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Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)

for
Non-Small Cell Lung Cancer, NSCLC,
Location: Tappahannock VA, Richmond VA
Sponsor: Virginia Commonwealth University

Sex: All

Age: 18+

Code: NCT06731413

Phase2, Recruiting

A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER)

for
Breast, Metastatic, Triple Negative, Cancer,
Location: Los Angeles CA
Sponsor: University of Southern California

Sex: All

Age: 18 - 70+

Code: NCT04333706

Phase1, Phase2, Recruiting

Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers

for
Esophageal Cancer, Head and Neck Cancer, Lung Cancer,
Location: Aurora CO
Sponsor: University of Colorado, Denver

Sex: All

Age: 21 - 70+

Code: NCT00900419

Recruiting

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

for
Solid Tumor, Advanced Cancer, Metastatic Cancer, Gastric Cancer,
Location: Boston MA, New York NY, Madison WI, Aurora CO,
Sponsor: I-Mab Biopharma US Limited

Sex: All

Age: 18+

Code: NCT04900818

Phase1, Recruiting

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

for
Tumor Skin, Metastatic Melanoma, Melanoma, Lung Cancer,
Location: New York NY, Pittsburgh PA, Orlando FL, Louisville KY,
Sponsor: Obsidian Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06060613

Phase1, Phase2, Recruiting

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Home-based Respiratory Muscle Training for Minimizing Side Effects in Patients Undergoing Treatment for Cancer

for
Breast Carcinoma, Head and Neck Cancer, Lung Cancer
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 21+

Code: NCT05787834

Recruiting

Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial

for
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT06636734

Phase2, Recruiting

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

for
Metastatic Malignant Solid Neoplasm, Metastatic Melanoma,
Location: Duarte CA, Los Angeles CA, Stanford CA
Sponsor: Anusha Kalbasi

Sex: All

Age: 18 - 70+

Code: NCT04119024

Phase1, Recruiting

Safety and Efficacy of Epcoritamab With Gemcitabine, Dexamethasone, and Cisplatin (GDP) Salvage Chemotherapy in Relapsed Refractory Large B-cell Lymphoma

for
Large Cell Lymphoma, Diffuse, Relapsed Cancer,
Location: Charlottesville VA, Detroit MI, Indianapolis IN,
Sponsor: Dipenkumar Modi

Sex: All

Age: 18+

Code: NCT05852717

Phase2, Recruiting

Pembrolizumab for Advanced NSCLC and PS 2-3

for
Non-Small Cell Lung Cancer (NSCLC)
Location: New York NY
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All

Age: 18+

Code: NCT05589818

Phase2, Recruiting

PET/CT Imaging of Small Cell Lung Cancer Using 89Zr-DFO-SC16.56

for
Small Cell Lung Cancer, Small Cell Lung Carcinoma
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT04199741

Phase1, Phase2, Recruiting

Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer

for
Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Location: Rimouski, Montreal, Easton PA, Miami FL, Toronto,
Sponsor: Gilead Sciences

Sex: All

Age: 18+

Code: NCT06801834

Phase3, Recruiting

Tocilizumab and Atezolizumab in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Refractory to 1st Line Immune Checkpoint Inhibitor-Based Therapy

for
Lung Cancer, Nonsmall Cell
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 18+

Code: NCT04691817

Phase1, Phase2, Recruiting

Establishing a Tumor Registry for Patients With Neuroendocrine Carcinoma of the Cervix

for
Cervical Large Cell Neuroendocrine Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 0+

Code: NCT04723095

Recruiting

Access to Genetic Testing in Underserved Patients With Cancer

for
Breast Carcinoma, Male Breast Carcinoma,
Location: Rochester NY, Los Angeles CA
Sponsor: University of Southern California

Sex: All

Age: 18+

Code: NCT06422455

Recruiting

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

for
Locally Advanced Alveolar Soft Part Sarcoma,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06066138

Phase1, Recruiting

Phase II Trial of Lung Chemoemobolization

for
Lung Non-Small Cell Carcinoma, Mediastinal Neoplasm,
Location: New York NY, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT05672108

Phase2, Recruiting

A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.

for
High-grade Serous Ovarian Carcinoma (HGSOC),
Location: Hackensack NJ, Montreal, Toronto, Vancouver,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT06476808

Phase1, Recruiting

Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders

for
Kidney Cancer, Urologic Malignant Disorders,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 2+

Code: NCT00001238

Recruiting

A Study of ZEN003694 in People With Squamous Cell Lung Cancer

for
Squamous Cell Lung Cancer
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05607108

Phase2, Recruiting