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A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors

for
Advanced NRAS-Mutant Melanoma,
Location: Boston MA, New York NY, Fairfax VA, Grand Rapids MI,
Sponsor: Relay Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07584226

Phase1, Recruiting

A Phase Ⅰ/Ⅱa Study of HMPL-A251 in Participants With Advanced or Metastatic HER2-expressing Solid Tumors

for
Solid Tumors, Adult
Location: Plantation FL, Cleveland OH, Denver CO
Sponsor: Hutchmed

Sex: All

Age: 18+

Code: NCT07228247

Phase1, Phase2, Recruiting

A First-in-Human Study of BG-C0979 in Adults With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Hackensack NJ, St Louis MO, San Antonio TX
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT07414836

Phase1, Recruiting

A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

for
KRAS-mutant Non-small Cell Lung Cancer (NSCLC),
Location: Boston MA, Philadelphia PA, Fairfax VA, Tampa FL,
Sponsor: Kestrel Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07458347

Phase1, Recruiting

Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs.

for
GEP-NET, Gastroenteropancreatic Neuroendocrine Tumor,
Location: Montreal, Charlottesville VA, Toronto, Jacksonville FL,
Sponsor: RayzeBio, Inc.

Sex: All

Age: 18+

Code: NCT07165132

Phase1, Recruiting

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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for
Solid Tumors
Location: Boston MA, Lake Success NY, The Bronx NY, New York NY,
Sponsor: Incyte Corporation

Sex: All

Age: 18+

Code: NCT07522073

Phase3, Recruiting

A Trial to Investigate the Safety of E303 in Participants With Advanced Refractory Solid Tumors

for
Advanced Solid Tumors
Location: Fairfax VA, Scottsdale AZ
Sponsor: Samsung Bioepis Co., Ltd.

Sex: All

Age: 18+

Code: NCT07524348

Phase1, Recruiting

Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors

for
Solid Tumor, Small Cell Lung Cancer (SCLC),
Location: Fort Worth TX, West Valley City UT, Los Angeles CA
Sponsor: Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT07517198

Phase1, Recruiting

NCI Childhood Cancer Data Initiative (CCDI) Led Pediatric, Adolescent, and Young Adult Rare Cancer Registry for Very Rare Solid Tumors

for
Very Rare Tumors, Very Rare Cancers, Other Solid Tumors,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 0 - 70+

Code: NCT07489378

Recruiting

Trial Investigating Visugromab and Nivolumab With or Without Docetaxel in 2L Treatment of Participants With Metastatic NSCLC

for
Metastatic Non-Squamous Non-Small Cell Lung Cancer,
Location: Mineola NY, New York NY, Durham NC, Birmingham AL,
Sponsor: CatalYm GmbH

Sex: All

Age: 18+

Code: NCT07246863

Phase2, Recruiting

Lattice Radiation Therapy Versus Conventional Radiation Therapy for the Palliation of Large Tumors

for
Histopathologically or Cytologically Confirmed Solid Tumor Who Require Palliation Radiation Therapy to a Lesion ≥5cm,
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18 - 70+

Code: NCT07444775

Phase3, Recruiting

Trial Investigating Visugromab in Combination With Immunochemotherapy in 1L Treatment of Participants With Metastatic NSCLC

for
Metastatic Non-Squamous Non-Small Cell Lung Cancer,
Location: New Haven CT, New York NY, Durham NC, Charleston SC,
Sponsor: CatalYm GmbH

Sex: All

Age: 18+

Code: NCT07098988

Phase2, Recruiting

AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors

for
Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR),
Location: Westbrook ME, Toronto, Indianapolis IN, Nashville TN,
Sponsor: Amgen

Sex: All

Age: 18 - 70+

Code: NCT07403721

Phase1, Recruiting

Study in Advanced Solid Tumor Patients

for
Advanced Solid Tumor
Location: Nashville TN, Houston TX, San Antonio TX,
Sponsor: Callio Therapeutics

Sex: All

Age: 18+

Code: NCT07300943

Phase1, Phase2, Recruiting

Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot Study

for
Solid Tumor Malignancies, Brain Metastasases,
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18+

Code: NCT07476781

Recruiting

A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.

for
TP53 Y220C Mutation, Advanced Solid Tumors
Location: Orlando FL, Nashville TN, Dallas TX, San Antonio TX,
Sponsor: PMV Pharmaceuticals, Inc

Sex: All

Age: 18+

Code: NCT07372625

Phase1, Recruiting

SB-4826 in Adult Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin Lymphomas

for
Non Hodgkin Lymphoma, Solid Tumor
Location: La Jolla CA
Sponsor: University of California, San Diego

Sex: All

Age: 18+

Code: NCT07222631

Phase1, Phase2, Recruiting

A Study of GEN1106 in Participants With Solid Tumors

for
Solid Tumors, Urothelial Carcinoma
Location: New Haven CT, Lake Success NY, Myrtle Beach SC,
Sponsor: Genmab

Sex: All

Age: 18+

Code: NCT07416123

Phase1, Recruiting

Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors

for
Solid Tumors, Sarcomas
Location: New Haven CT, New York NY, Fairfax VA, Sarasota FL,
Sponsor: Zai Lab (Shanghai) Co., Ltd.

Sex: All

Age: 18+

Code: NCT07374848

Phase1, Recruiting

A First in Human Study of PLT012 in Participants With Solid Tumor Cancers

for
Advanced Malignant Solid Tumor, Solid Tumor Cancer
Location: Houston TX, Dallas TX, Los Angeles CA
Sponsor: Pilatus Biosciences Inc

Sex: All

Age: 18+

Code: NCT07337525

Phase1, Recruiting