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MT2023-20: Hematopoietic Cell Transplant With Reduced Intensity Conditioning and Post-transplant Cyclophosphamide for Severe Aplastic Anemia and Other Forms of Acquired Bone Marrow Failure.

for
Severe Aplastic Anemia,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 0 - 70+

Code: NCT06412497

Phase2, Recruiting

Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome

for
Severe Aplastic Anemia, Hypo-Plastic MDS,
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 4 - 70+

Code: NCT03173937

Phase1, Phase2, Recruiting

Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

for
Severe Aplastic Anemia, MDS (Myelodysplastic Syndrome)
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 4 - 70+

Code: NCT01174108

Phase2, Recruiting

TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children

for
Hemoglobinopathy (Disorder), Severe Aplastic Anemia,
Location: St. Petersburg FL
Sponsor: Johns Hopkins All Children's Hospital

Sex: All

Age: 0 - 21

Code: NCT04356469

Phase2, Recruiting

A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia

for
Recurrent Severe Aplastic Anemia,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 0 - 70+

Code: NCT05757310

Phase1, Recruiting

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Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

for
Severe Aplastic Anemia
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 3 - 70+

Code: NCT04304820

Phase2, Recruiting

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for
Hematologic Malignancies, Inherited Disorders of Metabolism,
Location: Boston MA, New Haven CT, Stony Brook NY, Lake Sucess NY,
Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All

Age: 0+

Code: NCT01351545

Recruiting

Natural History of Acquired and Inherited Bone Marrow Failure Syndromes

for
Severe Aplastic Anemia, Telomere Biology Disorders,
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 2 - 70+

Code: NCT05012111

Recruiting

Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis

for
Severe Aplastic Anemia (SAA),
Location: Bethesda MD
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All

Age: 4 - 70+

Code: NCT03520647

Phase2, Recruiting

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

for
Fanconi Anemia, Severe Aplastic Anemia,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 0 - 65

Code: NCT03579875

Phase2, Recruiting

Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for
Severe Aplastic Anemia
Location: Boston MA, New York NY, Philadelphia PA, Baltimore MD,
Sponsor: Medical College of Wisconsin

Sex: All

Age: 3 - 70+

Code: NCT06517641

Phase2, Recruiting

Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia

for
Severe Aplastic Anemia
Location: Atlanta GA
Sponsor: Northside Hospital, Inc.

Sex: All

Age: 1 - 70+

Code: NCT02828592

Phase2, Recruiting

AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

for
Acute Leukemia, Severe Aplastic Anemia, Non-hodgkin Lymphoma,
Location: Valhalla NY
Sponsor: Mitchell Cairo

Sex: All

Age: 0 - 30

Code: NCT04099966

Phase2, Recruiting

Haploidentical HCT for Severe Aplastic Anemia

for
Aplastic Anemia, Bone Marrow Failure Syndrome
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 21

Code: NCT04558736

Phase2, Recruiting

HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy

for
Fanconi Anemia, Severe Marrow Failure,
Location: Cincinnati OH, Seattle WA
Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All

Age: 0+

Code: NCT02143830

Phase2, Recruiting

Investigation of the Genetics of Hematologic Diseases

for
Bone Marrow Failure Syndromes, Erythrocyte Disorder,
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0+

Code: NCT02720679

Recruiting