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ALG.APV-527 First-in-human Study

for
Solid Tumor
Location: Port Saint Lucie FL
Sponsor: Aptevo Therapeutics

Sex: All

Age: 18+

Code: NCT05934539

Phase1, Phase2, Recruiting

A First-in-human (FIH), Phase I Study of PTX-912 in Patients with Locally Advanced/Metastatic Solid Tumors

for
Advanced Cancer, Solid Tumor, Metastatic Cancer
Location: Miami FL, Omaha NE, Duarte CA
Sponsor: Proviva Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06190886

Phase1, Recruiting

Clinical Trial of PM54 in Advanced Solid Tumors Patients.

for
Advanced Solid Tumor
Location: San Antonio TX
Sponsor: PharmaMar

Sex: All

Age: 18+

Code: NCT05841563

Phase1, Recruiting

XTX301 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: New Haven CT, Hackensack NJ, Pittsburgh PA, Canton OH,
Sponsor: Xilio Development, Inc.

Sex: All

Age: 18+

Code: NCT05684965

Phase1, Phase2, Recruiting

Study of GS-2121 Given Alone or in Combination in Adults With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Boston MA, Ottawa, Fairfax VA, Toronto, San Antonio TX,
Sponsor: Gilead Sciences

Sex: All

Age: 18+

Code: NCT06532565

Phase1, Recruiting

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CT-95 in Advanced Cancers Associated With Mesothelin Expression

for
Mesothelin-Expressing Tumors, Epithelial Ovarian Cancer,
Location: Hackensack NJ, Philadelphia PA, Grand Rapids MI,
Sponsor: Context Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT06756035

Phase1, Recruiting

A Phase 1 Study of BHV-1530 in Advanced Solid Tumors

for
Solid Tumor
Location: Fairfax VA, Myrtle Beach SC, Durham NC, Miami FL,
Sponsor: Biohaven Therapeutics Ltd.

Sex: All

Age: 18+

Code: NCT06874335

Phase1, Recruiting

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

for
Ovarian Cancer, Breast Cancer, Endometrial Cancer,
Location: Boston MA, Philadelphia PA, Falls Church VA, Buffalo NY,
Sponsor: NextCure, Inc.

Sex: All

Age: 18+

Code: NCT06774963

Phase1, Recruiting

Cisplatin, Gemcitabine, Interferon Alfa, and Hyperthermia in Treating Patients With Advanced Cancer

for
Unspecified Adult Solid Tumor, Protocol Specific
Location: Houston TX
Sponsor: The University of Texas Health Science Center, Houston

Sex: All

Age: 18+

Code: NCT00004063

Phase1, Phase2, Recruiting

Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

for
Advanced HR+/HER2- Breast Cancer,
Location: Atlanta GA, Nashville TN, San Antonio TX
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07288359

Phase1, Phase2, Recruiting

Brodalumab in the Treatment of Immune-Related Adverse Events

for
Breast Cancer, Esophageal Cancer, Kidney Cancer, Lung Cancer,
Location: New York NY
Sponsor: Brian Henick, MD

Sex: All

Age: 18+

Code: NCT06673329

Phase1, Recruiting

Evaluation of AP-002 in Patients With Solid Tumors

for
Solid Tumor
Location: Saint Louis MO, Houston TX
Sponsor: Altum Pharmaceuticals INC

Sex: All

Age: 18+

Code: NCT04143789

Phase1, Phase2, Recruiting

A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

for
Locally Advanced Solid Tumor, Metastatic Solid Tumor
Location: Boston MA, New York NY, Philadelphia PA,
Sponsor: Nuvalent Inc.

Sex: All

Age: 12+

Code: NCT05118789

Phase1, Phase2, Recruiting

PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

for
Refractory Solid Tumors, Relapsed Solid Tumors,
Location: Philadelphia PA, Houston TX, Los Angeles CA,
Sponsor: Theodore Laetsch

Sex: All

Age: 1 - 30

Code: NCT06721689

Phase1, Phase2, Recruiting

Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors

for
High-grade Glioma, Solid Tumor, Unspecified, Child
Location: Edison NJ, Miami FL, Little Rock AR
Sponsor: Laminar Pharmaceuticals

Sex: All

Age: 0 - 18

Code: NCT04299191

Phase1, Phase2, Recruiting

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: New York NY, New Brunswick NJ, Orlando FL,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT05932862

Phase1, Recruiting

Phase 1/2 Study of TU2218 Alone and in Combination With Checkpoint Inhibitors in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: San Antonio TX
Sponsor: TiumBio Co., Ltd.

Sex: All

Age: 18+

Code: NCT05204862

Phase1, Phase2, Recruiting

A Phase I Study of ROSE12 Alone and in Combination With Other Anti-tumor Agents in Patients With Solid Tumors

for
Solid Tumor
Location: Providence RI, Philadelphia PA, Fairfax VA,
Sponsor: Chugai Pharmaceutical

Sex: All

Age: 18+

Code: NCT05907980

Phase1, Recruiting

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

for
Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC),
Location: North Haven CT, Lake Success NY, Chapel Hill NC,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06413680

Phase1, Phase2, Recruiting

Dose-escalation Study of Oral CX-4945

for
Advanced Solid Tumors, Breast Cancer,
Location: Houston TX, Fort Collins CO, Loveland CO, Scottsdale AZ
Sponsor: Cylene Pharmaceuticals

Sex: All

Age: 18+

Code: NCT00891280

Phase1, Recruiting