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Active & Responsive

Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy as First-line or Second-line Treatment

for
Non-small Cell Lung Cancer
Location: New York NY, Tampa FL, Elizabethtown KY, Birmingham AL
Sponsor: BioNTech SE

Sex: All

Age: 18+

Code: NCT06841055

Phase2, Recruiting
Active & Responsive

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors, Genital Neoplasm, Female,
Location: Boston MA, Bethesda MD, Toronto, Celebration FL,
Sponsor: Marengo Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05592626

Phase1, Phase2, Recruiting
Active & Responsive

Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's Choice of Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer

for
Advanced Non-squamous Non-small-cell Lung Cancer,
Location: Mullica Hill NJ, Miami FL, Plantation FL,
Sponsor: Genelux Corporation

Sex: All

Age: 18+

Code: NCT06463665

Phase2, Recruiting
Active & Responsive

Safety Trial of Antimicrobial Therapy and Precision Radiation Therapy in Patients With Oligoprogressive Non-small Cell Lung Cancer

for
Early Stage Non-Small Cell Lung Cancer
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 18+

Code: NCT03546829

Phase1, Recruiting
Active & Responsive

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

for
Non-Small Cell Lung Cancer
Location: Baltimore MD, Fairfax VA, Columbus OH, Lexington KY,
Sponsor: BioNTech SE

Sex: All

Age: 18+

Code: NCT05142189

Phase1, Recruiting

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Active & Responsive

Multicenter Clinical Trial of ST-02 for Ablation of Upper Tract Urothelial Carcinoma

for
Urothelial Carcinoma of the Renal Pelvis and Ureter,
Location: Halifax, Montreal, Toronto, London, Winnipeg, Vancouver
Sponsor: Peter Black

Sex: All

Age: 18+

Code: NCT06124976

Phase2, Phase3, Recruiting
Active & Responsive

A Phase 1 and 2 Study of VMD-102 in Hepatocellular Carcinoma and Other Solid Tumors

for
Hepatocellular Carcinoma (HCC), Metastatic Uveal Melanoma,
Location: Scottsdale AZ
Sponsor: VM Discovery, Inc.

Sex: All

Age: 18 - 70+

Code: NCT07636785

Phase1, Phase2, Recruiting
Active & Responsive

A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving Pembrolizumab

for
Metastatic Lung Non-Small Cell Carcinoma,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07619599

Phase1, Recruiting
Active & Responsive

Phase 1 Study Of Izalontamab Brengitecan + Adagrasib In NSCLC - The IZA-A Trial

for
Non-small Cell Lung Cancer
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT07382726

Phase1, Recruiting
Active & Responsive

First-Line Ipilimumab Plus Nivolumab and Nogapendekin Alfa Inbakicept (N-803) in Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer

for
Non-small Cell Lung Cancer Stage IV,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT07355205

Phase1, Phase2, Recruiting
Active & Responsive

Zanzalintinib for Metastatic Clear Cell Renal Cell Carcinoma With Bone Metastases

for
Clear Cell Renal Cell Cancer (ccRCC),
Location: San Francisco CA
Sponsor: Kelly Fitzgerald, MD

Sex: All

Age: 18+

Code: NCT07043608

Phase2, Recruiting
Active & Responsive

A Study To Assess the Safety, Tolerability, and Efficacy of Imzokitug in Combination With Pumitamig and Platinum-Doublet Chemotherapy (PDCT) Versus Pumitamig and PDCT as First-line Treatment for Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

for
Locally Advanced Non-Small Cell Lung Cancer (NSCLC),
Location: Omaha NE, Grand Island NE
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT07680764

Phase2, Recruiting
Active & Responsive

TCR1188-ABC Cells in KRAS-mutated Cancers

for
Cholangiocarcinoma, Colorectal Cancer,
Location: Philadelphia PA
Sponsor: University of Pennsylvania

Sex: All

Age: 18+

Code: NCT07594067

Phase1, Recruiting
Active & Responsive

Clonal Hematopoiesis Chemotherapy and Radiation Effects Study

for
Lung Cancer (Diagnosis), Osteochondroma, Spitz Nevus,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT07675967

Recruiting
Active & Responsive

The EASE Study: Randomized Trial of a Novel Approach to Addressing Fear of Progression in Advanced Cancer

for
Advanced Solid Tumor Cancer,
Location: Aurora CO, Boulder CO
Sponsor: University of Colorado, Boulder

Sex: All

Age: 18+

Code: NCT07636200

Recruiting
Active & Responsive

A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)

for
Non-small Cell Lung Cancer
Location: Albany NY, Raleigh NC, Lincoln NE
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07554339

Phase3, Recruiting
Active & Responsive

Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors

for
Sub-study 1 Cervical Cancer (Volrustomig Monotherapy),
Location: Stony Brook NY, New York NY, Montreal, Baltimore MD,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT06535607

Phase2, Recruiting
Active & Responsive

A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)

for
Non-small Cell Lung Cancer
Location: New Haven CT, White Plains NY, Albany NY, Montreal,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07513376

Phase3, Recruiting
Active & Responsive

Risk-adapted, Proteomic-guided Systemic Therapy for Previously Untreated Advanced Non-small Cell Lung Cancer

for
Non-small Cell Lung Cancer Stage IIIC,
Location: Truckee CA, Chico CA, Marysville CA, Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT07250477

Phase2, Recruiting
Active & Responsive

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

for
Advanced Solid Tumors, Metastatic Solid Tumors,
Location: Norwich CT, Fairfax VA, Nashville TN, Saint Paul MN,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT07397338

Phase1, Phase2, Recruiting