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Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma

for
Cutaneous Squamous Cell Carcinoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06567314

Phase2, Recruiting

Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas

for
Sarcoma, Sarcoma, Ewing, Desmoplastic Small Round Cell Tumor,
Location: Boston MA
Sponsor: David S Shulman, MD

Sex: All

Age: 12 - 49

Code: NCT06709495

Phase1, Phase2, Recruiting

Modified Immune Cells (CD19 CAR T Cells) and Acalabrutinib for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

for
Recurrent Mantle Cell Lymphoma, Refractory Mantle Cell Lymphoma
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18 - 70+

Code: NCT04484012

Phase2, Recruiting

Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

for
Cutaneous Squamous Cell Carcinoma (CSCC)
Location: Beverly MA, Portsmouth NH, Boston MA, New York NY,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06585410

Phase3, Recruiting

Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors

for
Pancreatic Ductal Adenocarcinoma, Non-Small Cell Lung Cancer,
Location: Montreal
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18 - 70+

Code: NCT07261631

Phase1, Recruiting

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Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE)

for
Adenocarcinoma of the Bladder,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06041503

Phase2, Recruiting

Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

for
Giant Cell Tumor of Bone
Location: Boston MA, Baltimore MD, Pittsburgh PA, Cleveland OH,
Sponsor: St. Louis University

Sex: All

Age: 18+

Code: NCT03295981

Phase3, Recruiting

Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (ViPOR) in Relapsed/Refractory B-cell Lymphoma

for
Lymphoma, Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT03223610

Phase1, Phase2, Recruiting

Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution

for
Hematologic Malignancy, Leukemia, Lymphoma,
Location: Cincinnati OH, Milwaukee WI, Houston TX, Aurora CO
Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All

Age: 0 - 38

Code: NCT06131801

Recruiting

Phase II Study of Pirtobrutinib With Venetoclax In Relapsed-Refractory MCL (Mantle Cell Lymphoma) Patients

for
Mantle Cell Lymphoma, Non Hodgkin Lymphoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05529069

Phase2, Recruiting

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Thiotepa in Treating Patients With Non-malignant Disorders

for
Non-Neoplastic Hematopoietic and Lymphoid Cell Disorder
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 0 - 50

Code: NCT03980769

Phase2, Recruiting

Nisin in Oral Cavity Squamous Cell Carcinoma (OCSCC)

for
Oral Cavity Squamous Cell Carcinoma
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT06097468

Phase1, Phase2, Recruiting

Autologous T-Cells Expressing a Second Generation CAR for Treatment of T-Cell Malignancies Expressing CD5 Antigen

for
T-cell Acute Lymphoblastic Lymphoma, T-non-Hodgkin Lymphoma,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 0 - 70+

Code: NCT03081910

Phase1, Recruiting

Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)

for
Esophageal Squamous Cell Carcinoma
Location: Pittsburgh PA
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06780111

Phase1, Phase2, Recruiting

STRatIfication of Vulvar SCC by HPV and p53 Status to Guide Excision

for
Vulvar Squamous Cell Carcinoma
Location: Quebec, Sherbrooke, Montreal, Toronto, Hamilton, Regina,
Sponsor: Canadian Cancer Trials Group

Sex: Female

Age: 18+

Code: NCT06358469

Recruiting

Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling

for
Recurrent Childhood Acute Myeloid Leukemia,
Location: Miami FL
Sponsor: Florida International University

Sex: All

Age: 0 - 21

Code: NCT05857969

Phase1, Recruiting

Stereotactic Body Proton Therapy for Treatment of Primary Renal Cell Carcinoma

for
Renal Cell Carcinoma
Location: Washington D.C. DC
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT06376669

Phase2, Recruiting

The Impact of COVID-19 on Pulmonary Procedures

for
COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 0+

Code: NCT05022446

Recruiting

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

for
Primary T-cell Immunodeficiency Disorders,
Location: Bethesda MD, Minneapolis MN
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 4 - 70+

Code: NCT02579967

Phase2, Recruiting

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

for
Adipocytic Neoplasm, Liposarcoma, Atypical Fibroxanthoma,
Location: Boston MA, Atlanta GA, Cincinnati OH, Chicago IL,
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 30

Code: NCT06239272

Phase1, Phase2, Recruiting