age: 0 - 30

Code: NCT04099966

Phase2, Recruiting

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

for
Acute Lymphoblastic Leukemia in Remission,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18 - 70+

Code: NCT03670966

Phase1, Phase2, Recruiting

Study of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

for
Mantle Cell Lymphoma, Follicular Lymphoma,
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT04223765

Phase1, Recruiting

Study of Osimertinib With Carotuximab in Advanced, EGFR-mutated Non-Small Cell Lung Cancer

for
Non Small Cell Lung Cancer, Lung Cancer
Location: Los Angeles CA, Beverly Hills CA, Torrance CA
Sponsor: Karen Reckamp, MD, MS

Sex: All

Age: 18+

Code: NCT05401110

Phase1, Recruiting

Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

for
Clear Cell Renal Cell Carcinoma, Renal Cell Carcinoma (RCC),
Location: Brewer ME, Gloucester MA, South Weymouth MA, Beverly MA,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 18+

Code: NCT06661720

Phase3, Recruiting

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

for
Solid Tumors With HRAS Alterations,
Location: Boston MA, New Brunswick NJ, Pittsburgh PA,
Sponsor: Kura Oncology, Inc.

Sex: All

Age: 18+

Code: NCT06026410

Phase1, Recruiting