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Neoadjuvant PD-1 Blockade in Resectable Merkel Cell Carcinoma

for
Merkel Cell Carcinoma
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 18+

Code: NCT05496036

Phase2, Recruiting

A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma

for
Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06736613

Phase2, Recruiting

Addition of Cord Blood Tissue-Derived Mesenchymal Stromal Cells to Ruxolitinib for the Treatment of Steroid-Refractory Acute Graft Versus Host Disease

for
Hematopoietic and Lymphoid Cell Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 12 - 70+

Code: NCT04744116

Early_phase1, Recruiting

Venetoclax, SL-401, and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm

for
Blastic Plasmacytoid Dendritic Cell Neoplasm
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04216524

Phase2, Recruiting

Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

for
Extensive Stage Lung Small Cell Carcinoma,
Location: Peabody MA, Boston MA, Burlington MA, Waterford CT,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT06769126

Phase2, Recruiting

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Autologous HuCART19 T Cells Manufactured Using the CliniMACS Prodigy Platform for Pediatric B-ALL (huCART19 Prodigy)

for
B Cell Acute Lymphoblastic Leukemia (B-ALL),
Location: Philadelphia PA
Sponsor: Stephan Grupp MD PhD

Sex: All

Age: 0 - 29

Code: NCT05480449

Phase1, Phase2, Recruiting

Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA With High Risk T-Cell ALL & Lymphoma

for
T-cell Acute Lymphoblastic Leukemia,
Location: Boston MA, Vallhala NY, Philadelphia PA, Gainsville FL,
Sponsor: New York Medical College

Sex: All

Age: 0 - 39

Code: NCT04972942

Phase1, Recruiting

Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype

for
Richter Syndrome, Diffuse Large B-Cell Lymphoma,
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 18+

Code: NCT06863402

Phase2, Recruiting

De-escalated Radiation for Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx

for
HPV Positive Oropharyngeal Squamous Cell Carcinoma
Location: Orange CA
Sponsor: University of California, Irvine

Sex: All

Age: 18+

Code: NCT05600842

Recruiting

Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

for
Metastatic Clear Cell Renal Cell Carcinoma,
Location: Boston MA, New Haven CT, Sherbrooke, New York NY,
Sponsor: Arcus Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT07011719

Phase3, Recruiting

A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies

for
B-cell Lymphoma, Non-Hodgkin Lymphoma, B-cell Malignancy,
Location: St Louis MO, Westwood KS, San Antonio TX,
Sponsor: CRISPR Therapeutics AG

Sex: All

Age: 18+

Code: NCT05643742

Phase1, Phase2, Recruiting

HPV DNA-Guided Radiotherapy De-intensification of Head and Neck Squamous Cell Carcinoma

for
Squamous Cell Carcinoma of the Oropharynx
Location: Richmond VA, Charlottesville VA, Miami FL
Sponsor: University of Virginia

Sex: All

Age: 18+

Code: NCT05962242

Phase2, Recruiting

Biospecimen Procurement for Head and Neck Disorders

for
Hearing Disorder, Oral Mucosal Disease, Pharyngeal Neoplasm,
Location: Baltimore MD, Washington D.C. DC, Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 3 - 70+

Code: NCT03429036

Recruiting

A Randomized Trial of Maintenance Systemic Therapy After Radiation for Oligometastatic Renal Cell Carcinoma (ASTROs)

for
Oligometastatic Renal Cell Carcinoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06004336

Phase2, Recruiting

Parametric Response Mapping (PRM) for the Detection of Chronic Lung Injury in Hematopoietic Cell Transplant Recipients

for
Chronic Lung Disease, Hematopoietic Cell Transplantation,
Location: Ann Arbor MI, Seattle WA, Stanford CA
Sponsor: University of Michigan Rogel Cancer Center

Sex: All

Age: 3+

Code: NCT05866302

Recruiting

Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion

for
Hematopoietic and Lymphoid Cell Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06184321

Early_phase1, Recruiting

Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments

for
Locally Advanced or Metastatic KRAS G12C-mutated Non-small Cell Lung Cancer,
Location: Montreal
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18 - 70+

Code: NCT07468071

Phase1, Phase2, Recruiting

Prehabilitation Program to Improve Cardiac Reserve in High-Risk Patients Undergoing Hematopoietic Stem Cell Transplantation

for
Hematopoietic Stem Cell Transplant
Location: Ann Arbor MI
Sponsor: University of Michigan Rogel Cancer Center

Sex: All

Age: 18+

Code: NCT05945121

Recruiting

Phase 1 Study Of LNK001 In Advanced Or Metastatic Clear Cell Renal Cell Carcinoma

for
Clear Cell Renal Cell Carcinoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18 - 70

Code: NCT07564232

Phase1, Recruiting

Intratumoral N17350 in Advanced Solid Tumors

for
Neoplasms, Solid Tumor, Breast Neoplasms, Triple-Negative,
Location: Buffalo NY
Sponsor: Onchilles Pharma Inc

Sex: All

Age: 18+

Code: NCT07339176

Phase1, Phase2, Recruiting