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STM-06: POLARIS-POlymetastic Lesion Ablative Radiotherapy With Immunotherapy Study

for
Advanced Solid Tumor, Metastatic Cancer
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 18+

Code: NCT07269080

Phase1, Recruiting

A Clinical Study of YL205 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: New Haven CT, Lake Mary FL, Louisville KY, Denver CO,
Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT06459973

Phase1, Phase2, Recruiting

A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

for
Colorectal Cancer, Pancreatic Cancer,
Location: Boston MA, Fairfax VA, San Antonio TX,
Sponsor: PAQ Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07300150

Phase1, Recruiting

Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells

for
Solid Tumor (Excluding CNS), Liver Cell Carcinoma,
Location: Seattle WA
Sponsor: Seattle Children's Hospital

Sex: All

Age: 1 - 26

Code: NCT07148050

Phase1, Recruiting

A Study of PARG Inhibitor FORX-428 in Patients With Advanced Solid Tumors.

for
Advanced Solid Tumors
Location: Fairfax VA, Grand Rapids MI, St Louis MO, Houston TX,
Sponsor: FoRx Therapeutics AG

Sex: All

Age: 18+

Code: NCT07356453

Phase1, Recruiting

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Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

for
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC),
Location: Boston MA, New Haven CT, New York NY, Baltimore MD,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT07349537

Phase1, Recruiting

Trial to Evaluate irAEs With Different Standard of Care Dosing Strategies of Standard of Care Immunotherapies

for
Solid Tumor Malignancies
Location: Westwood KS
Sponsor: University of Kansas Medical Center

Sex: All

Age: 18+

Code: NCT07174453

Phase3, Recruiting

An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors

for
Breast Cancer, Advanced Solid Tumor
Location: New Haven CT, Birmingham AL, St Louis MO, Houston TX,
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT07222267

Phase1, Recruiting

A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

for
Advanced Solid Tumors, Ewing Sarcoma,
Location: Boston MA, New York NY, Houston TX, Duarte CA,
Sponsor: SEED Therapeutics, Inc.

Sex: All

Age: 16+

Code: NCT07197554

Phase1, Recruiting

A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants With Advanced Solid Tumors Previously Treated With Standard of Care Therapy

for
Advanced Solid Tumors
Location: Fairfax VA, Huntersville NC, San Antonio TX
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07161414

Phase1, Recruiting

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

for
Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma,
Location: Boston MA, New York NY, Fairfax VA, Durham NC,
Sponsor: Plexium, Inc.

Sex: All

Age: 18+

Code: NCT07284186

Phase1, Recruiting

JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration

for
Advanced Solid Tumors
Location: Cleveland OH, St Louis MO, Rochester MN,
Sponsor: Jacobio Pharmaceuticals Co., Ltd.

Sex: All

Age: 18+

Code: NCT06973564

Phase1, Phase2, Recruiting

A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

for
Cutaneous Squamous Cell Carcinoma,
Location: Uniondale NY, New York NY, Middletown NJ, Montvale NJ,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT05859074

Phase1, Recruiting

xDRIVE for Florida-based Cancer Patients

for
Cancer, Neoplams, Refractory, Recurrence, Leukaemia, Lymphoma,
Location: Miami FL
Sponsor: First Ascent Biomedical Inc.

Sex: All

Age: 0+

Code: NCT07167381

Recruiting

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

for
Recurrent Solid Tumor, Recurrent Ewing Sarcoma,
Location: Montreal, Washington D.C. DC, Toronto, Atlanta GA,
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 1 - 30

Code: NCT04901702

Phase1, Phase2, Recruiting

Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies

for
Advanced Solid Tumor
Location: Port Huron MI, Macomb MI, Detroit MI, Lapeer MI,
Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All

Age: 18+

Code: NCT07098299

Phase1, Recruiting

Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

for
Childhood Cancer, Childhood Solid Tumor, Childhood Brain Tumor,
Location: Montreal, Toronto, Vancouver
Sponsor: Australian & New Zealand Children's Haematology/Oncology Group

Sex: All

Age: 0 - 21

Code: NCT06208657

Phase1, Phase2, Recruiting

Dose Escalation and Expansion Study of HM16390 Alone or With Pembrolizumab in Advanced or Metastatic Solid Tumors

for
Advanced or Metastatic Solid Tumors
Location: Boston MA
Sponsor: Hanmi Pharmaceutical Company Limited

Sex: All

Age: 18+

Code: NCT06724016

Phase1, Recruiting

Evaluate the Safety, Tolerability, and Preliminary Efficacy of EVM14 Alone and in Combination in Patients With Selected Solid Tumors

for
Selected Types of Solid Tumor
Location: New York NY, Fairfax VA, Houston TX
Sponsor: Everest Medicines (Beijing) Co., Ltd.

Sex: All

Age: 18+

Code: NCT07095868

Phase1, Phase2, Recruiting

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

for
Solid Tumor, Adult, Non-small Cell Lung Cancer, Melanoma
Location: New York NY, New Brunswick NJ, Morristown NJ,
Sponsor: Pierre Fabre Medicament

Sex: All

Age: 18+

Code: NCT04913285

Phase1, Recruiting