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A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

for
Epidermal Growth Factor, Epidermal Growth Factor Receptor,
Location: Lake Success NY, East Brunswick NJ, Nashville TN,
Sponsor: EpiBiologics

Sex: All

Age: 18+

Code: NCT07462377

Phase1, Recruiting

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

for
Melanoma, Non-small Cell Lung Cancer,
Location: Fairfax VA, Pittsburgh PA, Grand Rapids MI, St Louis MO,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07115043

Phase1, Phase2, Recruiting

EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer

for
Non Small Cell Lung Cancer
Location: Ann Arbor MI, Houston TX, San Diego CA
Sponsor: VA Office of Research and Development

Sex: All

Age: 18+

Code: NCT05467748

Phase1, Phase2, Recruiting

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

for
B-Cell Lymphoma, Myelodysplastic Syndromes (MDS),
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 12 - 70+

Code: NCT05092451

Phase1, Phase2, Recruiting

Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction

for
Brain Metastases, Adult, Brain Tumor - Metastatic,
Location: Boston MA
Sponsor: Ayal A. Aizer, MD

Sex: All

Age: 18+

Code: NCT07132190

Phase2, Recruiting

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Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

for
Seizures, Primary Motor Cortex,
Location: Boston MA
Sponsor: Ayal A. Aizer, MD

Sex: All

Age: 18+

Code: NCT07130786

Phase2, Recruiting

Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

for
Non-small Cell Lung Cancer
Location: Boston MA, New York NY, Fairfax VA, Orange City FL,
Sponsor: Boehringer Ingelheim

Sex: All

Age: 18+

Code: NCT07195695

Phase3, Recruiting

CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma

for
Relapsed Pediatric ALL, Hematopoietic Cell Transplantation,
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 21

Code: NCT07257419

Phase1, Recruiting

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

for
Non-small Cell Carcinoma, Non-Small Cell Lung Cancer Metastatic,
Location: Quebec, White Plains NY, The Bronx NY, Belleville NJ,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07144280

Phase3, Recruiting

A Study to Test How Well Different Doses of BI 3820768 Are Tolerated by People With Advanced Cancer (Solid Tumours)

for
Advanced Relapsed or Refractory Germ Cell Tumours,
Location: Houston TX, Los Angeles CA
Sponsor: Boehringer Ingelheim

Sex: All

Age: 18+

Code: NCT07306559

Phase1, Recruiting

Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

for
Carcinoma, Renal Cell, Advanced Renal Cell Carcinoma,
Location: Boston MA, Newton MA, Commack NY, Uniondale NY,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07227415

Phase1, Phase2, Recruiting

Study of Sacituzumab Govitecan With Atezolizumab/Durvalumab as Maintenance Therapy for Extensive-Stage Small Cell Lung Cancer

for
Small Cell Lung Cancer ( SCLC ),
Location: Detroit MI
Sponsor: Bindu R Potugari

Sex: All

Age: 18+

Code: NCT07339059

Phase2, Recruiting

Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

for
Advanced/Metastatic Non-Small Cell Lung Cancer,
Location: Neptune City NJ, The Bronx NY, Teaneck NJ,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07227298

Phase1, Phase2, Recruiting

NT-I7 (Efineptakin Alfa), a Long-acting Human IL-7, Post-Axicabtagene Ciloleucel or Post-Lisocabtagene Maraleucel in Subjects With Relapsed/Refractory Large B-cell Lymphoma

for
Large B-cell Lymphoma
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT07052305

Phase1, Recruiting

Clinical Trial to Evaluate Post-Operative Outcomes of Ureteral Stent vs Ureteral Stent Free Radical Cystectomy

for
Bladder Cancer, Muscle-Invasive Bladder Carcinoma,
Location: Philadelphia PA
Sponsor: Thomas Jefferson University

Sex: All

Age: 18 - 70+

Code: NCT07234968

Recruiting

A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)

for
Squamous Non-small Cell Lung Cancer
Location: Paramus NJ, Albany NY, Fairfax VA, Tampa FL,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07221474

Phase2, Recruiting

Tongue Proactive Strengthening Exercise Program Following Partial/Hemi Glossectomy and Reconstruction

for
Oral Cancer, Head and Neck Cancer
Location: Cleveland OH
Sponsor: Case Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT07110142

Recruiting

Interrogation of Exosome-mediated Intercellular Signaling in Patients With Pancreatic Cancer

for
Pancreatic Cancer, Benign Pancreatic Disease
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT02393703

Recruiting

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

for
Mesothelioma, Non Small Cell Lung Cancer,
Location: Brookline MA, Port Jefferson Station NY, Mineola NY,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT05245500

Phase1, Recruiting

TIL Therapy in cSCC and MCC

for
Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma,
Location: Boston MA
Sponsor: Karam Khaddour, MD, MS

Sex: All

Age: 18+

Code: NCT07288073

Phase2, Recruiting