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A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.

for
Solid Tumor, Adult, Healthy Donors, COVID-19 Donors
Location: Huntersville NC
Sponsor: BioCytics, Inc.

Sex: All

Age: 5+

Code: NCT00571389

Recruiting

Clinical Study To Further Evaluate The Efficacy Of Dabrafenib Plus Trametinib In Patients With Rare BRAF V600E Mutation-Positive Unresectable or Metastatic Solid Tumors

for
Rare Unresectable or Metastatic BRAF V600E Mutation-positive Solid Tumors,
Location: Washington D.C. DC, Durham NC, Cincinnati OH,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 1 - 70+

Code: NCT05868629

Recruiting

Study of SGR-3515 In Participants With Advanced Solid Tumors.

for
Advanced Solid Tumor
Location: New Haven CT, New York NY, Fairfax VA, Toronto,
Sponsor: Schrödinger, Inc.

Sex: All

Age: 18+

Code: NCT06463340

Phase1, Recruiting

First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.

for
Solid Tumor
Location: Orlando FL, Nashville TN, Lincoln NE, San Antonio TX
Sponsor: Corbus Pharmaceuticals Inc.

Sex: All

Age: 18+

Code: NCT06603844

Phase1, Phase2, Recruiting

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

for
Non Small Cell Lung Cancer, Glioma Glioblastoma Multiforme,
Location: Boston MA, New York NY, Washington D.C. DC, Fairfax VA,
Sponsor: Tango Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06810544

Phase1, Phase2, Recruiting

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PTT-936 Alone or in Combination in Patients With Locally Advanced or Metastatic Solid Tumors

for
Locally Advanced or Metastatic Solid Tumors
Location: Margate FL, San Antonio TX, Beverly Hills CA
Sponsor: Pyrotech Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06244992

Phase1, Phase2, Recruiting

A Beta-only IL-2 ImmunoTherapY Study

for
Advanced Solid Tumor, Unresectable Solid Tumor,
Location: Boca Raton FL, Toronto, Detroit MI, Atlanta GA,
Sponsor: Medicenna Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05086692

Phase1, Phase2, Recruiting

A Phase 1, First in Human Study of TORL-4-500 in Patients With Advanced Cancer

for
Advanced Solid Tumor, Hepatocellular Carcinoma
Location: Montreal, Lexington VA, Orlando FL, Toronto,
Sponsor: TORL Biotherapeutics, LLC

Sex: All

Age: 18+

Code: NCT06005740

Phase1, Recruiting

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

for
Solid Tumor, Adult, Triple Negative Breast Cancer,
Location: Scottsdale AZ, La Jolla CA, Stanford CA
Sponsor: BioEclipse Therapeutics

Sex: All

Age: 18+

Code: NCT04282044

Phase1, Recruiting

A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors

for
Metastatic Solid Tumor, Advanced Solid Tumor
Location: Lake Success NY, New York NY, Fairfax VA, Pittsburgh PA,
Sponsor: Coherus Oncology, Inc.

Sex: All

Age: 18+

Code: NCT06657144

Phase1, Recruiting

Trial of DFP-14927 in Advanced Solid Tumors

for
Solid Tumor, Cancer
Location: Houston TX, Los Angeles CA
Sponsor: Delta-Fly Pharma, Inc.

Sex: All

Age: 18+

Code: NCT03943004

Phase1, Recruiting

Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

for
Rectal Adenocarcinoma, Clinical Stage: Stage II (T3-4, N-),
Location: Hartford CT, Commack NY, Uniondale NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT04165772

Phase2, Recruiting

Hyperpolarized 13C MRI as a Biomarker in Advanced Solid Tumors

for
Advanced Solid Tumor
Location: San Francisco CA
Sponsor: Robert Bok, MD, PhD

Sex: All

Age: 18+

Code: NCT05599048

Phase1, Phase2, Recruiting

Registry of Older Patients With Cancer

for
Chronic Myeloproliferative Disorders,
Location: Morehead City NC, New Bern NC, Greenville NC,
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 65+

Code: NCT01137825

Recruiting

A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Providence RI, New Haven CT, Miami FL, Charleston SC,
Sponsor: Eikon Therapeutics

Sex: All

Age: 18 - 70+

Code: NCT06253130

Phase1, Phase2, Recruiting

Study of STP938 (Dencatistat) in Advanced Solid Tumours

for
Solid Tumor
Location: St. Petersburg FL, Dallas TX, San Antonio TX
Sponsor: Step Pharma, SAS

Sex: All

Age: 18+

Code: NCT06297525

Phase1, Recruiting

A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

for
Solid Tumor, Adult, Refractory Cancer,
Location: Boston MA, New Haven CT, New York NY, Fairfax VA,
Sponsor: GV20 Therapeutics

Sex: All

Age: 18+

Code: NCT05669430

Phase1, Phase2, Recruiting

ORB-021 In Patients With Advanced Solid Tumors

for
Advanced Solid Tumors Cancer
Location: Houston TX, Scottsdale AZ
Sponsor: Orionis Biosciences Inc

Sex: All

Age: 18+

Code: NCT06607939

Phase1, Recruiting

Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

for
Advanced or Metastatic Solid Tumor, Liver Failure
Location: Newark DE, Baltimore MD, Houston TX, San Antonio TX
Sponsor: Gilead Sciences

Sex: All

Age: 18+

Code: NCT04617522

Phase1, Recruiting

Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

for
NSCLC, HNSCC, Melanoma, Metastatic Cancer, Advanced Solid Tumor,
Location: Pittsburgh PA, Irvine CA
Sponsor: CJ Bioscience, Inc.

Sex: All

Age: 18+

Code: NCT05877430

Phase1, Phase2, Recruiting