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Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and in Patients With Other Advanced Solid Tumors

for
Advanced HR+/HER2- Breast Cancer,
Location: Boston MA, New York NY, Montreal, Toronto,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18 - 70+

Code: NCT06726148

Phase1, Phase2, Recruiting

Feasibility Trial of Glofitamab in a Response Adapted Approach Incorporating Interim FDG PET and ctDNA to Optimize Primary Therapy of DLBCL (GRAIL)

for
Diffuse Large B Cell Lymphoma (DLBCL)
Location: Montreal, Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT06050694

Phase2, Recruiting

Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

for
Mantle Cell Lymphoma
Location: Chicago IL, Providence RI, Westerly RI, Waterford CT,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 60+

Code: NCT05976763

Phase3, Recruiting

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

for
Ovarian Cancer, Breast Cancer, Endometrial Cancer,
Location: Boston MA, Philadelphia PA, Falls Church VA, Buffalo NY,
Sponsor: NextCure, Inc.

Sex: All

Age: 18+

Code: NCT06774963

Phase1, Recruiting

CT-95 in Advanced Cancers Associated With Mesothelin Expression

for
Mesothelin-Expressing Tumors, Epithelial Ovarian Cancer,
Location: Hackensack NJ, Philadelphia PA, Grand Rapids MI,
Sponsor: Context Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT06756035

Phase1, Recruiting

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Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

for
Advanced Non-Small Cell Lung Cancer,
Location: South Weymouth MA, Boston MA, Brighton MA,
Sponsor: Mirati Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT04613596

Phase2, Phase3, Recruiting

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

for
Smoldering Plasma Cell Myeloma
Location: York Village ME, Boston MA, Westerly RI, Waterford CT,
Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All

Age: 18+

Code: NCT03937635

Phase3, Recruiting

Prosthetic Performance Enhancement Trial

for
Amputation, Lower Limb Amputation Below Knee (Injury),
Location: Las Vegas NV
Sponsor: University of Nevada, Las Vegas

Sex: All

Age: 18+

Code: NCT06419920

Recruiting

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

for
Locally Advanced Lung Non-Small Cell Carcinoma,
Location: Portland ME, Scarborough ME, South Portland ME,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT05624996

Phase3, Recruiting

The Myelin Disorders Biorepository Project

for
Leukodystrophy, White Matter Disease, Leukoencephalopathies,
Location: Boston MA, Philadelphia PA, Baltimore MD,
Sponsor: Children's Hospital of Philadelphia

Sex: All

Age: 0+

Code: NCT03047369

Recruiting

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

for
Recurrent Lung Non-Small Cell Carcinoma,
Location: Brewer ME, Westerly RI, Manchester NH, Worcester MA,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT05642572

Phase2, Recruiting

Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study

for
Lung Carcinoma, Lung Non-Small Cell Carcinoma,
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT05802186

Recruiting

Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System

for
Cancer, Cancer Central Nervous System, Cancer Thoracic,
Location: New Haven CT, Pittsburgh PA, Dallas TX, Duarte CA,
Sponsor: RefleXion Medical

Sex: All

Age: 0+

Code: NCT05406167

Recruiting

Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer

for
Locally Advanced Lung Non-Small Cell Carcinoma,
Location: Columbus OH, Duarte CA
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT05136846

Phase1, Recruiting

Vaccine Responses in Patient With Multiple Myeloma and Non-Hodgkin Lymphoma After CAR-T Treatment

for
Chronic Lymphocytic Leukemia, Diffuse Large B-Cell Lymphoma,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT06784167

Recruiting

Project: Every Child for Younger Patients With Cancer

for
Adrenal Gland Pheochromocytoma, Carcinoma In Situ,
Location: St. John's, Halifax, Bangor ME, Scarborough ME,
Sponsor: Children's Oncology Group

Sex: All

Age: 0 - 25

Code: NCT02402244

Recruiting

A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

for
Small Cell Lung Cancer (SCLC),
Location: Boston MA, New Haven CT, Baltimore MD, Fairfax VA,
Sponsor: Phanes Therapeutics

Sex: All

Age: 18+

Code: NCT05652686

Phase1, Phase2, Recruiting

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

for
Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung,
Location: Fairhaven MA, Portland ME, Scarborough ME,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT06758401

Phase3, Recruiting

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for
Breast Carcinoma, Colorectal Carcinoma,
Location: Rockport ME, Belfast ME, Brunswick ME, Augusta ME,
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18+

Code: NCT06418204

Recruiting

A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs

for
Lung Cancer, Non-small Cell, Lung Cancer Metastatic,
Location: Weston FL, Canton OH, Cleveland OH, Detroit MI,
Sponsor: Krystal Biotech, Inc.

Sex: All

Age: 18+

Code: NCT06228326

Phase1, Phase2, Recruiting