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Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

for
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC),
Location: Boston MA, New Haven CT, New York NY, Baltimore MD,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT06040541

Phase1, Recruiting

Dose-Escalation and Dose-Expansion Study of ZX-4081 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Huntersville NC
Sponsor: Nanjing Zenshine Pharmaceuticals

Sex: All

Age: 18+

Code: NCT05118841

Phase1, Recruiting

Study of Ifinatamab Deruxtecan (DS-7300a, I-DXd) in Participants With Advanced Solid Malignant Tumors

for
Advanced Solid Tumor, Malignant Solid Tumor
Location: Hackensack NJ, Sarasota FL, Denver CO
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT04145622

Phase1, Phase2, Recruiting

To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation

for
Advanced Solid Tumors
Location: Orange City FL, Lake City FL, Houston TX
Sponsor: Abion Inc

Sex: All

Age: 18+

Code: NCT05541822

Phase2, Recruiting

A Study of DB-1310 in Advanced/Metastatic Solid Tumors

for
Advanced Solid Tumor
Location: Boston MA, Fairfax VA, Plantation FL, Tamarac FL,
Sponsor: DualityBio Inc.

Sex: All

Age: 18+

Code: NCT05785741

Phase1, Phase2, Recruiting

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FIH Trial of VERT-002 in Patients With Locally Advanced or Metastatic Solid Tumors With MET Alterations

for
Solid Tumor, MET Alteration
Location: Washington D.C. DC, Canton OH, Nashville TN
Sponsor: Pierre Fabre Medicament

Sex: All

Age: 18+

Code: NCT06669117

Phase1, Phase2, Recruiting

A Study of PYX-201 in Advanced Solid Tumors

for
Solid Tumor, Advanced Solid Tumor
Location: Boston MA, Providence RI, New York NY, Philadelphia PA,
Sponsor: Pyxis Oncology, Inc

Sex: All

Age: 18+

Code: NCT05720117

Phase1, Recruiting

This is a Study to Evaluate the Safety and Tolerability of ABL503, and to Determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of ABL503 in Subjects with Any Progressive Locally Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor
Location: Denver CO, San Antonio TX, Duarte CA, LA CA,
Sponsor: ABL Bio, Inc.

Sex: All

Age: 18+

Code: NCT04762641

Phase1, Recruiting

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

for
Advanced Solid Tumors
Location: New York NY, Fairfax VA, Margate FL, Plantation FL,
Sponsor: DualityBio Inc.

Sex: All

Age: 18+

Code: NCT05914116

Phase1, Phase2, Recruiting

CGX1321 in Subjects With Advanced Solid Tumors and CGX1321 With Pembrolizumab or Encorafenib + Cetuximab in Subjects With Advanced GI Tumors (Keynote 596)

for
Solid Tumors, GI Cancer
Location: Boston MA, Baltimore MD, Washington DC, Durham NC,
Sponsor: Curegenix Inc.

Sex: All

Age: 18+

Code: NCT02675946

Phase1, Recruiting

Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Boston MA, New York NY, Philadelphia PA, Fairfax VA,
Sponsor: Pyxis Oncology, Inc

Sex: All

Age: 18+

Code: NCT06795412

Phase1, Phase2, Recruiting

Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases

for
Childhood Langerhans Cell Histiocytosis, Fanconi Anemia,
Location: Hershey PA
Sponsor: Milton S. Hershey Medical Center

Sex: All

Age: 0 - 21

Code: NCT00084695

Phase2, Recruiting

ADG126 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors

for
Advanced/Metastatic Solid Tumors
Location: Cleveland OH, Houston TX, Scottsdale AZ, Seattle WA,
Sponsor: Adagene Inc

Sex: All

Age: 18+

Code: NCT05405595

Phase1, Phase2, Recruiting

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

for
Solid Tumor, Adult, Metastatic Solid Tumor, Refractory Cancer,
Location: Fairfax VA, Canton OH, Detroit MI, St Louis MO
Sponsor: Sairopa B.V.

Sex: All

Age: 18+

Code: NCT05856981

Phase1, Recruiting

HF158K1 in Patients With HER-2 Expressing Advanced Solid Tumors

for
Solid Tumors, Adult
Location: Dallas TX
Sponsor: HighField Biopharmaceuticals Corporation

Sex: All

Age: 18 - 70+

Code: NCT05861895

Phase1, Recruiting

Molecular Analysis Of Solid Tumors

for
Pediatric Solid Tumors
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 25

Code: NCT01050296

Recruiting

An Engineered Sirpα Fused to Anti-Pd-L1 And Tgf-β Fusion Protein (HCB301) in Subjects With Selected Advanced Tumors

for
Advanced Solid Tumor, Refractory Hodgkin Lymphoma
Location: Greenville SC
Sponsor: FBD Biologics Limited

Sex: All

Age: 18+

Code: NCT06487624

Phase1, Recruiting

ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

for
Refractory Cancer, Recurrent Cancer, Solid Tumor, Adult, Cancer
Location: Boston MA, New York NY, Philadelphia PA, Miami FL,
Sponsor: Immatics US, Inc.

Sex: All

Age: 18+

Code: NCT03686124

Phase1, Phase2, Recruiting

A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer

for
Advanced Cancer, Metastatic Solid Tumor
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 1 - 25

Code: NCT05004116

Phase1, Phase2, Recruiting

A First-in-Human Study of SON-DP in Participants With Relapsed/Refractory Intolerant to Standard of Care Therapies for Advanced/Metastatic Solid Tumors

for
Solid Tumor, Breast Cancer, Pancreatic Cancer, Ovarian Cancer,
Location: Huntersville NC, Detroit MI, Houston TX,
Sponsor: Qurgen Inc.

Sex: All

Age: 18+

Code: NCT05989724

Phase1, Recruiting