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Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

for
Advanced Solid Tumors, Metastatic Pancreatic Cancer,
Location: Bethesda MD, Fairway KS
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 12 - 70+

Code: NCT04222413

Phase1, Recruiting

A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.

for
Advanced Solid Tumors Cancer, MSI-H Cancer
Location: Providence RI, Fairfax VA, Charlottesville VA,
Sponsor: Nimbus Wadjet, Inc.

Sex: All

Age: 18 - 70+

Code: NCT06898450

Phase1, Phase2, Recruiting

A Study of HB0045 Injection in Patients With Advanced Solid Tumors

for
Solid Tumor, Adult
Location: Canton OH
Sponsor: Shanghai Huaota Biopharmaceutical Co., Ltd.

Sex: All

Age: 18+

Code: NCT06056323

Phase1, Phase2, Recruiting

To Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of DAY301 in Participants With Locally Advanced or Metastatic Solid Tumors

for
Advanced or Metastatic Solid Tumors
Location: New Haven CT, New York NY, Toronto, Sarasota FL,
Sponsor: Day One Biopharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT06752681

Phase1, Recruiting

Clinical Nurse Specialist Led Early Palliative Survivorship Care for Patients With Advanced Cancer

for
Solid Tumor, Adult, Metastasis
Location: West Islip NY
Sponsor: Good Samaritan Hospital Medical Center, New York

Sex: All

Age: 21+

Code: NCT05947695

Recruiting

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Indocyanine Green (ICG) Guided Sentinel Lymph Node Mapping for Pediatric Visceral Solid Tumors

for
Solid Tumor
Location: Pittsburgh PA, Chicago IL, Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 20

Code: NCT05645523

Early_phase1, Recruiting

A Study to Evaluate the Safety and Pharmacokinetics of Eflapegrastim in Pediatric Participants With Solid Tumors or Lymphomas and Treated With Myelosuppressive Chemotherapy

for
Solid Tumors, Lymphoma
Location: Cleveland OH
Sponsor: Spectrum Pharmaceuticals, Inc

Sex: All

Age: 0 - 17

Code: NCT04570423

Phase2, Recruiting

A Study of CUSP06 in Patients With Platinum-Refractory/Resistant Ovarian Cancer and Other Advanced Solid Tumors

for
Ovarian Cancer, Solid Tumor
Location: Boston MA, New Haven CT, New York NY, Fairfax VA,
Sponsor: OnCusp Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06234423

Phase1, Recruiting

A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib

for
Endometrioid Cancer, Mucinous Ovarian Cancer,
Location: Orlando FL, New Orleans LA, Oklahoma City OK,
Sponsor: University of Oklahoma

Sex: Female

Age: 18 - 70+

Code: NCT05512208

Phase2, Recruiting

Safety and Efficacy of p53 Gene Therapy Combined With Immune Checkpoint Inhibitors in Solid Tumors.

for
Solid Tumor, Lymphoma
Location: Morristown NJ, Chicago IL
Sponsor: MultiVir, Inc.

Sex: All

Age: 18+

Code: NCT03544723

Phase2, Recruiting

First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors

for
Solid Tumors, Sarcoma
Location: Boston MA, New York NY, Nashville TN
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT06644755

Phase1, Recruiting

JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors

for
Advanced Solid Tumor, Metastatic Solid Tumor
Location: Philadelphia PA, Fairfax VA, Durham NC, Orlando FL,
Sponsor: Jazz Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06108050

Phase1, Recruiting

Study of APR-1051 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Fairfax VA, Houston TX, Irving TX, San Antonio TX
Sponsor: Aprea Therapeutics

Sex: All

Age: 18+

Code: NCT06260514

Phase1, Recruiting

Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

for
Advanced Solid Tumor, Cutaneous Tumor, Subcutaneous Tumor,
Location: Boston MA, Bethesda MD, Toronto, Pittsburgh PA,
Sponsor: Ankyra Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06171750

Phase1, Recruiting

A Study of JNJ-87890387 for Advanced Solid Tumors

for
Neoplasms, Advanced Solid Tumors
Location: Grand Rapids MI, Nashville TN
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT06178614

Phase1, Recruiting

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Fairfax VA, Grand Rapids MI, Irving TX, Austin TX,
Sponsor: Vividion Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06804824

Phase1, Recruiting

5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors

for
Neoplasms, Solid Tumors
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT03366116

Phase1, Recruiting

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

for
Breast Cancer, Solid Tumors, Adult
Location: Boston MA, New York NY, Fairfax VA, Tampa FL,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT05768139

Phase1, Phase2, Recruiting

Personalized Models for Cancer Research

for
Solid Tumor, Adult
Location: New York NY
Sponsor: New York Stem Cell Foundation Research Institute

Sex: All

Age: 18+

Code: NCT06350539

Recruiting

A Phase 1, Multi-Center, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Minnelide™ Capsules Given Alone or in Combination With Protein-Bound Paclitaxel in Patients With Advanced Solid Tumors

for
Advanced Cancer, Gastric Cancer, Breast Cancer,
Location: Winston-Salem NC, Birmingham AL, Scottsdale AZ,
Sponsor: Minneamrita Therapeutics LLC

Sex: All

Age: 18+

Code: NCT03129139

Phase1, Recruiting