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Preliminary Safety and Tolerability of CD19x22 CAR T Cells in Adolescent and Adult R/R B-NHL Patients

for
Non-Hodgkin Lymphoma, B-cell Non-Hodgkin Lymphoma (B-NHL),
Location: Aurora CO
Sponsor: University of Colorado, Denver

Sex: All

Age: 16+

Code: NCT05098613

Phase1, Recruiting

A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)

for
Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia,
Location: New York NY, Philadelphia PA, San Antonio TX,
Sponsor: Autolus Limited

Sex: All

Age: 0 - 18

Code: NCT06173518

Phase1, Recruiting

Sample Collection for Ongoing Research and Product Evaluation Study - Non-Hodgkin Lymphoma (SCORE-NHL)

for
Non-Hodgkin Lymphoma, T-Cell Lymphoma,
Location: Austin TX
Sponsor: Natera, Inc.

Sex: All

Age: 18+

Code: NCT07750886

Recruiting

Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma

for
Oropharyngeal Carcinoma,
Location: New York NY
Sponsor: NYU Langone Health

Sex: All

Age: 18+

Code: NCT03215719

Phase2, Recruiting

A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors

for
Clear Cell Renal Cell Carcinoma, Solid Tumors
Location: Boston MA, New York NY, Baltimore MD, Miami FL,
Sponsor: Arcus Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT05536141

Phase1, Recruiting

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A Study to Evaluate the Impact of Mosunetuzumab Consolidation for Older Patients With Diffuse Large B-cell Lymphoma (DLBCL) Who Have Detectable Amounts of ctDNA (Circulating Tumor DNA) at the End of Treatment With Pola-R-mini-CHP

for
Diffuse Large B-Cell Lymphoma (DLBCL)
Location: Rochester NY
Sponsor: Danielle Wallace

Sex: All

Age: 70+

Code: NCT06828991

Phase2, Recruiting

Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

for
T-cell Acute Lymphoblastic Leukemia, T-cell Lymphoma,
Location: Charlotte NC, Memphis TN, Tulsa OK, San Diego CA
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 1 - 18

Code: NCT06390319

Phase2, Recruiting

Acalabrutinib Maintenance for the Treatment of Patients With Large B-cell Lymphoma

for
Diffuse Large B-Cell Lymphoma, High-grade B-cell Lymphoma,
Location: Los Angeles CA, Sacramento CA
Sponsor: Jonsson Comprehensive Cancer Center

Sex: All

Age: 18 - 70

Code: NCT05256641

Phase1, Phase2, Recruiting

A Study of Glofitamab-based Treatment in People With Diffuse Large B-cell Lymphoma

for
Diffuse Large B Cell Lymphoma (DLBCL),
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 65 - 70+

Code: NCT06765317

Phase2, Recruiting

Expressive Writing for the Management of Stress in Cancer Survivors

for
Hematopoietic and Lymphoid Cell Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04776941

Recruiting

A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)

for
Sickle Cell Disease, Thalassemia, Beta, Thalassemia
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 2 - 50

Code: NCT05736419

Phase2, Recruiting

A Study of APG-3288 in Relapsed/Refractory Blood Cancers

for
Relapsed/Refractory Hematological Malignancies,
Location: East Brunswick NJ, Grand Rapids MI, Los Angeles CA
Sponsor: Ascentage Pharma Group Inc.

Sex: All

Age: 18+

Code: NCT07424833

Phase1, Recruiting

Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell Lymphoma

for
Mantle Cell Lymphoma
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT06572618

Phase2, Recruiting

A Phase II Study of Loncastuximab Tesirine as Consolidation Strategy in Patients With LBCL in PR After CAR T-cell Therapy

for
Large B-cell Lymphoma, Lymphoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05464719

Phase2, Recruiting

Developing Restful Environments and Management Strategies for Pediatric Stem Cell Transplant Patients

for
Stem Cell Transplant Complications, Sleep Disturbance
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 9 - 17

Code: NCT06468618

Recruiting

Outpatient Epcoritamab in Large B-cell Lymphoma

for
Relapsed Large B-cell Lymphoma,
Location: Boston MA, Newton MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT06811272

Phase2, Recruiting

Epcoritamab Plus Ibrutinib for the Treatment of Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphoma

for
Recurrent Diffuse Large B-Cell Lymphoma,
Location: Richmond VA, Columbus OH, Minneapolis MN
Sponsor: Yazeed Sawalha

Sex: All

Age: 18+

Code: NCT06536049

Phase1, Phase2, Recruiting

Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal Reconstruction

for
Squamous Cell Carcinoma, Pharyngocutaneous Fistula
Location: Pittsburgh PA
Sponsor: Matthew Spector

Sex: All

Age: 18+

Code: NCT06831149

Phase2, Recruiting

Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design

for
Squamous Cell Carcinoma
Location: Pittsburgh PA
Sponsor: Christopher Wilke

Sex: All

Age: 18+

Code: NCT02128906

Phase2, Recruiting

A Pilot Phase II Study of Maintenance Cabozantinib Plus Pembrolizumab for Patients With Metastatic Squamous Non-Small Cell Lung Cancer (sqNSCLC)

for
Metastatic Squamous Non-Small Cell Lung Carcinoma
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 18+

Code: NCT05613413

Phase2, Recruiting