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Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

for
Seizures, Primary Motor Cortex,
Location: Boston MA
Sponsor: Ayal A. Aizer, MD

Sex: All

Age: 18+

Code: NCT07130786

Phase2, Recruiting

Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction

for
Brain Metastases, Adult, Brain Tumor - Metastatic,
Location: Boston MA
Sponsor: Ayal A. Aizer, MD

Sex: All

Age: 18+

Code: NCT07132190

Phase2, Recruiting

A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3

for
Melanoma, Metastatic Melanoma, Advanced Solid Tumor,
Location: La Jolla CA
Sponsor: Replimune Inc.

Sex: All

Age: 18+

Code: NCT06887348

Recruiting

Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells

for
Solid Tumor (Excluding CNS), Liver Cell Carcinoma,
Location: Seattle WA
Sponsor: Seattle Children's Hospital

Sex: All

Age: 1 - 26

Code: NCT07148050

Phase1, Recruiting

A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

for
Advanced Solid Tumors, Ewing Sarcoma,
Location: Boston MA, New York NY, Houston TX, Duarte CA,
Sponsor: SEED Therapeutics, Inc.

Sex: All

Age: 16+

Code: NCT07197554

Phase1, Recruiting

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A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

for
Cutaneous Squamous Cell Carcinoma,
Location: Uniondale NY, New York NY, Middletown NJ, Montvale NJ,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05859074

Phase1, Recruiting

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

for
Advanced Solid Tumors, MSI-H or dMMR Advanced Solid Tumors,
Location: Houston TX
Sponsor: Eikon Therapeutics

Sex: All

Age: 18+

Code: NCT07262619

Phase1, Phase2, Recruiting

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor, Metastatic Solid Tumor,
Location: Raleigh NC, Tampa FL, Detroit MI, St Louis MO,
Sponsor: MOMA Therapeutics

Sex: All

Age: 18+

Code: NCT06974110

Phase1, Recruiting

A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors

for
Head and Neck Squamous Cell Carcinoma,
Location: Shreveport LA
Sponsor: Pure Biologics S.A.

Sex: All

Age: 18+

Code: NCT06700070

Early_phase1, Recruiting

Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

for
Solid Tumor, Advanced Cancer, Metastatic Cancer, Gastric Cancer,
Location: Boston MA, Goodyear AZ, Duarte CA
Sponsor: I-Mab Biopharma US Limited

Sex: All

Age: 18+

Code: NCT07432295

Phase2, Recruiting

CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors

for
Locally Advanced / Metastatic Solid Tumors
Location: New York NY, Washington D.C. DC, Pittsburgh PA,
Sponsor: Crescent Biopharma, Inc.

Sex: All

Age: 18+

Code: NCT07335497

Phase1, Phase2, Recruiting

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

for
Bladder Cancer, Head and Neck Squamous Cell Carcinoma,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 18+

Code: NCT03740256

Phase1, Recruiting

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor, Melanoma, Head and Neck Cancer,
Location: New Haven CT, New York NY, Baltimore MD, Buffalo NY,
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT06172478

Phase2, Recruiting

A Phase 1/1b Study of IAM1363 in HER2 Cancers

for
HER2 Mutation-Related Tumors, HER2, HER2-positive Breast Cancer,
Location: Boston MA, Lebanon NH, New York NY, New Brunswick NJ,
Sponsor: Iambic Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06253871

Phase1, Recruiting

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

for
Low-grade Glioma, Advanced Solid Tumor
Location: Boston MA, Quebec, New York NY, Montreal,
Sponsor: Day One Biopharmaceuticals, Inc.

Sex: All

Age: 0 - 25

Code: NCT04775485

Phase2, Recruiting

ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR)

for
Locally Advanced Solid Tumor, Metastatic Solid Tumor
Location: Nashville TN, Dallas TX, Denver CO, San Diego CA
Sponsor: Acepodia Biotech, Inc.

Sex: All

Age: 18+

Code: NCT06415487

Phase1, Recruiting

Safety, Pharmacokinetics, and Clinical Activity of LP-284 in Adult Patients With Relapsed or Refractory Lymphomas and Solid Tumors

for
Relapsed or Refractory Lymphomas, Advanced Solid Tumor
Location: West Valley City UT
Sponsor: Lantern Pharma Inc.

Sex: All

Age: 18+

Code: NCT06132503

Phase1, Recruiting

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

for
Solid Tumors, Advanced Cancer, Renal Cancer, Gastric Cancer,
Location: Montreal, Hershey PA, Chapel Hill NC, Toronto,
Sponsor: Apollomics Inc.

Sex: All

Age: 18+

Code: NCT03175224

Phase2, Recruiting

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

for
Early Stage Triple-Negative Breast Carcinoma,
Location: Jacksonville FL, Rochester MN, Phoenix AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06349642

Recruiting

Group Curriculum for Improving Survivorship Outcomes in Adolescent and Young Adult Cancer Survivors

for
Hematopoietic and Lymphoid System Neoplasm,
Location: Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 39

Code: NCT05584449

Recruiting