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Tumor Immunotherapy and Microbiome Analysis

for
Advanced Solid Tumor
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18+

Code: NCT04579978

Recruiting

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

for
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC),
Location: Boston MA, New York NY, Baltimore MD, Fairfax VA,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT05379985

Phase1, Phase2, Recruiting

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

for
Bladder Cancer, Head and Neck Squamous Cell Carcinoma,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 18+

Code: NCT03740256

Phase1, Recruiting

A Study of RX108 in Patients With Locally Advanced or Metastatic Solid Tumors

for
Locally Advanced Solid Tumors, Metastatic Solid Tumors
Location: Houston TX, Los Angeles CA
Sponsor: NeuPharma, Inc.

Sex: All

Age: 18+

Code: NCT03646071

Phase1, Recruiting

Collection and Storage of Tissue Samples From Patients Undergoing Surgery For Suspected Solid Tumors

for
Unspecified Adult Solid Tumor, Protocol Specific,
Location: Winston-Salem NC
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18 - 70+

Code: NCT00900471

Recruiting

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A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor, Melanoma, Head and Neck Cancer,
Location: New Haven CT, New York NY, Baltimore MD, Buffalo NY,
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT06172478

Phase2, Recruiting

First In Human Study of CX-2051 in Advanced Solid Tumors

for
Solid Tumor, Adult
Location: Boston MA, The Bronx NY, Fairfax VA, Huntersville NC,
Sponsor: CytomX Therapeutics

Sex: All

Age: 18+

Code: NCT06265688

Phase1, Recruiting

An Extension Study for Patients Previously Enrolled in Studies With Pelabresib

for
Hematologic Malignancy, Solid Tumor, Advanced Malignancies
Location: New York NY, Jacksonville FL, Ann Arbor MI, Chicago IL,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06401356

Phase3, Recruiting

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Boston MA, Toronto, Ann Arbor MI, Houston TX, Dallas TX,
Sponsor: LigaChem Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT05941507

Phase1, Phase2, Recruiting

Open-Label, Dose-Escalation With Expansion to Assess the Safety, Tolerability, and PK of TRE-515 in Subjects With Solid Tumors

for
Solid Tumor, Adult, Oncology
Location: Huntersville NC, Santa Monica CA
Sponsor: Trethera

Sex: All

Age: 18+

Code: NCT05055609

Phase1, Recruiting

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

for
Advanced Solid Tumor, High Grade Serous Adenocarcinoma of Ovary,
Location: Providence RI, New Haven CT, New York NY, Baltimore MD,
Sponsor: Volastra Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05902988

Phase1, Phase2, Recruiting

A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types

for
Solid Tumor
Location: New York NY, Tampa FL, Augusta GA, Chicago IL,
Sponsor: Eisai Inc.

Sex: All

Age: 18+

Code: NCT04300556

Phase1, Phase2, Recruiting

Study of Lunresertib Alone or in Combination With RP-3500 or Debio 0123 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Boston MA, Providence RI, New Haven CT,
Sponsor: Debiopharm International SA

Sex: All

Age: 12+

Code: NCT04855656

Phase1, Recruiting

A Phase 1/1b Study of IAM1363 in HER2 Cancers

for
HER2 Mutation-Related Tumors, HER2, HER2-positive Breast Cancer,
Location: Boston MA, Lebanon NH, New York NY, New Brunswick NJ,
Sponsor: Iambic Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06253871

Phase1, Recruiting

A Phase 1/2 Study of KSQ-004EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate Genes Encoding SOCS1 and Regnase-1, in Patients With Select Advanced Solid Tumors

for
Select Advanced Solid Tumors
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06598371

Phase1, Phase2, Recruiting

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for
Advanced Solid Tumors With KRAS G12C Mutations,
Location: Boston MA, Philadelphia PA, Fairfax VA, Detroit MI,
Sponsor: Frontier Medicines Corporation

Sex: All

Age: 18+

Code: NCT06244771

Phase1, Phase2, Recruiting

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

for
Metastatic Uveal Melanoma, Cutaneous Melanoma,
Location: Philadelphia PA, Durham NC, Cincinnati OH, Nashville TN,
Sponsor: IDEAYA Biosciences

Sex: All

Age: 18+

Code: NCT03947385

Phase1, Phase2, Recruiting

Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: North Haven CT, Ottawa, Toronto, Orlando FL,
Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT06384352

Phase1, Recruiting

Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

for
Solid Tumors
Location: Boston MA, New Haven CT, New York NY, Philadelphia PA,
Sponsor: ORIC Pharmaceuticals

Sex: All

Age: 18+

Code: NCT05315700

Phase1, Phase2, Recruiting

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

for
Low-grade Glioma, Advanced Solid Tumor
Location: Boston MA, Quebec, New York NY, Montreal,
Sponsor: Day One Biopharmaceuticals, Inc.

Sex: All

Age: 0 - 25

Code: NCT04775485

Phase2, Recruiting